Aminoacyl tRNA Synthetase
From Proteopedia
(Difference between revisions)
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of Aminoacyl tRNA synthetase == | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | |||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *'''Class I aaRS''' | ||
| - | |||
| - | *'''Arg-RS''' | ||
| - | |||
| - | **[[1bs2]] – yArgRS<br /> | ||
| - | **[[3gdz]] – ArgRS residues 1-106 – ''Klebsiella pneumoniae''<br /> | ||
| - | **[[1iq0]] – TtArgRS - ''Thermus thermophilus'' | ||
| - | |||
| - | *''Arg-RS + tRNA'' | ||
| - | |||
| - | **[[2zuf]] - PhArgRS + Arg-tRNA - ''Pyrococcus horikoshii''<br /> | ||
| - | **[[1f7v]] - yArgRS + Arg-tRNA | ||
| - | |||
| - | *''Arg-RS ternary complex'' | ||
| - | |||
| - | **[[1f7u]] – yArgRS + Arg-tRNA + Arg<br /> | ||
| - | **[[2zue]] – PhArgRS + Arg-tRNA + ATP analog | ||
| - | |||
| - | *'''Cys-RS''' | ||
| - | |||
| - | **[[1li5]] - EcCysRS - ''Escherichia coli''<br /> | ||
| - | **[[1li7]] - EcCysRS + Cys<br /> | ||
| - | **[[1u0b]] – EcCysRS + Cys-tRNA | ||
| - | |||
| - | *'''Gln-RS''' | ||
| - | |||
| - | **[[1nyl]]– EcGlnRS<br /> | ||
| - | **[[2gls]], [[1lgr]] – StGlnRS – ''Salmonella typhimurium''<br /> | ||
| - | **[[4p2b]] – GlnRS catalytic domain – ''Toxoplasma gondii''<br /`> | ||
| - | **[[2lgs]] – StGlnRS + Glu<br /> | ||
| - | **[[1qrt]], [[1qru]], [[1qrs]] - EcGlnRS (mutant) + Gln-tRNA<br /> | ||
| - | **[[1gtr]], [[1gts]], [[1gsg]] - EcGlnRS + Gln-tRNA<br /> | ||
| - | **[[1qtq]] - EcGlnRS + Gln-tRNA + Gln analog | ||
| - | |||
| - | *''Gln-RS ternary complex'' | ||
| - | |||
| - | **[[1euq]], [[ 1euy]] – EcGlnRS + Gln-tRNA + Gln-SA<br /> | ||
| - | **[[1exd]] - EcGlnRS + Gln-tRNA (mutant) + AMP | ||
| - | |||
| - | *'''Glu-RS''' | ||
| - | |||
| - | **[[1gln]] – TtGluRS<br /> | ||
| - | **[[2o5r]] - TmGluRS<br /> | ||
| - | **[[3aii]] – GluRS – ''Methanothermobacter thermautotrophicus''<br /> | ||
| - | **[[2ja2]] – MtGluRS – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[4a91]] – EcGluRS<br /> | ||
| - | **[[2hz7]] – DrGluRS – ''Deinococcus radiodurans''<br /> | ||
| - | **[[2hra]] – yGluRS N-terminal | ||
| - | |||
| - | *''Glu-RS + small substrates or analogs'' | ||
| - | |||
| - | **[[3afh]] - TmGluRS + Glu-AMP analog<br /> | ||
| - | **[[2rd2]], [[ 2re8]] – EcGluRS (mutant) + Glu-SA<br /> | ||
| - | **[[2cuz]] – TtGluRS + Glu<br /> | ||
| - | **[[1j09]] - TtGluRS + Glu + ATP<br /> | ||
| - | **[[1n75]] - TtGluRS + ATP<br /> | ||
| - | **[[2fco]] - GluRS residues 2-485 + Glu – ''Synechococcus elongatus'' | ||
| - | |||
| - | *''Glu-RS + tRNA'' | ||
| - | |||
| - | **[[1zjw]] – EcGluRS + Glu-tRNA | ||
| - | |||
| - | *''Glu-RS ternary complex'' | ||
| - | |||
| - | **[[3akz]], [[ 3al0]] – TmGluRS + tRNA + Glu-AMP analog – ''Thermotoga maritima''<br /> | ||
| - | **[[1o0b]], [[ 1o0c]] - EcGluRS + Glu-tRNA + Glu + AMP<br />[[2cv0]], [[ 1n77]] - TtGluRS + Glu + Glu-tRNA<br /> | ||
| - | **[[1n78]] - TtGluRS + Glu-ol + Glu-tRNA<br /> | ||
| - | **[[2cv1]] - TtGluRS + Glu-ol + ATP + Glu-tRNA<br /> | ||
| - | **[[2cv2]] - TtGluRS + Glu-SA + Glu-tRNA<br /> | ||
| - | **[[2hrk]], [[ 2hsm]] - yGluRS N-terminal + GU4 nucleic-binding protein 1<br /> | ||
| - | **[[5bmu]] – hGluRS GST-like domain + EPRS-AIMP3<br /> | ||
| - | |||
| - | *'''Ile-RS''' | ||
| - | |||
| - | **[[1ile]] - TtIleRS<br /> | ||
| - | **[[1wny]], [[ 1udz]] – TtIleRS editing domain | ||
| - | |||
| - | *''Ile-RS + small substrates or analogs''<br /> | ||
| - | |||
| - | **[[1ue0]] - TtIleRS editing domain + Val<br /> | ||
| - | **[[1wnz]] - TtIleS editing domain + Val-adenylate<br /> | ||
| - | **[[1wk8]] - TtIleRS editing domain + Val-SA<br /> | ||
| - | **[[1jzq]] – TtIleS + Ile-adenylate analog<br /> | ||
| - | **[[1jzs]] – TtIleS + antibiotic | ||
| - | |||
| - | *''Ile-RS ternary complex''<br /> | ||
| - | |||
| - | **[[1ffy]], [[ 1qu2]], [[ 1qu3]] - SaIleRS + Ile-tRNA + antibiotic - ''Staphylococcus aureus'' | ||
| - | |||
| - | *'''Leu-RS''' | ||
| - | |||
| - | **[[3o0a]] – AaLeuRS hydrolytic domain – ''Aquifex aeolicus''<br />[[2wfd]] – hLeuRS editing domain – human<br /> | ||
| - | **[[2wfe]] - CaLeuRS editing domain – ''Candida albicans''<br /> | ||
| - | **[[2ajg]] - EcLeuRS editing domain<br /> | ||
| - | **[[1wkb]] – PhLeuRS residues 1-810 | ||
| - | |||
| - | *''Leu-RS + small substrates or analogs''<br /> | ||
| - | |||
| - | **[[2wfg]] - CaLeuRS editing domain + benzoxaborole-AMP<br /> | ||
| - | **[[2v0c]] – TtLeuRS + Leu-SA + benzoxaborole-AMP<br /> | ||
| - | **[[1h3n]] - TtLeuRS + Leu-SA<br /> | ||
| - | **[[1obc]], [[1obh]] – TtLeuRS + substrate analog<br /> | ||
| - | **[[2ajh]], [[2aji]] - EcLeuRS editing domain + aa | ||
| - | |||
| - | *''Leu-RS + tRNA''<br /> | ||
| - | |||
| - | **[[1wz2]] – PhLeuRS Leu-tRNA | ||
| - | |||
| - | *''Leu-RS ternary complex''<br /> | ||
| - | |||
| - | **[[2v0g]] - TtLeuRS + Leu-tRNA + benzoxaborole-AMP<br /> | ||
| - | **[[2bte]], [[ 2byt]] - TtLeuRS + Leu-tRNA + Leu | ||
| - | |||
| - | *'''Lys-RS''' | ||
| - | |||
| - | **[[1irx]] – PhLysRS<br /> | ||
| - | **[[1bbw]] – EcLysRS<br /> | ||
| - | **[[1krs]], [[ 1krt]] – EcLysRS anticodon-binding domain – NMR<br /> | ||
| - | **[[3dsq]] – DhLysRS – ''Desulfitobacterium hafniense''<br /> | ||
| - | **[[3bju]] – hLysRS residues 70-579 | ||
| - | |||
| - | *''Lys-RS + small substrates or analogs''<br /> | ||
| - | |||
| - | **[[3a74]] – GsLysRS + diadenosine tetraphosphate – ''Geobacillus stearothermophilus''<br /> | ||
| - | **[[3e9h]], [[3e9i]] – BsLysRS + Lys-SA - ''Bacillus stearothermophilus''<br /> | ||
| - | **[[1bbu]], [[1e10]], [[1lyl]] – EcLysRS + Lys<br /> | ||
| - | **[[1e1t]] - EcLysRS + Lys-adenylate<br /> | ||
| - | **[[1e22]] - EcLysRS + Lys + AMPPCP<br /> | ||
| - | **[[1e24]] - EcLysRS + Lys + ATP | ||
| - | |||
| - | *''Lys-RS + tRNA''<br /> | ||
| - | |||
| - | **[[2zni]], [[2znj]] – DhLysRS + tRNA | ||
| - | |||
| - | *'''Met-RS''' | ||
| - | |||
| - | **[[1a8h]] – TtMetRS<br /> | ||
| - | **[[1med]], [[1mea]] – EcMetRS Zinc-binding domain - NMR<br /> | ||
| - | **[[1qqt]] - EcMetRS residues 2-552<br /> | ||
| - | **[[2x1l]] - MsMetRS residues 2-515 – ''Mycobacterium smegmatis''<br /> | ||
| - | **[[3h97]] – EcMetRS residues 2-548 (mutant) <br /> | ||
| - | **[[3h9c]] - EcMetRS residues 2-548<br /> | ||
| - | **[[2d54]], [[2d5b]] – TtMetRS (mutant) <br /> | ||
| - | **[[1woy]] – TtMetRS residues 1-500 (mutant) <br /> | ||
| - | **[[2djv]] – hMetRS WHEP-TRS domain – NMR<br /> | ||
| - | **[[1pyb]] – AaMetRS β subunit<br /> | ||
| - | **[[1rqg]] – PaMetRS – ''Pyrococcus abyssi''<br /> | ||
| - | **[[1mkh]] – PaMetRS C-terminal | ||
| - | |||
| - | *''Met-RS + small substrates or analogs''<br /> | ||
| - | |||
| - | **[[3kfl]] – LmMetRS residues 206-747+ Met-adenylate - ''Leishmania major''<br /> | ||
| - | **[[2x1m]] - MsMetRS residues 2-515 + Met<br /> | ||
| - | **[[1p7p]], [[1pfu]], [[1pfv]], [[1pfw]] - EcMetRS residues 2-548 + Met<br /> | ||
| - | **[[1pfy]] - EcMetRS residues 1-551 + Met-SA<br /> | ||
| - | **[[1f4l]] - EcMetRS residues 1-551 + Met<br /> | ||
| - | **[[1pg0]] - EcMetRS residues 1-551 + Met-adenylate<br /> | ||
| - | **[[1pg2]] - EcMetRS residues 1-551 + Met + adenine<br /> | ||
| - | **[[3h99]] - EcMetRS residues 2-548 (mutant) + Met<br /> | ||
| - | **[[3h9b]] - EcMetRS residues 2-548 (mutant) + azidonorleucine<br /> | ||
| - | **[[4dlp]] - BmMetRS + SMet – ''Brucella melitensis''<br /> | ||
| - | **[[4py2]] – BmMetRS + inhibitor<br /> | ||
| - | |||
| - | *''Met-RS + tRNA''<br /> | ||
| - | |||
| - | **[[2csx]] – AaMetRS + Met-tRNA | ||
| - | |||
| - | *''Met-RS + tRNA''<br /> | ||
| - | |||
| - | **[[2ct8]] - AaMetRS + Met-tRNA + Met-SA<br /> | ||
| - | **[[2dxi]] – TtMetRS + tRNA + ATP + Glu-ol | ||
| - | |||
| - | *''Met-RS coplex''<br /> | ||
| - | |||
| - | **[[4bl7]], [[4bvx]], [[4bvy]] - hMetRS N-terminal + elongation factor P18<br /> | ||
| - | **[[2hsn]] - yMetRS N-terminal + GU4 nucleic-binding protein 1 N-terminal | ||
| - | |||
| - | *'''Trp-RS''' | ||
| - | |||
| - | **[[1d2r]] - GsTrpRS<br /> | ||
| - | **[[3prh]] – TrpRS (mutant) – ''Bacillus subtilis''<br /> | ||
| - | **[[3n9i]] – TrpRS – ''Yarsinia pestis''<br /> | ||
| - | **[[3m5w]] – CjTrpRS – ''Campylobacter jejuni''<br /> | ||
| - | **[[3a04]] – ApTrpRS – ''Aeropyrum pernix''<br /> | ||
| - | **[[3hzr]] – EhTrpRS – ''Entamoeba histolytica'' <br /> | ||
| - | **[[3i05]] – TbTrpRS residues 3-389 – ''Trypanosoma brucei''<br /> | ||
| - | **[[3hv0]] – CpTrpRS residues 206-593 – ''Cryptosporidium parvum''<br /> | ||
| - | **[[3foc]] – GlTrpRS – ''Giardia lamblia''<br /> | ||
| - | **[[1o5t]] – hTrpRS catalytic fragment<br /> | ||
| - | **[[1ulh]] – hTrpRS residues 35-424<br /> | ||
| - | **[[2el7]] – TtTrpRS<br /> | ||
| - | **[[2ip1]], [[3kt0]] – yTrpRS – yeast<br /> | ||
| - | **[[2yy5]] – TrpRS – ''Mycoplasma pneumoniae''<br /> | ||
| - | **[[2g36]] – TmTrpRS<br /> | ||
| - | **[[1bks]] – StTrpRS + pyridoxal phosphate | ||
| - | |||
| - | *''Trp-RS + small substrates or analogs''<br /> | ||
| - | |||
| - | **[[3a05]] – ApTrpRS + Trp<br /> | ||
| - | **[[3kt3]] – yTrpRS + Trp-adenylate<br /> | ||
| - | **[[3kt6]], [[3kt8]] – yTrpRS + Trp<br /> | ||
| - | **[[3jxe]] – PhTrpRS + Trp-adenylate<br /> | ||
| - | **[[3fhj]], [[3ghd]] – BsTrpRS + Trp + AMP + Pi<br /> | ||
| - | **[[2quh]] – hTrpRS + Trp<br /> | ||
| - | **[[2qui]] - hTrpRS + Trp-amide + ATP<br /> | ||
| - | **[[2quj]] - hTrpRS + Trp-adenylate<br /> | ||
| - | **[[2quk]] – hTrpRS + ATP<br /> | ||
| - | **[[2ov4]] – GsTrpRS + adenosine tetraphosphate<br /> | ||
| - | **[[1i6k]], [[1i6l]], [[1i6m]] – GsTrpRS + Trp-adenylate<br /> | ||
| - | **[[1yid]], [[2a4m]] – DrTrpRS + ATP<br /> | ||
| - | **[[1yi8]], [[1yia]] – DrTrpRS + Trp<br /> | ||
| - | **[[1mau]] – GsTrpRS + Trp + ATP<br /> | ||
| - | **[[1maw]], [[ 1m83]] - GsTrpRS + ATP<br /> | ||
| - | **[[1mb2]] - GsTrpRS + Trp <br /> | ||
| - | **[[3tze]] - TrpRS + Trp - ''Encephalitozoon cuniculi''<br /> | ||
| - | **[[3tzl]] - CjTrpRS + Trp + ADP<br /> | ||
| - | **[[3sz3]] - TrpRS + Trp - ''Vibrio cholerae''<br /> | ||
| - | **[[6dfu]] - TrpRS + Trp - ''Haemophillus influenzae''<br /> | ||
| - | |||
| - | *''Trp-RS + tRNA''<br /> | ||
| - | |||
| - | **[[2ake]], [[2dr2]] - hTrpRS + Trp-tRNA | ||
| - | |||
| - | *'''Tyr-RS''' | ||
| - | |||
| - | **[[1tya]], [[ 1tyb]], [[ 1tyc]], [[ 1tyd]], [[ 2ts1]] – GsTyrRS<br /> | ||
| - | **[[3qe4]], [[3d6u]], [[3d6v]], [[2pxh]], [[2hgz]], [[1u7d]] – MjTyrRS – ''Methanocaldococcus jannaschii''<br /> | ||
| - | **[[1u7x]], [[4hjr]], [[4hk4]]- MjTyrRS (mutant) <br /> | ||
| - | **[[2jan]] – MtTyrRS<br /> | ||
| - | **[[1y42]] - NcTyrRS – ''Neurospora crassa''<br /> | ||
| - | **[[2cya]] – ApTyrRS<br /> | ||
| - | **[[1n3l]] - hTyrRS residues 1-364<br /> | ||
| - | **[[1r6t]], [[1r6u]] – yTyrRS (mutant) <br /> | ||
| - | **[[1jh3]] – GsTyrRS C-terminal – NMR<br /> | ||
| - | |||
| - | *''Tyr-RS + small substrates or analogs''<br /> | ||
| - | |||
| - | **[[3ts1]] – GsTyrRS + Tyr-adenylate intermediate<br /> | ||
| - | **[[4ts1]] – GsTyrRS + Tyr<br /> | ||
| - | **[[3p0h]], [[3p0i]], [[3p0j]] – LmTyrRS + inhibitor<br /> | ||
| - | **[[3n2y]] – MjTyrRS + tetrazolyl phenylalanine<br /> | ||
| - | **[[2zp1]] – MjTyrRS (mutant) + Tyr<br /> | ||
| - | **[[1zh0]] - MjTyrRS (mutant) + naphthyl-Ala<br /> | ||
| - | **[[1zh6]] - MjTyrRS (mutant) + acetyl-Phe<br /> | ||
| - | **[[2ag6]] - MjTyrRS (mutant) + bromo-Phe<br /> | ||
| - | **[[4hjx]] - MjTyrRS (mutant) + di-fluoro-Tyr<br /> | ||
| - | **[[2yxn]] – EcTyrRS residues 1-322 + azido-Tyr<br /> | ||
| - | **[[1vbm]] – EcTyrRS + Tyr-SA<br /> | ||
| - | **[[1vbn]] – EcTyrRS (mutant) + Tyr-SA<br /> | ||
| - | **[[1wq3]], [[1wq4]] - EcTyrRS (mutant) + Tyr<br /> | ||
| - | **[[1x8x]] – EcTyrRS + Tyr<br /> | ||
| - | **[[2pid]] – hTyrRS residues 28-375 + Tyr-SA<br /> | ||
| - | **[[2j5b]] – TyrRS residues 2-346 + Tyr-ol – ''Acanthamoeba polyphaga'' minivirus<br /> | ||
| - | **[[2dlc]] – yTyrRS + tRNA + Tyr-SA<br /> | ||
| - | **[[2cyb]] – AfTyrRS + Tyr - ''Archaeoglobus fulgidus''<br /> | ||
| - | **[[2cyc]] – PhTyrRS + Tyr<br /> | ||
| - | **[[1q11]] – hTyrRS residues 1-364 + Tyr-ol<br /> | ||
| - | **[[1h3e]] - TtTyrRS + Tyr-tRNA + Tyr-ol + ATP<br /> | ||
| - | **[[1h3f]] - TtTyrRS + Tyr-ol<br /> | ||
| - | **[[1jh3]] – GsTyrRS C-terminal – NMR<br /> | ||
| - | **[[1jii]], [[ 1jij]], [[1jil]], [[1jik]] – SaTyrRS + inhibitor | ||
| - | |||
| - | *''Tyr-RS + tRNA''<br /> | ||
| - | |||
| - | **[[1j1u]] – MjTyrRS + Tyr-tRNA | ||
| - | |||
| - | **[[2rkj]] – NcTyrRS + RNA | ||
| - | |||
| - | *'''Val-RS''' | ||
| - | |||
| - | **[[1iyw]] - TtValRS<br /> | ||
| - | **[[1wk9]], [[ 1wka]] – TtValRS CP1 domain | ||
| - | |||
| - | *''Val-RS ternary complex''<br /> | ||
| - | |||
| - | **[[1ivs]] – TtValRS + Val-SA + Val-tRNA<br /> | ||
| - | **[[1gax]] - TtValRS + Val-adenylate analog + Val-tRNA | ||
| - | |||
| - | *'''Class II aaRS''' | ||
| - | |||
| - | *'''Ala-RS''' | ||
| - | |||
| - | **[[3g98]] – AaAlaRS residues 758-867<br /> | ||
| - | **[[1riq]] - AaAlaRS catalytic fragment<br /> | ||
| - | **[[2zze]], [[ 2zzf]], [[ 1wnu]], [[ 1wxo]], [[ 1v4p]] – PhAlaRS<br /> | ||
| - | **[[2zvf]] – AfAlaRS C-terminal | ||
| - | |||
| - | *''Ala-RS + small substrates or analogs''<br /> | ||
| - | |||
| - | **[[3hxu]], [[3hxv]], [[3hxw]] – EcAlaRS catalytic fragment + aa-adenylate <br /> | ||
| - | **[[3hxz]], [[3hy0]], [[3hy1]] - EcAlaRS catalytic fragment (mutant) + aa-adenylate<br /> | ||
| - | **[[3hxx]] - EcAlaRS catalytic fragment + AMPPCP<br /> | ||
| - | **[[3hxy]] - EcAlaRS catalytic fragment + AMPPCP + Ala-AMP + PCP<br /> | ||
| - | **[[3htz]] - AaAlaRS residues 2-454 + Ser<br /> | ||
| - | **[[1yfr]] – AaAlaRS + ATP<br /> | ||
| - | **[[1yfs]] – AaAlaRS + Ala<br /> | ||
| - | **[[1yft]], [[1ygb]] - AaAlaRS catalytic fragment + aa<br /> | ||
| - | **[[2zzg]] - PhAlaRS + Ala-SA<br / | ||
| - | **[[2ztg]] – AfAlaRS + Ala-SA<br /> | ||
| - | |||
| - | *'''Asp-RS''' | ||
| - | |||
| - | **[[3nen]], [[1b8a]] – TkAspRS - ''Thermococcus kodakarensis''<br /> | ||
| - | **[[3i7f]] – EhAspRS<br /> | ||
| - | **[[1wyd]] – AspRS – ''Sulfolobus tokodaii''<br /> | ||
| - | **[[1eov]] - yAspRS<br /> | ||
| - | **[[1n9w]], [[1l0w]], [[1g51]] – TtAspRS<br /> | ||
| - | **[[1eqr]] – EcAspRS | ||
| - | |||
| - | *''Asp-RS + small substrates or analogs''<br /> | ||
| - | |||
| - | **[[3nel]] – TkAspRS + Asp <br /> | ||
| - | **[[3nem]] - TkAspRS + Asp-adenylate | ||
| - | |||
| - | *''Asp-RS + tRNA''<br /> | ||
| - | |||
| - | **[[3kfu]], [[1efw]] – TtAspRS + tRNA <br /> | ||
| - | **[[1asy]], [[1asz]] – yAspRS + Asp-tRNA | ||
| - | |||
| - | *''Asp-RS ternary complex''<br /> | ||
| - | |||
| - | **[[1il2]], [[1c0a]] – EcAspRS + Asp-tRNA + Asp-adenylate | ||
| - | |||
| - | *'''Asn-RS''' | ||
| - | |||
| - | **[[1x56]] - PhAsnRS <br /> | ||
| - | **[[2kqr]] – BmAsnRS N-terminal – NMR – ''Brugia malayi'' | ||
| - | |||
| - | *''Asn-RS + small substrates or analogs''<br /> | ||
| - | |||
| - | **[[2xti]] – BmAsnRS catalytic fragment + Asn-adenine analog<br /> | ||
| - | **[[2xgt]] - BmAsnRS catalytic fragment + Asn-SA<br /> | ||
| - | **[[1x54]] – PhAsnRS + Asn-adenylate<br /> | ||
| - | **[[1x55]] - PhAsnRS + Asn-SA<br /> | ||
| - | **[[11as]] – EcAsnRS + Asn<br /> | ||
| - | **[[12as]] - EcAsnRS + Asn + AMP | ||
| - | |||
| - | *'''Gly-RS''' | ||
| - | |||
| - | **[[1ati]] – TtGlyRS<br /> | ||
| - | **[[2q5h]] – hGlyRS residues 55-739<br /> | ||
| - | **[[2q5i]] - hGlyRS residues 55-739 (mutant) <br /> | ||
| - | **[[2pme]] – hGlyRS<br /> | ||
| - | **[[2pmf]] – hGlyRS (mutant) <br /> | ||
| - | **[[1j5w]] – TmGlyRS α chain | ||
| - | |||
| - | *''Gly-RS + small substrates or analogs''<br /> | ||
| - | |||
| - | **[[2zt5]], [[ 2zxf]] – hGlyRS residues 55-739 + bis-adenosine tetraphosphate<br /> | ||
| - | **[[2zt6]] - hGlyRS residues 55-739 + AMPCPP<br /> | ||
| - | **[[2zt7]] - hGlyRS residues 55-739 + Gly + ATP<br /> | ||
| - | **[[2zt8]] - hGlyRS residues 55-739 + Gly-AMP analog<br /> | ||
| - | **[[1b76]] – TtGlyRS + ATP<br /> | ||
| - | **[[1ggm]] – TtGlyRS + Gly-adenylate | ||
| - | |||
| - | *'''His-RS''' | ||
| - | |||
| - | **[[3net]] – HisRS – Nostoc<br /> | ||
| - | **[[1h4v]] – TtHisRS<br /> | ||
| - | **[[1qe0]] – SaHisRS<br /> | ||
| - | **[[3hri]] – TbHisRS<br /> | ||
| - | **[[1x59]] – hHisRS WHEP-TRS domain - NMR | ||
| - | |||
| - | *''His-RS + small substrates or analogs''<br /> | ||
| - | |||
| - | **[[3lc0]] – HisRS residues 45-478 + His – ''Trypanosoma cruzi''<br /> | ||
| - | **[[1adj]] – TtHisRS + His <br /> | ||
| - | **[[3hrk]] - TbHisRS + His-adenylate<br /> | ||
| - | **[[2el9]] - EcHisRS + His-SA<br /> | ||
| - | **[[1kmm]], [[1ady]] - EcHisRS + His-adenylate<br /> | ||
| - | **[[1kmn]] - EcHisRS + His-ol + ATP | ||
| - | |||
| - | *'''Phe-RS''' | ||
| - | |||
| - | **[[1pys]] – TtPheRS<br /> | ||
| - | **[[3l4g]], [[ 3cmq]] – hPheRS<br /> | ||
| - | **[[2cxi]] – PhPheRS β chain N-terminal<br />[[3ica]] – PheRS β chain – ''Porphyromonas gingivalis'' | ||
| - | |||
| - | *''Phe-RS + small substrates or analogs''<br /> | ||
| - | |||
| - | **[[3pco]] – EcPheRS + phenylalanine+ AMP<br /> | ||
| - | **[[3hfz]], [[2amc]] – TtPheRS α+β chains + Tyr<br /> | ||
| - | **[[2akw]], [[1b70]] - TtPheRS α+β chains + Phe<br /> | ||
| - | **[[1jjc]], [[1b7y]] - TtPheRS α+β chains + Phe-adenylate<br /> | ||
| - | **[[2aly]] - TtPheRS α+β chains + Phe-SA<br /> | ||
| - | **[[2rhq]], [[2rhs]] – PheRS α+β chains (mutant) + inhibitor – ''Staphylococcus haemolyticus'' | ||
| - | |||
| - | *''Phe-RS + tRNA''<br /> | ||
| - | |||
| - | **[[1eiy]] - TtPheRS α+β chains + Phe-tRNA | ||
| - | |||
| - | *''Phe-RS ternary complex'' | ||
| - | |||
| - | **[[2iy5]] - TtPheRS α+β chains + Phe-ol + Phe-tRNA | ||
| - | |||
| - | *'''Pro-RS''' | ||
| - | |||
| - | **[[1hc7]] – TtProRS<br /> | ||
| - | **[[2i4l]] – RpProRS – ''Rhodopseudomonas palustris''<br /> | ||
| - | **[[1nj2]] - MtProRS – ''Methanothermobacter thermautotrophicus''<br /> | ||
| - | **[[1nj8]] – MjProRS<br /> | ||
| - | **[[4k86]] – hProRS residues 1000-1512 <br /> | ||
| - | |||
| - | *''Pro-RS + small substrates or analogs''<br /> | ||
| - | |||
| - | **[[3ial]] – GlProRS residues 34-542 + Pro-adenylate<br /> | ||
| - | **[[2i4m]], [[2i4n]] – RpProRS + aa-SA<br /> | ||
| - | **[[2i4o]] – RpProRS + ATP<br /> | ||
| - | **[[2j3l]] – EfProRS + Pro-SA – ''Enterococcus faecalis''<br /> | ||
| - | **[[2j3m]] – EfProRS + Pro-ol + ATP<br /> | ||
| - | **[[1nj1]], [[1nj5]], [[1nj6]] – MtProRS + aa-SA<br /> | ||
| - | **[[1h4t]] - TtProRS + Pro | ||
| - | |||
| - | *''Pro-RS ternary complex''<br /> | ||
| - | |||
| - | **[[1h4q]] - TtProRS + Pro-tRNA + Pro-ol<br /> | ||
| - | **[[1h4s]] - TtProRS + Pro-tRNA + Pro-SA<br /> | ||
| - | **[[5f9z]] – CpProRS residues 186-688 + halofuginone + AMPPNP <br /> | ||
| - | **[[5f9y]] – CpProRS residues 186-688 + proline + AMP<br /> | ||
| - | **[[4k87]] – hProRS residues 1000-1512 + proline + adenosine<br /> | ||
| - | **[[4k88]] – hProRS residues 1000-1512 + halofunginone<br /> | ||
| - | |||
| - | *Bifunctional RS (bifunctional glutamate/proline tRNA ligase) | ||
| - | |||
| - | **[[4hvc]] – hEPRS residues 1003-1513 + halofunginone + ATP analog<br /> | ||
| - | **[[5v58]] – hEPRS residues 1003-1513 + AZ-SA<br /> | ||
| - | **[[5vad]] – hEPRS residues 1003-1513 + inhibitor<br /> | ||
| - | **[[5a1n]], [[5a34]], [[5a5h]] – hEPRS GST-like domain + EPRS-AIMP2<br /> | ||
| - | |||
| - | |||
| - | *'''Pyrrolysyl-RS'''; domains – RNA-binding 1-101; catalytic 188-454 | ||
| - | |||
| - | **[[2e3c]] - MmPylRS catalytic domain - ''Methanosarcina mazei''<br /> | ||
| - | **[[3vqw]], [[3vqx]], [[4cs2]] - MmPylRS catalytic domain (mutant)<br /> | ||
| - | **[[3dsq]] – DhPylRS <br /> | ||
| - | |||
| - | *''Pyrrolysyl-RS binary complex'' | ||
| - | |||
| - | **[[3qtc]] – MmPylRS catalytic domain (mutant) + AMP-ATP analog<br /> | ||
| - | **[[2q7e]] - MmPylRS catalytic domain + ATP analog<br /> | ||
| - | **[[2q7g]] - MmPylRS C-terminal+ pyrro-Lys analog+ ATP <br /> | ||
| - | **[[3vqv]] - MmPylRS catalytic domain + AMPPNP <br /> | ||
| - | **[[4bw9]], [[4cs4]], [[5k1p]], [[5k1x]] - MmPylRS catalytic domain (mutant) + AMPPNP <br /> | ||
| - | **[[4bwa]] - MmPylRS catalytic domain (mutant) + adenylated norbornene <br /> | ||
| - | **[[4ch3]], [[4ch4]], [[4ch5]], [[4ch6]] - MmPylRS catalytic domain + adenylated lysine derivative<br /> | ||
| - | **[[4cs3]] - MmPylRS catalytic domain (mutant) + adenylated lysine derivative<br /> | ||
| - | **[[5ud5]] - MmPylRS RNA-binding domain + Pyl-RNA<br /> | ||
| - | **[[5v6x]] - MmPylRS RNA-binding domain (mutant) + Pyl-RNA<br /> | ||
| - | **[[2zni]], [[2znj]] – DhPylRS + tRNA <br /> | ||
| - | |||
| - | *''Pyrrolysyl-RS ternary complex'' | ||
| - | |||
| - | **[[2zce]] - MmPylRS catalytic domain + pyrrolysine + ATP analog<br /> | ||
| - | **[[2q7g]] - MmPylRS catalytic domain + pyrrolysine analog + ATP<br /> | ||
| - | **[[2zim]], [[2q7h]] - MmPylRS catalytic domain + adenylated pyrrolysine + pyrophosphate<br /> | ||
| - | **[[2zio]] - MmPylRS catalytic domain + AlocLys-AMP + ATP analog<br /> | ||
| - | **[[3vqy]] - MmPylRS catalytic domain + butoxycarbonyl lysine + AMPPNP <br /> | ||
| - | **[[4q6g]] - MmPylRS catalytic domain + acetyl lysine + ADPNP <br /> | ||
| - | **[[4tqd]] - MmPylRS catalytic domain + iodo-Phe + ATP <br /> | ||
| - | **[[4tqf]], [[4zib]] - MmPylRS catalytic domain + bromothienylo-Ala + ATP <br /> | ||
| - | **[[2zin]] - MmPylRS catalytic domain + butoxycarbonyl lysine + ATP analog <br /> | ||
| - | |||
| - | *'''Ser-RS''' | ||
| - | |||
| - | **[[3lsq]] – TbSerRS<br /> | ||
| - | **[[1sry]] - TtSerRS<br /> | ||
| - | **[[3err]] – TtSerRS/dynein heavy chain<br /> | ||
| - | **[[2zr3]] – PhSerRS<br /> | ||
| - | **[[2dq3]] – AaSerRS<br /> | ||
| - | **[[2du7]] – MjSerRS<br /> | ||
| - | **[[2odr]] – SerRS – ''Methanococcus maripaludis''<br /> | ||
| - | **[[2cim]] – MbSerRS – ''Methanosarcina barkeri''<br /> | ||
| - | **[[1wle]] – SerRS – bovine | ||
| - | |||
| - | *''Ser-RS + small substrates or analogs''<br /> | ||
| - | |||
| - | **[[2zr2]] – PhSerRS + ATP<br /> | ||
| - | **[[2cj9]] – MbSerRS + Ser-SA<br /> | ||
| - | **[[2cjb]] – MbSerRS + Ser<br /> | ||
| - | **[[2cja]] – MbSerRS + ATP<br /> | ||
| - | **[[1ses]], [[1set]] – TtSerRS + Ser-adenylate analog<br /> | ||
| - | **[[3lss]] – TbSerRS + ATP | ||
| - | |||
| - | *''Ser-RS + tRNA''<br /> | ||
| - | |||
| - | **[[1ser]] – TtSerRS + Ser-tRNA<br /> | ||
| - | **[[2du4]] - AfSerRS + Cys-tRNA | ||
| - | |||
| - | *''Ser-RS ternary complex''<br /> | ||
| - | |||
| - | **[[2du3]] – AfSerRS + Cys-tRNA + phosphoserine<br /> | ||
| - | **[[2du5]], [[2du6]] - AfSerRS (mutant) + Cys-tRNA + phosphoserine | ||
| - | |||
| - | *'''Thr-RS''' | ||
| - | |||
| - | **[[1y2q]] - PaThrRS editing domain<br /> | ||
| - | **[[1wwt]] – hThrRS TGS domain – NMR<br /> | ||
| - | **[[1tje]] - EcThrRS editing domain | ||
| - | |||
| - | *''Thr-RS + small substrates or analogs''<br /> | ||
| - | |||
| - | **[[3pd2]], [[3pd3]], [[3pd4]], [[3pd5]] – PaThrRS editing domain + aa-aminoadenosine<br /> | ||
| - | **[[2hkz]] – PaThrRS editing domain + Ser<br /> | ||
| - | **[[2hl0]], [[2hl1]] - PaThrRS editing domain + Ser-adenylate<br /> | ||
| - | **[[2hl2]] - PaThrRS editing domain + Ser-SA<br /> | ||
| - | **[[1tke]] - EcThrRS editing domain + Ser<br /> | ||
| - | **[[1tkg]] - EcThrRS editing domain + Ser-SA<br /> | ||
| - | **[[1tky]] - EcThrRS editing domain + Ser-adenylate<br /> | ||
| - | **[[1fyf]], [[1evl]] - EcThrRS catalytic and anticodon-binding domains + aa-SA<br /> | ||
| - | **[[1evk]] - EcThrRS catalytic and anticodon-binding domains + Thr<br /> | ||
| - | **[[1nyq]] – SaThrRS + Thr-SA<br /> | ||
| - | **[[1nyr]] – SaThrRS + ATP | ||
| - | |||
| - | *''Thr-RS + tRNA''<br /> | ||
| - | |||
| - | **[[1qf6]] – EcThrRS + Thr-tRNA<br /> | ||
| - | **[[1kog]] – EcThrRS catalytic and anticodon-binding domains + mRNA | ||
| - | |||
| - | *Multifunctional RS | ||
| - | |||
| - | **[[1fyj]] – hRS - NMR | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:59, 12 March 2019
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References
- ↑ Cavarelli J, Moras D. Recognition of tRNAs by aminoacyl-tRNA synthetases. FASEB J. 1993 Jan;7(1):79-86. PMID:8422978
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