Aldehyde dehydrogenase

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*<scene name='44/447036/Cv/10'>Dithiothreitol binding</scene>.
*<scene name='44/447036/Cv/10'>Dithiothreitol binding</scene>.
*<scene name='44/447036/Cv/11'>Dimercaptobutane-diol binding</scene>.
*<scene name='44/447036/Cv/11'>Dimercaptobutane-diol binding</scene>.
 +
 +
== 3D Structures of aldehyde dehydrogenase ==
 +
[[Aldehyde dehydrogenase 3D structures]]
 +
</StructureSection>
</StructureSection>
== 3D Structures of Aldehyde dehydrogenase ==
== 3D Structures of Aldehyde dehydrogenase ==
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**[[1a4z]] – bALDH2 NAD-binding domain + NAD<BR />
**[[1a4z]] – bALDH2 NAD-binding domain + NAD<BR />
**[[1bi9]] – rALDH2 + NAD<br />
**[[1bi9]] – rALDH2 + NAD<br />
-
**[[4pxl]] – ALDH2 + NAD - maize<br />
+
**[[4pxl]] – mALDH2 + NAD - maize<br />
 +
**[[4pz2]] – mALDH6 + NAD <br />
 +
**[[6d97]] – mALDH12 + NAD <br />
*ALDH2 ternary complex
*ALDH2 ternary complex
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**[[4qje]] - Betaine-SaALDH (mutant)<br />
**[[4qje]] - Betaine-SaALDH (mutant)<br />
**[[4zxu]], [[4zwl]] - Betaine-SaALDH (mutant) + NAD<br />
**[[4zxu]], [[4zwl]] - Betaine-SaALDH (mutant) + NAD<br />
-
**[[4cbb]] - Betaine-PaALDH - ''Pseudomonas aeruginosa''<br />
+
**[[4cbb]], [[6bpg]] - Betaine-PaALDH - ''Pseudomonas aeruginosa''<br />
 +
**[[6bjp]] - Betaine-PaALDH (mutant)<br />
**[[1a4s]] - Betaine-cALDH - cod<BR />
**[[1a4s]] - Betaine-cALDH - cod<BR />
**[[3vos]], [[3tz6]], [[3vos]] – Aspartate-semi-MtALDH<BR />
**[[3vos]], [[3tz6]], [[3vos]] – Aspartate-semi-MtALDH<BR />
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**[[4qet]] – BcALDH (mutant)<br />
**[[4qet]] – BcALDH (mutant)<br />
**[[5uju]] - BmALDH – ''Burkholderia multivorans''<br />
**[[5uju]] - BmALDH – ''Burkholderia multivorans''<br />
 +
**[[6fk3]], [[6fkv]], [[6fjv]] - TtALDH – ''Thermus thermophilus''<br />
*NAD-dependent ALDH binary complexes
*NAD-dependent ALDH binary complexes
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**[[4qn2]], [[5ez4]], [[5eyu]], [[5dib]] - Betaine-SaALDH (mutant) + NAD<br />
**[[4qn2]], [[5ez4]], [[5eyu]], [[5dib]] - Betaine-SaALDH (mutant) + NAD<br />
**[[1bpw]] - Betaine-cALDH + NAD<BR />
**[[1bpw]] - Betaine-cALDH + NAD<BR />
-
**[[2j6l]] – Aminoadipate-semi-hALDH family 7 + NAD<BR />
+
**[[4zvw]], [[4zvx]] - Aminoadipate-semi-hALDH family 7<br />
 +
**[[2j6l]], [[4zvy]] – Aminoadipate-semi-hALDH family 7 + NAD<BR />
 +
**[[4x0u]] - Aminoadipate-semi-hALDH family 7+ inhibitor<br />
 +
**[[4zuk]] - Aminoadipate-semi-hALDH family 7+ NAD<br />
 +
**[[4zul]] - Aminoadipate-semi-hALDH family 7+ α-aminoadipate<br />
**[[2cfi]] - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin<BR />
**[[2cfi]] - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin<BR />
**[[2nad]] - Formate-PaALDH + NAD <BR />
**[[2nad]] - Formate-PaALDH + NAD <BR />
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**[[5gtk]] – BcALDH + NAD<br />
**[[5gtk]] – BcALDH + NAD<br />
**[[5jfl]] – RpALDH + NAD – ''Rhodopseudomonas palustris''<br />
**[[5jfl]] – RpALDH + NAD – ''Rhodopseudomonas palustris''<br />
 +
**[[6gvs]] – RpALDH + NADP <br />
**[[5jfn]] – RpALDH + CoA <br />
**[[5jfn]] – RpALDH + CoA <br />
 +
**[[6fku]] – TtALDH + NADP <br />
*NAD-dependent ALDH ternary complexes
*NAD-dependent ALDH ternary complexes
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**[[4i3x]] – SmALDH + phosphonoacete + NAD<br />
**[[4i3x]] – SmALDH + phosphonoacete + NAD<br />
**[[5jfm]] – RpALDH + CoA + propionyl-CoA<br />
**[[5jfm]] – RpALDH + CoA + propionyl-CoA<br />
 +
**[[4x0t]] - Aminoadipate-semi-hALDH family 7 + NAD+ inhibitor<br />
*NADP-dependent ALDH
*NADP-dependent ALDH
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**[[1vsu]] – CpGAPDH – ''Cryptosporidium parvum''<br />
**[[1vsu]] – CpGAPDH – ''Cryptosporidium parvum''<br />
**[[1ywg]] – PfGAPDH – ''Plasmodium falciparum''<br />
**[[1ywg]] – PfGAPDH – ''Plasmodium falciparum''<br />
-
**[[3cmc]] - GAPDH – ''Bacillus stearothermophilus''<br />
 
**[[2ep7]] – GAPDH – ''Aquifex aeolicus''<br />
**[[2ep7]] – GAPDH – ''Aquifex aeolicus''<br />
**[[2i5p]] – GAPDH – ''Kluyveromyces marxianus''<br />
**[[2i5p]] – GAPDH – ''Kluyveromyces marxianus''<br />
**[[1obf]] – GAPDH – ''Achromobacter xylosoxidans''<br />
**[[1obf]] – GAPDH – ''Achromobacter xylosoxidans''<br />
**[[1b7g]] – GAPDH – ''Sulfolobus solfataricus''<br />
**[[1b7g]] – GAPDH – ''Sulfolobus solfataricus''<br />
-
**[[2gd1]] – GsGAPDH – ''Geobacillus stearothermophilus''<br />
+
**[[2gd1]], [[3cmc]] – GsGAPDH – ''Geobacillus stearothermophilus''<br />
**[[3e6a]] – OsGAPDH – ''Oryza sativa''<br />
**[[3e6a]] – OsGAPDH – ''Oryza sativa''<br />
**[[4gpd]], [[1gpd]], [[1crw]] – GAPDH – lobster<br />
**[[4gpd]], [[1gpd]], [[1crw]] – GAPDH – lobster<br />
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**[[5mz8]] – PhpALDH 21 + succinate<br />
**[[5mz8]] – PhpALDH 21 + succinate<br />
**[[5n5s]] – PhpALDH 21 + NADP<br />
**[[5n5s]] – PhpALDH 21 + NADP<br />
 +
**[[6mvr]] – LoALDH 16 - ''Loktanella''<br />
 +
**[[6mvu]] – LoALDH 16 (mutant)<br />
 +
**[[6mvs]], [[6mvt]] – LoALDH 16 + NAD<br />
*Antiquitin
*Antiquitin

Revision as of 10:02, 4 March 2019

Aldehyde hydrogenase class 1 tetramer complex with NAD, dithiothreitol and dimercaptobutane-diol, 1o9j

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3D Structures of Aldehyde dehydrogenase

Updated on 04-March-2019

References

  1. ↑ Keller, Markus A.; Zander, Ulrich; Fuchs, Julian E.; Kreutz, Christoph; Watschinger, Katrin et al. (2014). A gatekeeper helix determines the substrate specificity of Sjögren–Larsson Syndrome enzyme fatty aldehyde dehydrogenase. Nature Communications vol. 5.

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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