A Disintegrin And Metalloproteinase
From Proteopedia
(Difference between revisions)
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ADAM inhibitors are used in anti-cancer therapy. ADAM33 is implicated in asthma. ADAMTS13 cleaves von Willebrand factor involved in blood clotting. | ADAM inhibitors are used in anti-cancer therapy. ADAM33 is implicated in asthma. ADAMTS13 cleaves von Willebrand factor involved in blood clotting. | ||
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| + | == 3D Structures of A Disintegrin And Metalloproteinase == | ||
| + | [[A Disintegrin And Metalloproteinase 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
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**[[6bdz]] – hADAM10 + antibody<br /> | **[[6bdz]] – hADAM10 + antibody<br /> | ||
| - | *ADAM17 | + | *ADAM17 or TACE or TNF-alpha converting enzyme |
**[[2m2f]] – hADAM17 membrane-proximal domain - NMR<br /> | **[[2m2f]] – hADAM17 membrane-proximal domain - NMR<br /> | ||
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*ADAM22 | *ADAM22 | ||
| - | **[[3g5c]] | + | **[[3g5c]] - hADAM22 ectodomain<br /> |
| + | **[[5y31]], [[5y2z]] – hADAM22 ectodomain + LGI1<br /> | ||
*ADAM33 | *ADAM33 | ||
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**[[2rjq]] - hADAMTS5 residues 262-628 + inhibitor<br /> | **[[2rjq]] - hADAMTS5 residues 262-628 + inhibitor<br /> | ||
| - | **[[3b8z]], [[3hy7]], [[3hy9]], [[ | + | **[[3b8z]], [[3hy7]], [[3hy9]], [[3hyg]], [[3ljt]] - hADAMTS5 catalytic domain (mutant) + inhibitor |
*ADAMTS13 | *ADAMTS13 | ||
Revision as of 10:23, 24 February 2019
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3D Structures of A Disintegrin And Metalloproteinase
Updated on 24-February-2019
References
- ↑ Edwards DR, Handsley MM, Pennington CJ. The ADAM metalloproteinases. Mol Aspects Med. 2008 Oct;29(5):258-89. doi: 10.1016/j.mam.2008.08.001. Epub 2008, Aug 15. PMID:18762209 doi:http://dx.doi.org/10.1016/j.mam.2008.08.001
