Arginase

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Current revision (11:26, 19 March 2019) (edit) (undo)
 
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</StructureSection>
</StructureSection>
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==3D structures of arginase==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*Arginase
 
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**[[3tf3]] – hArg 1 - human <br />
 
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**[[2ef4]], [[2ef5]], [[2eiv]] – Arg – ''Thermus thermophilus'' <br />
 
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**[[4rhi]], [[4rhj]], [[4rhk]] – TbArg – ''Trypanosoma brucei''<br />
 
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**[[5ynl]] – Arg – ''Glaciozyma antarctica'' <br />
 
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*Mn containing arginase
 
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**[[1rla]], [[2rla]] – rArg + Mn – rat<br />
 
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**[[3rla]], [[4rla]], [[5rla]], [[1hqx]], [[1p8m]], [[1p8n]], [[1p8o]], [[1p8p]], [[1p8q]], [[1p8r]], [[1p8s]], [[1ta1]], [[1tbh]], [[1tbj]], [[1tbl]], [[3e8q]], [[3e8z]] – rArg (mutant) + Mn <br />
 
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**[[1wva]], [[2pha]], [[2zav]] – hArg 1 + Mn <br />
 
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**[[1wvb]] – hArg 1 (mutant) + Mn <br />
 
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**[[1cev]], [[2cev]] – BcArg + Mn – ''Bacillus caldovelox''<br />
 
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**[[6dkt]] – BsArg + Mn – ''Bacillus subtilis''<br />
 
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**[[6nbk]] – Arg + Mn – ''Bacillus cereus''<br />
 
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**[[4g3h]] – Arg + Mn – ''Helicobacter pylori''<br />
 
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**[[4ity]] – LmArg + Mn – ''Leishmania mexicana''<br />
 
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**[[4q3p]] – SmArg + Mn – ''Schistosoma mansoni''<br />
 
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**[[4rhl]], [[4rhm]], [[4rhq]] – TbArg (mutant) + Mn <br />
 
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* ''Mn containing arginase complexes''
 
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**[[1d3v]], [[1hq5]] – rArg + Mn + Arg analog<br />
 
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**[[1hqf]], [[1hqh]] – rArg + Mn + hydroxyl-Arg <br />
 
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**[[1hqg]] – rArg (mutant) + Mn + ornithine + urea<br />
 
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**[[1r1o]], [[1t4p]], [[1t4r]], [[1t4t]], [[1t5f]] – rArg + Mn + inhibior<br />
 
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**[[1t4s]] – rArg + Mn + valine<br />
 
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**[[1t5g]] – rArg + Mn + Arg <br />
 
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**[[1zpe]], [[1zpg]] – rArg (mutant) + Mn + alkylamine derivative<br />
 
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**[[3e9b]] – rArg (mutant) + Mn + Br-ethyl cysteine<br />
 
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**[[2aeb]], [[2pll]] – hArg 1 + Mn + Arg analog<br />
 
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**[[2pho]] – hArg 1 + Mn + thiosemicarbazide<br />
 
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**[[3dj8]] – hArg 1 + Mn + amino-epoxy octanoic acid<br />
 
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**[[3e6k]], [[3e6v]] – hArg 1 (mutant) + Mn + Arg analog<br />
 
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**[[3f80]] – hArg 1 + Mn + nitro-norleucine<br />
 
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**[[3kv2]], [[3lp7]] – hArg 1 + Mn + nor-ω-hydroxy-Arg<br />
 
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**[[3gmz]] – hArg 1 + Mn + ornithine <br />
 
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**[[3gn0]] – hArg 1 + Mn + ornithine derivative<br />
 
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**[[3lp4]] – hArg 1 + Mn + lysine <br />
 
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**[[3mfv]], [[3mfw]] – hArg 1 + Mn + histidine derivative<br />
 
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**[[3mjl]] – hArg 1 + Mn + amino-imidazole<br />
 
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**[[3sjt]], [[3skk]], [[4hww]], [[4hxq]], [[4ie1]] – hArg 1 + Mn + inhibitor<br />
 
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**[[4fci]] – hArg 1 + Mn + amino-guanidino propionate<br />
 
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**[[3cev]] – BcArg + Mn + Arg <br />
 
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**[[5cev]] – BcArg + Mn + Lys <br />
 
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**[[4iu0]], [[4iu1]], [[4iu4]], [[5hj9]], [[5hja]] – LmArg + Mn + inhibitor<br />
 
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**[[4iu5]] – LmArg + Mn + ornithine <br />
 
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**[[4q3q]], [[4q3r]], [[4q3s]], [[4q3t]], [[4q3u]], [[4q3v]] – SmArg + Mn + inhibitor<br />
 
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**[[4q40]], [[4q41]] – SmArg + Mn + amino acid<br />
 
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**[[4q42]] – SmArg + Mn + ornithine <br />
 
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**[[4cev]] – Arg + Mn + ornithine – ''Bacillus caldovelox''<br />
 
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**[[3mmr]], [[3sl0]], [[3sl1]] – Arg + Mn + borohexanoate derivative – ''Plasmodium falciparium'' <br />
 
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*Co containing arginase
 
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**[[3th7]], [[3the]] – hArg 1 + Co <br />
 
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**[[3thh]] – hArg 1 + Co + Arg analog<br />
 
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**[[3thj]] – hArg 1 + Co + ornithine <br />
 
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**[[4fck]] – hArg 1 + Co + amino-guanidino propionate<br />
 
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*Ni containing arginase
 
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**[[4gsm]] – hArg 1 + Ni<br />
 
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**[[4gsv]] – hArg 1 + Ni + Arg analog<br />
 
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*Zn containing arginase
 
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**[[4gsz]] – hArg 1 + Zn + Arg analog<br />
 
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*Mg containing arginase
 
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**[[6nfp]] – BsArg + Mg<br />
 
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*Mn and Zn containing arginase
 
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**[[4gwc]] – hArg 1 + Mn + Zn<br />
 
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**[[4gwd]] – hArg 1 + Mn + Zn + Arg analog<br />
 
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*Arginase 2
 
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**[[1pq3]] – hArg 2+ Mn <br />
 
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**[[4hze]], [[4i06]], [[4ie2]], [[4ie3]], [[4ixu]], [[4ixv]] – hArg 2 + Mn + inhibitor<br />
 
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}}
 
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== References ==
== References ==

Current revision

Structure of rat arginase containing Mn+2 (purple) complex with ornithine (cyan) and urea (yellow) (PDB code 1hqg).

Drag the structure with the mouse to rotate

References

  1. Dowling DP, Di Costanzo L, Gennadios HA, Christianson DW. Evolution of the arginase fold and functional diversity. Cell Mol Life Sci. 2008 Jul;65(13):2039-55. doi: 10.1007/s00018-008-7554-z. PMID:18360740 doi:http://dx.doi.org/10.1007/s00018-008-7554-z
  2. Cox JD, Cama E, Colleluori DM, Pethe S, Boucher JL, Mansuy D, Ash DE, Christianson DW. Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase. Biochemistry. 2001 Mar 6;40(9):2689-701. PMID:11258880

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Michal Harel, Alexander Berchansky

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