Aspartate-semialdehyde dehydrogenase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:31, 20 March 2019) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 7: Line 7:
== Structural highlights ==
== Structural highlights ==
-
ASADH contains 2 domains. The N terminal domain contains the <scene name='45/452498/Cv/3'>active site</scene> and the <scene name='45/452498/Cv/4'>NADP-binding site</scene>. The active site contains a <scene name='45/452498/Cv/5'>cysteine residue</scene> (C134 in ''Vibrio Cholerae'') which binds to inhibitors. The C terminal contains the homodimer intersubunit contacts. <ref>PMID:12493825</ref>
+
ASADH contains 2 domains. The N terminal domain contains the <scene name='45/452498/Cv/7'>active site</scene> and the <scene name='45/452498/Cv/9'>NADP-binding site</scene>. The active site contains a <scene name='45/452498/Cv/10'>cysteine residue</scene> (C134 in ''Vibrio Cholerae'') which binds to inhibitors. The C terminal contains the homodimer intersubunit contacts. <ref>PMID:12493825</ref>
-
 
+
-
</StructureSection>
+
== 3D Structures of Aspartate-semialdehyde dehydrogenase ==
== 3D Structures of Aspartate-semialdehyde dehydrogenase ==
 +
[[Aspartate-semialdehyde dehydrogenase 3D structures]]
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
</StructureSection>
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
-
 
+
-
*Aspartate-semialdehyde dehydrogenase
+
-
 
+
-
**[[2qz9]], [[1mc4]] – VcASADH II – ''Vibrio cholerae''<br />
+
-
**[[2yv3]] – ASADH – ''Thermus thermiphilus''<br />
+
-
**[[1t4d]], [[1t4b]], [[1brm]] - EcASADH β - ''Escherichia coli''<br />
+
-
**[[1pu2]], [[1oza]], [[1pr3]], [[1ps8]] - HiASADH (mutant) – ''Haemophilus influenzae''<br />
+
-
**[[1nwc]] – HiASADH<br />
+
-
**[[1nwh]] – HiASADH reaction intermediate<br />
+
-
**[[2gyy]] – SpASADH – ''Streptococcus pneumonia''<br />
+
-
**[[3uw3]] - ASADH – ''Burkholderia thailandensis''
+
-
 
+
-
*ASADH binary complex
+
-
 
+
-
**[[2r00]] - VcASADH II + ASA<br />
+
-
**[[3vos]] – MtASADH + glycerol+ anion – ''Mycobacterium tuberculosis''<br />
+
-
**[[3hsk]] – ASADH + NADP – ''Candida albicans''<br />
+
-
**[[1ys4]] - ASADH + NADP – ''Methanocaldococcus jannaschii''<br />
+
-
**[[1nx6]] - HiASADH reaction intermediate +Pi<br />
+
-
**[[1ta4]] - HiASADH + As<br />
+
-
**[[1tb4]] - HiASADH + IO4<br />
+
-
**[[1q2x]] - HiASADH (mutant) + ASA<br />
+
-
**[[2gz1]] - SpASADH + NADP<br />
+
-
**[[2gz2]] - SpASADH + ADP<br />
+
-
**[[3pyl]] - SpASADH + diaminopropionate<br />
+
-
**[[3q0e]] - VcASADH + cysteine sulfoxide<br />
+
-
**[[3q1l]] - SpASADH + cysteamine<br />
+
-
**[[3tz6]] - MtASADH + cysteine
+
-
 
+
-
*ASADH ternary complex
+
-
**[[1pqu]] - HiASADH (mutant) + NADP + cacodylate + substrate analog<br />
 
-
**[[1pqp]] - HiASADH (mutant) + ASA + Pi<br />
 
-
**[[1gl3]] - EcASADH β + NADP + substrate analog<br />
 
-
**[[1mb4]] - VcASADH + NADP + substrate analog<br />
 
-
**[[3pzr]] - VcASADH + NADP + carbamoyl-cysteine <br />
 
-
**[[2gz3]] - SpASADH + NADP + ASA<br />
 
-
**[[3pwk]], [[3pws]] - SpASADH + NADP + aminoadipate<br />
 
-
**[[3pyx]] - SpASADH + NADP + aminoterephthalate <br />
 
-
**[[3pzb]] - SpASADH + NADP + diaminopropionate<br />
 
-
**[[3q11]], [[4r3n]], [[4r3w]], [[4r41]], [[4r4j]], [[4r51]], [[4r54]], [[4r5h]] - SpASADH + NADP + inhibitor<br />
 
-
**[[4r5m]] - VcASADH I + NADP + inhibitor<br />
 
-
}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Aspartate-semialdehyde dehydrogenase complex with NADP and substrate analog (PDB code 1mb4)

Drag the structure with the mouse to rotate

References

  1. ↑ Blanco J, Moore RA, Kabaleeswaran V, Viola RE. A structural basis for the mechanism of aspartate-beta-semialdehyde dehydrogenase from Vibrio cholerae. Protein Sci. 2003 Jan;12(1):27-33. PMID:12493825

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Aspartate-semialdehyde_dehydrogenase"
Personal tools