Aspartate-semialdehyde dehydrogenase

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ASADH contains 2 domains. The N terminal domain contains the <scene name='45/452498/Cv/7'>active site</scene> and the <scene name='45/452498/Cv/9'>NADP-binding site</scene>. The active site contains a <scene name='45/452498/Cv/10'>cysteine residue</scene> (C134 in ''Vibrio Cholerae'') which binds to inhibitors. The C terminal contains the homodimer intersubunit contacts. <ref>PMID:12493825</ref>
ASADH contains 2 domains. The N terminal domain contains the <scene name='45/452498/Cv/7'>active site</scene> and the <scene name='45/452498/Cv/9'>NADP-binding site</scene>. The active site contains a <scene name='45/452498/Cv/10'>cysteine residue</scene> (C134 in ''Vibrio Cholerae'') which binds to inhibitors. The C terminal contains the homodimer intersubunit contacts. <ref>PMID:12493825</ref>
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== 3D Structures of Aspartate-semialdehyde dehydrogenase ==
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[[Aspartate-semialdehyde dehydrogenase 3D structures]]
</StructureSection>
</StructureSection>
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**[[3q0e]] - VcASADH + cysteine sulfoxide<br />
**[[3q0e]] - VcASADH + cysteine sulfoxide<br />
**[[3q1l]] - SpASADH + cysteamine<br />
**[[3q1l]] - SpASADH + cysteamine<br />
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**[[3tz6]] - MtASADH + cysteine
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**[[3tz6]] - MtASADH + cysteine<br />
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**[[6c85]] - BgASADH + benzoquinone – ''Blastomyces gilchristii''<br />
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**[[6c8w]] - BgASADH + NADP<br />
*ASADH ternary complex
*ASADH ternary complex

Revision as of 11:29, 20 March 2019

Aspartate-semialdehyde dehydrogenase complex with NADP and substrate analog (PDB code 1mb4)

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3D Structures of Aspartate-semialdehyde dehydrogenase

Updated on 20-March-2019

References

  1. Blanco J, Moore RA, Kabaleeswaran V, Viola RE. A structural basis for the mechanism of aspartate-beta-semialdehyde dehydrogenase from Vibrio cholerae. Protein Sci. 2003 Jan;12(1):27-33. PMID:12493825

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Michal Harel, Alexander Berchansky

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