6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase

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</StructureSection>
</StructureSection>
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==3D structures of HPPK==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*HPPK
 
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**[[1hka]], [[1eq0]] – EcHPPK – ''Escherichia coli''<br />
 
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**[[1g4c]], [[1im6]], [[1kbr]], [[1rtz]], [[1tmj]], [[3hcx]], [[3hsd]], [[3hsj]], [[3hsz]], [[3ili]], [[3ill]], [[3kue]], [[3kug]] – EcHPPK (mutant) <br />
 
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**[[2f63]], [[2f65]] – EcHPPK - NMR <br />
 
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*HPPK binary complex
 
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**[[1cbk]] – HPPK + dihydro-dimethyl-6-hydroxypterin – ''Haemophilus influenza''<br />
 
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**[[1eqm]] – EcHPPK + ADP <br />
 
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**[[1ex8]] – EcHPPK + adenosine-tetraphosphate-methyl-dihydropterin <br />
 
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**[[1rb0]] – EcHPPK + 6-hydroxymethylpterin-diphosphate <br />
 
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**[[3hd1]], [[3hsg]], [[3ht0]], [[3ilj]], [[3kuh]] – EcHPPK (mutant) + methyleneadenosine-triphosphate <br />
 
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**[[3ud5]], [[3ude]], [[3udv]], [[4f7v]] – EcHPPK + inhibitor <br />
 
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**[[4pzv]] - HPPK/DHPS + inhibitor - ''Francisella tularensis''<br />
 
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**[[3qbc]] – SaHPPK + inhibitor – ''Staphylococcus aureus''<br />
 
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*HPPK ternary complex
 
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**[[1ru2]], [[1tmm]] – EcHPPK (mutant) + methyleneadenosine-triphosphate + 6-hydroxymethylpterin <br />
 
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**[[1dy3]] – EcHPPK (mutant) + ATP + pteridine derivative <br />
 
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**[[3ip0]] – EcHPPK + methyleneadenosine-triphosphate + pteridine derivative <br />
 
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**[[1f9h]], [[1hq2]], [[1q0n]], [[1ru1]], [[3ilo]] – EcHPPK (mutant) + methyleneadenosine-triphosphate + pteridine derivative <br />
 
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**[[3hd2]] – EcHPPK (mutant) + methyleneadenosine-triphosphate + pterine <br />
 
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**[[4m5g]], [[4m5h]], [[4m5i]], [[4m5j]], [[4m5k]], [[4m5l]], [[4m5m]], [[4m5n]] – EcHPPK + methyleneadenosine-triphosphate + inhibitor <br />
 
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**[[1rao]] – EcHPPK (mutant) + AMP + 6-hydroxymethylpterin-diphosphate <br />
 
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**[[5etl]], [[5etm]], [[5etn]], [[5eto]], [[5etp]], [[5etq]], [[5etr]], [[5ets]], [[5ett]], [[5etv]] - EcHPPK + AMPCPP + inhibitor<br />
 
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**[[4crj]], [[4cwb]], [[4cyu]] - SaHPPK + AMPCPP + inhibitor<br />
 
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**[[2qx0]] – HPPK + methyleneadenosine-triphosphate + pteridine derivative – ''Yersinia pestis''<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:08, 21 February 2019

Structure of E. coli HPPK complex with inhibitor (green) (PDB code 3udv).

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References

  1. ↑ Xiao B, Shi G, Chen X, Yan H, Ji X. Crystal structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, a potential target for the development of novel antimicrobial agents. Structure. 1999 May;7(5):489-96. PMID:10378268

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