7,8-dihydro-8-oxoguanine triphosphatase

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*<scene name='59/597008/Cv/5'>Active site</scene> of DGTP (PDB code [[3zr0]]).<ref>PMID:21787772</ref> Water molecules are shown as red spheres.
*<scene name='59/597008/Cv/5'>Active site</scene> of DGTP (PDB code [[3zr0]]).<ref>PMID:21787772</ref> Water molecules are shown as red spheres.
*<scene name='59/597008/Cv/6'>8-oxo-dGTP is located in the tunnel</scene>.
*<scene name='59/597008/Cv/6'>8-oxo-dGTP is located in the tunnel</scene>.
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==3D structures of 7,8-dihydro-8-oxoguanine triphosphatase==
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[[7,8-dihydro-8-oxoguanine triphosphatase 3D structures]]
</StructureSection>
</StructureSection>

Revision as of 09:39, 24 February 2019

Structure of human MTH1 complex with 8-oxo-dGTP and sulfate (PDB code 3zr0).

Drag the structure with the mouse to rotate

3D structures of 7,8-dihydro-8-oxoguanine triphosphatase

Updated on 24-February-2019

References

  1. Nakamura T, Meshitsuka S, Kitagawa S, Abe N, Yamada J, Ishino T, Nakano H, Tsuzuki T, Doi T, Kobayashi Y, Fujii S, Sekiguchi M, Yamagata Y. Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base. J Biol Chem. 2010 Jan 1;285(1):444-52. Epub 2009 Oct 28. PMID:19864691 doi:10.1074/jbc.M109.066373
  2. Svensson LM, Jemth AS, Desroses M, Loseva O, Helleday T, Hogbom M, Stenmark P. Crystal structure of human MTH1 and the 8-oxo-dGMP product complex. FEBS Lett. 2011 Aug 19;585(16):2617-21. Epub 2011 Jul 23. PMID:21787772 doi:10.1016/j.febslet.2011.07.017

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