Acetyl-CoA synthetase
From Proteopedia
(Difference between revisions)
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | <StructureSection load='' size='350' side='right' scene='49/492048/Cv/ | + | <StructureSection load='' size='350' side='right' scene='49/492048/Cv/9' caption='Acetyl-CoA synthetase complex with CoA and AMP (PDB code [[2p2j]])'> |
__TOC__ | __TOC__ | ||
| Line 11: | Line 11: | ||
== Structural Highlights == | == Structural Highlights == | ||
| - | *<scene name='49/492048/Cv/ | + | *<scene name='49/492048/Cv/10'>CoA binding site</scene>. Water molecules shown as red spheres. |
| - | *<scene name='49/492048/Cv/ | + | *<scene name='49/492048/Cv/7'>AMP binding site</scene>. |
| - | *<scene name='49/492048/Cv/ | + | *<scene name='49/492048/Cv/8'>CoA/AMP binding site</scene> ([[2p2j]]).<ref>PMID:17497934</ref> |
| - | + | ||
==3D structures of acetyl-CoA synthetase== | ==3D structures of acetyl-CoA synthetase== | ||
| + | [[Acetyl-CoA synthetase 3D structures]] | ||
| - | + | </StructureSection> | |
| - | + | ||
| - | [[1pg3]], [[1pg4]] – SeACS (mutant) + CoA + AMP – ''Salmonella enterica''<br /> | ||
| - | [[2p20]], [[2p2m]], [[2p2q]] - StACS (mutant) + AMP – ''Salmonella typhimurium''<br /> | ||
| - | [[2p2b]], [[2p2j]] - StACS (mutant) + CoA + AMP<br /> | ||
| - | [[2p2f]], [[5jrh]] - StACS + CoA + AMP<br /> | ||
| - | [[1ry2]] – ACS + AMP - yeast<br /> | ||
| - | [[4u5y]] – ACS GNAT domain + SeACS C terminal (mutant) – ''Streptomyces lividans''<br /> | ||
| - | [[5k85]] - CnACS + APP + CoA - ''Cryptococcus neoformans''<br /> | ||
| - | [[5k8f]] - CnACS + ATP + acetyl-AMP <br /> | ||
| - | [[5ifi]] - CnACS + APP <br /> | ||
| - | [[4xyl]], [[5hbr]] - KcACS + CoA - ''Korarchaeum cryptofilum''<br /> | ||
| - | [[4xym]] - KcACS + AMPCP + CoA <br /> | ||
| - | [[4xz3]] - KcACS + AMPPCP + CoA <br /> | ||
| - | [[4y8v]], [[4yb8]], [[4ybz]] - KcACS + ADP <br /> | ||
| - | [[4yaj]] - KcACS <br /> | ||
| - | [[4yak]] - KcACS + CoA + acetyl-CoA <br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
References
- ↑ Jogl G, Tong L. Crystal structure of yeast acetyl-coenzyme A synthetase in complex with AMP. Biochemistry. 2004 Feb 17;43(6):1425-31. PMID:14769018 doi:10.1021/bi035911a
- ↑ Reger AS, Carney JM, Gulick AM. Biochemical and crystallographic analysis of substrate binding and conformational changes in acetyl-CoA synthetase. Biochemistry. 2007 Jun 5;46(22):6536-46. Epub 2007 May 12. PMID:17497934 doi:http://dx.doi.org/10.1021/bi6026506
