DNA adenine methylase

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<StructureSection load='1q0s' size='340' side='right' caption='Phage T4 DNA adenine metylase complex with SAH, DNA and I- ion (PDB code [[1q0t]])' scene=''>
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<StructureSection load='' size='350' side='right' caption='Phage T4 DNA adenine metylase complex with SAH, DNA and I- ion (purple) (PDB code [[1q0t]])' scene='51/517445/Cv/1'>
== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==
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DAM uses S-adenosyl-L-homocysteine (AdoHcy, SAH) as methyl donor.<ref>PMID:12937411</ref>
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DAM uses S-adenosyl-L-homocysteine (AdoHcy, SAH) as methyl donor.
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<scene name='51/517445/Cv/10'>Phage T4 DNA adenine metylase with SAH, DNA and I- ions</scene>
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<scene name='51/517445/Cv/11'>SAH binding site</scene>
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<scene name='51/517445/Cv/12'>DNA binding site</scene>
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<scene name='51/517445/Cv/13'>Iod coordination site</scene> (PDB code [[1q0t]]) <ref>PMID:12937411</ref>
</StructureSection>
</StructureSection>
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== References ==
== References ==
<references/>
<references/>
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[[Category:Topic Page]]

Current revision

Phage T4 DNA adenine metylase complex with SAH, DNA and I- ion (purple) (PDB code 1q0t)

Drag the structure with the mouse to rotate

3D Structures of DNA adenine methylase

Updated on 25-February-2019

1q0s – T4DAM + SAH – Enterobacter phage T4
1q0t, 1yf3, 1yfj – T4DAM + SAH + DNA
1yfl – T4DAM + sinefungin + DNA
2g1p, 4rtk, 4rtn, 4rtq – EcDAM + SAH + DNA – Escherichia coli
2ore, 4gbe – EcDAM + SAH
4gol, 4gom, 4gon, 4goo – EcDAM + Aza-SAM derivative
4rtj, 4rtl, 4rto – EcDAM + sinefungin + DNA
4rtm, 4rtp, 4rtr, 4rts – EcDAM + AdoMet + DNA

References

  1. ↑ Lobner-Olesen A, Skovgaard O, Marinus MG. Dam methylation: coordinating cellular processes. Curr Opin Microbiol. 2005 Apr;8(2):154-60. PMID:15802246 doi:http://dx.doi.org/10.1016/j.mib.2005.02.009
  2. ↑ Yang Z, Horton JR, Zhou L, Zhang XJ, Dong A, Zhang X, Schlagman SL, Kossykh V, Hattman S, Cheng X. Structure of the bacteriophage T4 DNA adenine methyltransferase. Nat Struct Biol. 2003 Oct;10(10):849-55. Epub 2003 Aug 24. PMID:12937411 doi:http://dx.doi.org/10.1038/nsb973

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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