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Factor VIII

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[[Factor VIII]] (FVIII) is a blood clotting factor. FVIII is a cofactor for [[Factor IX|factor IXa]]<ref>PMID:2491949</ref> . See also [[Factor VIII (Hebrew)]].
[[Factor VIII]] (FVIII) is a blood clotting factor. FVIII is a cofactor for [[Factor IX|factor IXa]]<ref>PMID:2491949</ref> . See also [[Factor VIII (Hebrew)]].
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<scene name='45/451726/Cv/3'>First Ca coordination site</scene>.
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<scene name='45/451726/Cv/7'>First Ca coordination site</scene>.
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<scene name='45/451726/Cv/4'>Second Ca coordination site</scene>.
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<scene name='45/451726/Cv/8'>Second Ca coordination site</scene>.
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<scene name='45/451726/Cv/5'>First Cu coordination site</scene>.
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<scene name='45/451726/Cv/9'>First Cu coordination site</scene>.
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<scene name='45/451726/Cv/6'>Second Cu coordination site</scene> (PDB code [[2r7e]]).<ref>PMID:17965321</ref>
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<scene name='45/451726/Cv/10'>Second Cu coordination site</scene> (PDB code [[2r7e]]).<ref>PMID:17965321</ref>
== Disease ==
== Disease ==

Revision as of 10:50, 17 March 2019

Glycosylated human Factor VIII. Residues 19-760 (cyan), 1582-2351 (magenta) complex with Ca+2 (green) and Cu+2 (orange) ions (PDB code 2r7e)

Drag the structure with the mouse to rotate

3D Structures of Factor VIII

Updated on 17-March-2019

2r7e, 3cdz, 3j2q, 4bdv – hFVIII – human
3hnb, 3hny, 3hob – hFVIII light chain C2 domain
1d7p - hFVIII light chain C2 domain (mutant)
1cfg, 1fac - hFVIII light chain C2 domain membrane-binding peptide - NMR
1iqd - hFVIII light chain C2 domain (mutant) + monoclonal Fab
4xzu - hFVIII light chain C2 domain + monoclonal Fab
4pt6 - hFVIII discoidin domain
4ki5 - mFVIII light chain C2 domain + monoclonal Fab – mouse
3j2s - hFVIII light chain
5k8d - hFVIII heavy chain + light chain residus 104-329
4mo3 - FVIII light chain C2 domain – pig

References

  1. ↑ White GC 2nd, Shoemaker CB. Factor VIII gene and hemophilia A. Blood. 1989 Jan;73(1):1-12. PMID:2491949
  2. ↑ Shen BW, Spiegel PC, Chang CH, Huh JW, Lee JS, Kim J, Kim YH, Stoddard BL. The tertiary structure and domain organization of coagulation factor VIII. Blood. 2008 Feb 1;111(3):1240-7. Epub 2007 Oct 26. PMID:17965321 doi:10.1182/blood-2007-08-109918

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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