This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


6gls

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "6gls" [edit=sysop:move=sysop])
Current revision (06:43, 21 February 2019) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6gls is ON HOLD
+
==Crystal structure of hMTH1 N33G in complex with TH scaffold 1 in the absence of acetate==
-
 
+
<StructureSection load='6gls' size='340' side='right' caption='[[6gls]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-
Authors: Eberle, S.A., Wiedmer, L., Sledz, P., Caflisch, A.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6gls]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GLS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GLS FirstGlance]. <br>
-
Description: hMTH1 N33G in complex with TH scaffold 1.
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F3E:4-phenylpyrimidin-2-amine'>F3E</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gls OCA], [http://pdbe.org/6gls PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gls RCSB], [http://www.ebi.ac.uk/pdbsum/6gls PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gls ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Caflisch, A]]
[[Category: Caflisch, A]]
 +
[[Category: Eberle, S A]]
 +
[[Category: Sledz, P]]
[[Category: Wiedmer, L]]
[[Category: Wiedmer, L]]
-
[[Category: Sledz, P]]
+
[[Category: Complex]]
-
[[Category: Eberle, S.A]]
+
[[Category: Dna repair]]
 +
[[Category: Fragment]]
 +
[[Category: Hydrolase]]
 +
[[Category: Inhibitor]]

Current revision

Crystal structure of hMTH1 N33G in complex with TH scaffold 1 in the absence of acetate

6gls, resolution 1.50Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6gls"
Personal tools