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5n2u
From Proteopedia
(Difference between revisions)
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==Influenza D virus nucleoprotein== | ==Influenza D virus nucleoprotein== | ||
| - | <StructureSection load='5n2u' size='340' side='right' caption='[[5n2u]], [[Resolution|resolution]] 2.40Å' scene=''> | + | <StructureSection load='5n2u' size='340' side='right'caption='[[5n2u]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5n2u]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N2U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N2U FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5n2u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_d_virus_(d/bovine/france/2986/2012) Influenza d virus (d/bovine/france/2986/2012)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N2U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N2U FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n2u OCA], [http://pdbe.org/5n2u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n2u RCSB], [http://www.ebi.ac.uk/pdbsum/5n2u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n2u ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1542973 Influenza D virus (D/bovine/France/2986/2012)])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n2u OCA], [http://pdbe.org/5n2u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n2u RCSB], [http://www.ebi.ac.uk/pdbsum/5n2u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n2u ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | This paper focuses on the nucleoprotein (NP) of the newly identified member of the Orthomyxoviridae family, Influenza D virus. To date several X-ray structures of NP of Influenza A (A/NP) and B (B/NP) viruses and of infectious salmon anemia (ISA/NP) virus have been solved. Here we purified, characterized and solved the X-ray structure of the tetrameric D/NP at 2.4 A resolution. The crystal structure of its core is similar to NP of other Influenza viruses. However, unlike A/NP and B/NP which possess a flexible amino-terminal tail containing nuclear localization signals (NLS) for their nuclear import, D/NP possesses a carboxy-terminal tail (D/NPTAIL). We show that D/NPTAIL harbors a bipartite NLS and designed C-terminal truncated mutants to demonstrate the role of D/NPTAIL for nuclear transport. | ||
| + | |||
| + | The structure of the nucleoprotein of Influenza D shows that all Orthomyxoviridae nucleoproteins have a similar NPCORE, with or without a NPTAIL for nuclear transport.,Donchet A, Oliva J, Labaronne A, Tengo L, Miloudi M, C A Gerard F, Mas C, Schoehn G, W H Ruigrok R, Ducatez M, Crepin T Sci Rep. 2019 Jan 24;9(1):600. doi: 10.1038/s41598-018-37306-y. PMID:30679709<ref>PMID:30679709</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5n2u" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Nucleoprotein|Nucleoprotein]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Crepin, T]] | [[Category: Crepin, T]] | ||
[[Category: Labaronne, A]] | [[Category: Labaronne, A]] | ||
Revision as of 12:32, 13 March 2019
Influenza D virus nucleoprotein
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