DNA glycosylase
From Proteopedia
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MutY uses base flipping to twist the mispaired adenine out of the DNA helix and into the MutY active site. MutY contains 2 domains: C-terminal domain and catalytic domain containing a helix-hairpin-helix. | MutY uses base flipping to twist the mispaired adenine out of the DNA helix and into the MutY active site. MutY contains 2 domains: C-terminal domain and catalytic domain containing a helix-hairpin-helix. | ||
| - | *<scene name='44/445369/Cv/ | + | *<scene name='44/445369/Cv/9'>Adenine DNA glycosylase containing Fe4S4 cluster with DNA containing an mispaired adenine 8OG and Ca+2</scene>. |
| - | *<scene name='44/445369/Cv/ | + | *<scene name='44/445369/Cv/10'>Mispaired adenine 8OG binding site</scene>. |
| - | *<scene name='44/445369/Cv/ | + | *<scene name='44/445369/Cv/11'>Fe4S4 cluster binds to 3 Cys residues</scene>. |
| - | *<scene name='44/445369/Cv/ | + | *<scene name='44/445369/Cv/12'>Ca+2 ion coordination site</scene> (PDB code [[1rrs]])<ref>PMID:14961129</ref>. Water molecules shown as red spheres. |
</StructureSection> | </StructureSection> | ||
Revision as of 10:03, 25 February 2019
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3D Structures of DNA glycosylate
Updated on 25-February-2019
References
- ↑ Fromme JC, Banerjee A, Verdine GL. DNA glycosylase recognition and catalysis. Curr Opin Struct Biol. 2004 Feb;14(1):43-9. PMID:15102448 doi:http://dx.doi.org/10.1016/j.sbi.2004.01.003
- ↑ Willetts KE, Rey F, Agostini I, Navarro JM, Baudat Y, Vigne R, Sire J. DNA repair enzyme uracil DNA glycosylase is specifically incorporated into human immunodeficiency virus type 1 viral particles through a Vpr-independent mechanism. J Virol. 1999 Feb;73(2):1682-8. PMID:9882380
- ↑ Fromme JC, Banerjee A, Huang SJ, Verdine GL. Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase. Nature. 2004 Feb 12;427(6975):652-6. PMID:14961129 doi:10.1038/nature02306
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