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1lbd

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[[Image:1lbd.gif|left|200px]]<br /><applet load="1lbd" size="350" color="white" frame="true" align="right" spinBox="true"
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#REDIRECT [[6hn6]] This PDB entry is obsolete and replaced by 6hn6
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caption="1lbd, resolution 2.7&Aring;" />
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'''LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA'''<br />
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==Overview==
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The crystal structure of the human retinoid-X receptor RXR-alpha ligand-binding domain reveals a previously undiscovered fold of an antiparallel alpha-helical sandwich, packed as dimeric units. Two helices and one loop form the homodimerization surface, and hydrophobic heptad repeats participate in stabilizing the fold. The existence of a ligand-binding pocket is proposed that would allow 9-cis retinoic acid to interact with different functional modules, including the AF-2 activating domain. Several lines of evidence indicate that the overall structure is a prototype fold of ligand-binding domains of nuclear receptors.
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==About this Structure==
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1LBD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBD OCA].
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==Reference==
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Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha., Bourguet W, Ruff M, Chambon P, Gronemeyer H, Moras D, Nature. 1995 Jun 1;375(6530):377-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7760929 7760929]
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[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Bourguet, W.]]
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[[Category: Moras, D.]]
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[[Category: SPINE, Structural Proteomics in Europe.]]
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[[Category: nuclear receptor]]
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[[Category: spine]]
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[[Category: structural genomics]]
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[[Category: structural proteomics in europe]]
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[[Category: transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:43:25 2008''
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Current revision

  1. REDIRECT 6hn6 This PDB entry is obsolete and replaced by 6hn6

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