Albumin

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<StructureSection load='' size='450' side='right' scene='Journal:JBSD:26/Cv/7' caption=''>
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<StructureSection load='' size='350' side='right' scene='Journal:JBSD:26/Cv/7' caption='Human serum albumin (PDB code [[1bm0]])'>
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__TOC__
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==Function==
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'''Albumin''' (Alb) is water-soluble protein. Serum albumin (SA) is the most abundant blood plasma protein. SA serves as carrier of fatty acids, bilirubin, ions and drugs. For details on human serum albumin see<br />
'''Albumin''' (Alb) is water-soluble protein. Serum albumin (SA) is the most abundant blood plasma protein. SA serves as carrier of fatty acids, bilirubin, ions and drugs. For details on human serum albumin see<br />
*[[User:Neeharika Pothuri/Human Serum Albumin]]<br />
*[[User:Neeharika Pothuri/Human Serum Albumin]]<br />
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*[[STRUCTURE 1BM0]].
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*[[Molecular Playground/Human Serum Albumin]]<br />
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=== Investigation on the Site-Selective Binding of Bovine Serum Albumin by Erlotinib Hydrochloride <ref>doi 10.1080/07391102.2012.726532</ref>===
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*[[STRUCTURE 1BM0]]<br />
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*[[Albumin (Hebrew)]].
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== Investigation on the Site-Selective Binding of Bovine Serum Albumin by Erlotinib Hydrochloride <ref>doi 10.1080/07391102.2012.726532</ref>==
The binding mode of <scene name='Journal:JBSD:26/Cv/2'>erlotinib hydrochloride (ET)</scene>, a targeted anticancer drug, to <scene name='Journal:JBSD:26/Cv/8'>bovine serum albumin (BSA)</scene> was investigated through 1H NMR, spectroscopic, thermodynamic and molecular modeling methods. Each subdomain is marked with a different colour (<font color='red'><b>red for subdomain IA</b></font>; <span style="color:orange;background-color:black;font-weight:bold;">orange, IB</span>; <span style="color:cyan;background-color:black;font-weight:bold;">cyan, IIA</span>; <span style="color:yellow;background-color:black;font-weight:bold;">yellow, IIB</span>; <span style="color:lime;background-color:black;font-weight:bold;">green, IIIA</span>; <font color='darkmagenta'><b>darkmagenta, IIIB</b></font>). From these methods, the binding parameters, binding site, binding distance, and conformational changes were obtained. Site marker competitive experiments demonstrated that the <scene name='Journal:JBSD:26/Cv/6'>binding site was located in the hydrophobic pocket of site I (subdomain IIA)</scene>. The docking modeling agreed with the results of the fluorescence and displacement experiments.
The binding mode of <scene name='Journal:JBSD:26/Cv/2'>erlotinib hydrochloride (ET)</scene>, a targeted anticancer drug, to <scene name='Journal:JBSD:26/Cv/8'>bovine serum albumin (BSA)</scene> was investigated through 1H NMR, spectroscopic, thermodynamic and molecular modeling methods. Each subdomain is marked with a different colour (<font color='red'><b>red for subdomain IA</b></font>; <span style="color:orange;background-color:black;font-weight:bold;">orange, IB</span>; <span style="color:cyan;background-color:black;font-weight:bold;">cyan, IIA</span>; <span style="color:yellow;background-color:black;font-weight:bold;">yellow, IIB</span>; <span style="color:lime;background-color:black;font-weight:bold;">green, IIIA</span>; <font color='darkmagenta'><b>darkmagenta, IIIB</b></font>). From these methods, the binding parameters, binding site, binding distance, and conformational changes were obtained. Site marker competitive experiments demonstrated that the <scene name='Journal:JBSD:26/Cv/6'>binding site was located in the hydrophobic pocket of site I (subdomain IIA)</scene>. The docking modeling agreed with the results of the fluorescence and displacement experiments.
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</StructureSection>
 
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__NOTOC__
 
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== 3D Structures of albumin ==
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== 3D Structures of albumin ==
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[[Albumin 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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===Human serum albumin===
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[[1e78]], [[1bm0]], [[1ao6]], [[1uor]], [[4g03]], [[4g04]], [[4k2c]] - hSA – human
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===Human serum albumin binary complex===
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[[2ydf]] – hSA + iophenoxic acid<br />
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[[2xvq]], [[2xvu]], [[2xw0]], [[2xw1]] - hSA + dansyl derivative<br />
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[[3lu6]], [[3ju7]], [[3lu8]], [[2bx8]], [[2bxa]], [[2bxb]], [[2bxc]], [[2bxd]], [[2bxe]], [[2bxf ]], [[2bxg]], [[2bxh]], [[2bxi]], [[2bxk]], [[2bxl]], [[2bxm]], [[2bxn]], [[2bxo]], [[2bxp]], [[2bxq]], [[3lu7]], [[4l8u]], [[4l9q]], [[4la0]], [[4lb2]], [[4lb9]] – hSA + drug<br />
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[[4iw1]], [[4iw2]] – hSA + monosaccharide<br />
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[[3jqz]] – hSA + lidocaine<br />
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[[3jry]] - hSA + sulfate<br />
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[[4emx]] – has + Cl<br />
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[[1n5u]] - hSA + heme<br />
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[[3a73]] - hSA + prostaglandin<br />
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[[2vuf]], [[2vue]] - hSA + bilirubin derivative<br />
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[[1gni]], [[1gnj]], [[1e7h]], [[1e7e]], [[1e7f]], [[1e7i]], [[1bke]], [[1bj5]], [[3tdl]], [[4e99]] - hSA + fatty acid<br />
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[[1hk1]] - hSA + thiroxine<br />
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[[2hk2]], [[1hk3]], [[1hk2]] - hSA (mutant) + thiroxine<br />
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[[1e7a]], [[1e7b]] - hSA + general anesthetic<br />
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[[1tf0]] - hSA + peptostreptococcal albumin-binding protein GA module<br />
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[[2esg]] - hSA + immunoglobulin A1<br />
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[[1ysx]] - hSA + anti-apoptotic ligand – NMR<BR />
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[[4hgk]], [[4hgm]] – hSA + shark antibody<br />
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===Human serum albumin ternary complex===
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[[2xsi]], [[2xvv]], [[2xvw]] – hSA + dansyl derivative + myristic acid<br />
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[[3cx9]] - hSA + lysophospholipid + myristic acid<br />
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[[1e7g]] - hSA + fatty acid + myristic acid<br />
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[[1h9z]], [[1ha2]] - hSA + warfarine + myristic acid<br />
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[[1e7c]] - hSA + general anesthetic + myristic acid<br />
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[[1hk4]] - hSA + thiroxine + myristic acid<br />
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[[1hk5]] - hSA (mutant) + thiroxine + myristic acid<br />
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[[1o9x]] - hSA + hemin + myristic acid<br />
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[[3uiv]] - hSA + amantadine + myristic acid<br />
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[[3b9l]] - hSA + AZT + myristic acid<br />
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[[2i2z]] - hSA + aspirin + myristic acid<br />
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[[2i30]] - hSA + salicylic acid + myristic acid<br />
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[[3b9m]] - hSA + AZT + salicylic acid + myristic acid<br />
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[[2vdb]] - hSA + peptostreptococcal albumin-binding protein GA module + naproxen
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===Other serum albumin===
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[[3v03]], [[4f5s]] - bSA – bovine<br />
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[[3v08]], [[4f5t]], [[4f5u]] – hoSA – horse<br />
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[[3v09]], [[4f5u]] – SA – rabbit<br />
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[[3vvj]] – SA – emu<br />
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[[4j2v]] – hoSA + diiodosalicilate<br />
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[[4jk4]] – bSA + diiodosalicilate<br />
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===Albumin===
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[[1s6d]] – Alb 8 – sunflower – NMR<BR />
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[[1wba]] – Alb 1 – winged bean<br />
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[[1p8b]] – Alb 1 – pea<br />
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[[1psy]] – Alb – castor bean - NMR<br />
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[[3lp9]] – Alb hemopexin domain – ''Lathyrus sativus''<br />
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[[2lvf]] – Alb – Brazil nut
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</StructureSection>
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'''References'''
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human serum albumin (PDB code 1bm0)

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References

  1. ↑ Liu Y, Chen M, Luo Z, Lin J, Song L. Investigation on the site-selective binding of bovine serum albumin by erlotinib hydrochloride. J Biomol Struct Dyn. 2012 Oct 17. PMID:23072300 doi:10.1080/07391102.2012.726532

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Michal Harel, Alexander Berchansky, Jaime Prilusky

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