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== Function == | == Function == | ||
'''Bleomycin''' is a DNA cutting agent that is produced by actinomycetes. To protect themselves, these organisms have to sequester this lethal compound, which is achieved by a specific Bleomycin-binding protein (BBP) or Bleomycin-resistance protein (BRP). | '''Bleomycin''' is a DNA cutting agent that is produced by actinomycetes. To protect themselves, these organisms have to sequester this lethal compound, which is achieved by a specific Bleomycin-binding protein (BBP) or Bleomycin-resistance protein (BRP). | ||
| - | The crystal structure of a BBP from ''Streptoalloteoichus hindustanus'' has been solved <ref>7516875</ref> | + | The crystal structure of a BBP from ''Streptoalloteoichus hindustanus'' has been solved <ref>PMID 7516875</ref> |
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 13:51, 31 January 2019
Structure of bleomycin protein
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Dumas P, Bergdoll M, Cagnon C, Masson JM. Crystal structure and site-directed mutagenesis of a bleomycin resistance protein and their significance for drug sequestering. EMBO J. 1994 Jun 1;13(11):2483-92. PMID:7516875
