Apoptotic protease-activating factor

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==3D structures of apoptotic protease-activating factor-1==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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[[2ygs]], [[1cy5]], [[2p1h]] – hAPAF-1 CARD domain – human <br />
 
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[[1c15]], [[1cww]] – hAPAF-1 CARD domain – NMR <br />
 
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[[1z6t]] – hAPAF-1 + ADP <br />
 
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[[3ygs]] – hAPAF-1 CARD domain + procaspase 9 <br />
 
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[[4rhw]], [[5wvc]] – hAPAF-1 CARD domain + caspase 9 <br />
 
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[[3j2t]], [[3jbt]] – hAPAF-1 + cytochrome c<br />
 
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[[5juy]], [[5wve]] – hAPAF-1 + caspase 9 + cytochrome c<br />
 
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[[3sfz]] – mAPAF-1 + ADP - mouse <br />
 
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[[3shf]] – mAPAF-1 (mutant) + ADP <br />
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:13, 18 March 2019

Human apoptosis protease-activating factor-1 complex with cytochrome c and caspase 9 forming the apoptosome (PDB entry 5juy)

Drag the structure with the mouse to rotate

References

  1. Riedl SJ, Li W, Chao Y, Schwarzenbacher R, Shi Y. Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature. 2005 Apr 14;434(7035):926-33. PMID:15829969 doi:10.1038/nature03465
  2. Furukawa Y, Sutheesophon K, Wada T, Nishimura M, Saito Y, Ishii H, Furukawa Y. Methylation silencing of the Apaf-1 gene in acute leukemia. Mol Cancer Res. 2005 Jun;3(6):325-34. PMID:15972851 doi:http://dx.doi.org/10.1158/1541-7786.MCR-04-0105
  3. Shalaeva DN, Dibrova DV, Galperin MY, Mulkidjanian AY. Modeling of interaction between cytochrome c and the WD domains of Apaf-1: bifurcated salt bridges underlying apoptosome assembly. Biol Direct. 2015 May 27;10:29. doi: 10.1186/s13062-015-0059-4. PMID:26014357 doi:http://dx.doi.org/10.1186/s13062-015-0059-4

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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