Alpha-lytic protease

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:31, 6 March 2019) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 2: Line 2:
'''Alpha-lytic protease''' (ALP) is a bacterial serine protease of the chymotrypsin family. ALP is a two-domain enzyme. One domain is a large pro region (residues 1-199) that catalyzes the folding of the protease. The second domain is the protease domain (residues 200-397).<ref>PMID:2611204</ref>
'''Alpha-lytic protease''' (ALP) is a bacterial serine protease of the chymotrypsin family. ALP is a two-domain enzyme. One domain is a large pro region (residues 1-199) that catalyzes the folding of the protease. The second domain is the protease domain (residues 200-397).<ref>PMID:2611204</ref>
-
</StructureSection>
+
*<scene name='55/551214/Cv/4'>ALP protease domain and pro domain complex with benzenesulfonyl fluoride</scene>. Water molecules are shown as red spheres.
 +
*<scene name='55/551214/Cv/5'>Benzenesulfonyl fluoride binding site</scene> (PDB entry [[3pro]]).<ref>PMID:9808037</ref>
== 3D Structures of alpha-lytic protease ==
== 3D Structures of alpha-lytic protease ==
 +
[[Alpha-lytic protease 3D structures]]
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
</StructureSection>
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
-
 
+
-
*ALP protease domain
+
-
 
+
-
**[[2alp]], [[1p09]], [[1tal]], [[2ull]], [[1boq]], [[1ssz]], [[2h5c]], [[1ssx]] – LeALP – ''Lysobacter enzymogenes'' <BR />
+
-
**[[1gba]], [[1gbe]], [[1gbj]], [[3urc]], [[3urd]], [[3ure]], [[1qq4]] – LeALP (mutant) <BR />
+
-
**[[1p01]], [[1p02]], [[1p03]], [[1p04]], [[1p05]], [[1p06]], [[1p10]], [[2lpr]], [[3lpr]], [[5lpr]], [[6lpr]], [[7lpr]], [[8lpr]], [[9lpr]], [[2h5d]] – LeALP + boronic acid inhibitor <BR />
+
-
**[[1gbb]], [[1gbc]], [[1gbd]], [[1gbf]], [[1gbh]], [[1gbi]], [[1gbk]], [[1gbl]], [[1gbm]] – LeALP (mutant) + boronic acid inhibitor <BR />
+
-
**[[1p11]], [[1p12]] – LeALP + phosphonate esther inhibitor <BR />
+
-
**[[3qgj]] – LeALP + peptide <BR />
+
-
 
+
-
*ALP pro region
+
-
 
+
-
**[[2pro]], [[1qrx]] – LeALP pro region <BR />
+
-
**[[1qrw]], [[3m7t]], [[3m7u]] – LeALP pro region (mutant) <BR />
+
-
 
+
-
*ALP pro+protease domains
+
-
 
+
-
**[[3pro]], [[4pro]] – LeALP (mutant) <BR />
+
-
}}
 
== References ==
== References ==
<references/>
<references/>
[[Category: Topic Page]]
[[Category: Topic Page]]

Current revision

Structure of alpha-lytic protease protease domain (green) and pro domain (magenta) complex with benzenesulfonyl fluoride (PDB entry 3pro)

Drag the structure with the mouse to rotate

References

  1. ↑ Bone R, Frank D, Kettner CA, Agard DA. Structural analysis of specificity: alpha-lytic protease complexes with analogues of reaction intermediates. Biochemistry. 1989 Sep 19;28(19):7600-9. PMID:2611204
  2. ↑ Sauter NK, Mau T, Rader SD, Agard DA. Structure of alpha-lytic protease complexed with its pro region. Nat Struct Biol. 1998 Nov;5(11):945-50. PMID:9808037 doi:http://dx.doi.org/10.1038/2919

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Alpha-lytic_protease"
Personal tools