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4b3n

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Revision as of 13:25, 13 March 2019

Crystal structure of rhesus TRIM5alpha PRY/SPRY domain

Structural highlights

4b3n is a 2 chain structure with sequence from Macmu. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	1anf, 1dmb, 1ez9, 1ezo, 1ezp, 1fqa, 1fqb, 1fqc, 1fqd, 1iud, 1jvx, 1jvy, 1jw4, 1jw5, 1lax, 1lls, 1mdp, 1mdq, 1mpb, 1mpc, 1mpd, 1n3w, 1n3x, 1nl5, 1nmu, 1omp, 1peb, 1r6z, 1svx, 1t0k, 1y4c, 1ytv, 1ziu, 1zjl, 1zkb, 1zmg, 2d21, 2h25, 2vgq, 2xz3, 3mbp, 4auf, 4aug, 4auh, 4mbp
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.

Publication Abstract from PubMed

Tripartite motif protein isoform 5 alpha (TRIM5alpha) is a potent antiviral protein that restricts infection by HIV-1 and other retroviruses. TRIM5alpha recognizes the lattice of the retrovirus capsid through its B30.2 (PRY/SPRY) domain in a species-specific manner. Upon binding, TRIM5alpha induces premature disassembly of the viral capsid and activates the downstream innate immune response. We have determined the crystal structure of the rhesus TRIM5alpha PRY/SPRY domain that reveals essential features for capsid binding. Combined cryo-electron microscopy and biochemical data show that the monomeric rhesus TRIM5alpha PRY/SPRY, but not the human TRIM5alpha PRY/SPRY, can bind to HIV-1 capsid protein assemblies without causing disruption of the capsid. This suggests that the PRY/SPRY domain alone constitutes an important pattern-sensing component of TRIM5alpha that is capable of interacting with viral capsids of different curvatures. Our results provide molecular insights into the mechanisms of TRIM5alpha-mediated retroviral restriction.

Structural insight into HIV-1 capsid recognition by rhesus TRIM5alpha.,Yang H, Ji X, Zhao G, Ning J, Zhao Q, Aiken C, Gronenborn AM, Zhang P, Xiong Y Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18372-7. doi:, 10.1073/pnas.1210903109. Epub 2012 Oct 22. PMID:23091002^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Yang H, Ji X, Zhao G, Ning J, Zhao Q, Aiken C, Gronenborn AM, Zhang P, Xiong Y. Structural insight into HIV-1 capsid recognition by rhesus TRIM5alpha. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18372-7. doi:, 10.1073/pnas.1210903109. Epub 2012 Oct 22. PMID:23091002 doi:http://dx.doi.org/10.1073/pnas.1210903109

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4b3n"

@@ Line 1: / Line 1: @@
 ==Crystal structure of rhesus TRIM5alpha PRY/SPRY domain==
-<StructureSection load='4b3n' size='340' side='right' caption='[[4b3n]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
+<StructureSection load='4b3n' size='340' side='right'caption='[[4b3n]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4b3n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B3N FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4b3n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B3N FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1anf|1anf]], [[1dmb|1dmb]], [[1ez9|1ez9]], [[1ezo|1ezo]], [[1ezp|1ezp]], [[1fqa|1fqa]], [[1fqb|1fqb]], [[1fqc|1fqc]], [[1fqd|1fqd]], [[1iud|1iud]], [[1jvx|1jvx]], [[1jvy|1jvy]], [[1jw4|1jw4]], [[1jw5|1jw5]], [[1lax|1lax]], [[1lls|1lls]], [[1mdp|1mdp]], [[1mdq|1mdq]], [[1mpb|1mpb]], [[1mpc|1mpc]], [[1mpd|1mpd]], [[1n3w|1n3w]], [[1n3x|1n3x]], [[1nl5|1nl5]], [[1nmu|1nmu]], [[1omp|1omp]], [[1peb|1peb]], [[1r6z|1r6z]], [[1svx|1svx]], [[1t0k|1t0k]], [[1y4c|1y4c]], [[1ytv|1ytv]], [[1ziu|1ziu]], [[1zjl|1zjl]], [[1zkb|1zkb]], [[1zmg|1zmg]], [[2d21|2d21]], [[2h25|2h25]], [[2vgq|2vgq]], [[2xz3|2xz3]], [[3mbp|3mbp]], [[4auf|4auf]], [[4aug|4aug]], [[4auh|4auh]], [[4mbp|4mbp]]</td></tr>
@@ Line 23: / Line 23: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
+[[Category: Macmu]]
 [[Category: Ji, X]]
 [[Category: Xiong, Y]]

4b3n

From Proteopedia

Revision as of 13:25, 13 March 2019

Crystal structure of rhesus TRIM5alpha PRY/SPRY domain

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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