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<StructureSection load='1BYL' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1BYL' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10. | + | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1074/jbc.M009874200</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. |
== Function == | == Function == | ||
'''Bleomycin''' is a DNA cutting agent that is produced by actinomycetes. To protect themselves, these organisms have to sequester this lethal compound, which is achieved by a specific Bleomycin-binding protein (BBP) or Bleomycin-resistance protein (BRP). | '''Bleomycin''' is a DNA cutting agent that is produced by actinomycetes. To protect themselves, these organisms have to sequester this lethal compound, which is achieved by a specific Bleomycin-binding protein (BBP) or Bleomycin-resistance protein (BRP). | ||
| - | The crystal structure of a BBP from ''Streptoalloteoichus hindustanus'' has been solved <ref> | + | The crystal structure of a BBP from ''Streptoalloteoichus hindustanus'' has been solved <ref>PMID 7516875</ref>. |
| + | Another structure was solved in <scene name='80/807426/Bbp_bleomycin/1'>complex with the bleomycin</scene> <ref>DOI 10.1074/jbc.M009874200</ref> . | ||
| + | A morphing from one structure to the other one is <scene name='80/807426/Morphing/2'>shown here</scene> | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
Structure of bleomycin protein
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References
- ↑ Maruyama M, Kumagai T, Matoba Y, Hayashida M, Fujii T, Hata Y, Sugiyama M. Crystal structures of the transposon Tn5-carried bleomycin resistance determinant uncomplexed and complexed with bleomycin. J Biol Chem. 2001 Mar 30;276(13):9992-9. Epub 2000 Dec 29. PMID:11134052 doi:10.1074/jbc.M009874200
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Dumas P, Bergdoll M, Cagnon C, Masson JM. Crystal structure and site-directed mutagenesis of a bleomycin resistance protein and their significance for drug sequestering. EMBO J. 1994 Jun 1;13(11):2483-92. PMID:7516875
- ↑ Maruyama M, Kumagai T, Matoba Y, Hayashida M, Fujii T, Hata Y, Sugiyama M. Crystal structures of the transposon Tn5-carried bleomycin resistance determinant uncomplexed and complexed with bleomycin. J Biol Chem. 2001 Mar 30;276(13):9992-9. Epub 2000 Dec 29. PMID:11134052 doi:10.1074/jbc.M009874200
