DNA adenine methylase
From Proteopedia
(Difference between revisions)
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DAM uses S-adenosyl-L-homocysteine (AdoHcy, SAH) as methyl donor. | DAM uses S-adenosyl-L-homocysteine (AdoHcy, SAH) as methyl donor. | ||
| - | <scene name='51/517445/Cv/ | + | <scene name='51/517445/Cv/10'>Phage T4 DNA adenine metylase with SAH, DNA and I- ions</scene> |
| - | <scene name='51/517445/Cv/ | + | <scene name='51/517445/Cv/11'>SAH binding site</scene> |
| - | <scene name='51/517445/Cv/ | + | <scene name='51/517445/Cv/12'>DNA binding site</scene> |
| - | <scene name='51/517445/Cv/ | + | <scene name='51/517445/Cv/13'>Iod coordination site</scene> (PDB code [[1q0t]]) <ref>PMID:12937411</ref> |
</StructureSection> | </StructureSection> | ||
Current revision
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3D Structures of DNA adenine methylase
Updated on 25-February-2019
1q0s – T4DAM + SAH – Enterobacter phage T4
1q0t, 1yf3, 1yfj – T4DAM + SAH + DNA
1yfl – T4DAM + sinefungin + DNA
2g1p, 4rtk, 4rtn, 4rtq – EcDAM + SAH + DNA – Escherichia coli
2ore, 4gbe – EcDAM + SAH
4gol, 4gom, 4gon, 4goo – EcDAM + Aza-SAM derivative
4rtj, 4rtl, 4rto – EcDAM + sinefungin + DNA
4rtm, 4rtp, 4rtr, 4rts – EcDAM + AdoMet + DNA
References
- ↑ Lobner-Olesen A, Skovgaard O, Marinus MG. Dam methylation: coordinating cellular processes. Curr Opin Microbiol. 2005 Apr;8(2):154-60. PMID:15802246 doi:http://dx.doi.org/10.1016/j.mib.2005.02.009
- ↑ Yang Z, Horton JR, Zhou L, Zhang XJ, Dong A, Zhang X, Schlagman SL, Kossykh V, Hattman S, Cheng X. Structure of the bacteriophage T4 DNA adenine methyltransferase. Nat Struct Biol. 2003 Oct;10(10):849-55. Epub 2003 Aug 24. PMID:12937411 doi:http://dx.doi.org/10.1038/nsb973
