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Fructokinase

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'''Fructokinase''' (FRK) catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in plants, bacteria and animals. In plants and bacteria FRK regulates starch synthesis. In animals it produces oxalate and its precursors<ref>PMID:3009653</ref>.
'''Fructokinase''' (FRK) catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in plants, bacteria and animals. In plants and bacteria FRK regulates starch synthesis. In animals it produces oxalate and its precursors<ref>PMID:3009653</ref>.
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*<scene name='48/484862/Cv/5'>Fructokinase with ADP and Fructose bound in the active site</scene> ([[3lm9]]). Water molecules shown as red spheres.
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*<scene name='48/484862/Cv/6'>Fructokinase with ADP and fructose bound in the active site</scene> ([[3lm9]]). Water molecules shown as red spheres.
== Relevance ==
== Relevance ==

Revision as of 13:19, 28 March 2019

Fructokinase with ADP and Fructose bound in the active site 3lm9

Drag the structure with the mouse to rotate

3D structures of fructokinase

Updated on 28-March-2019

2qhp – FRK – Bacterioides thetaiotamicron
3ljs – XfFRK – Xylella fastidiosa
3hj6 – FRK – Halothermothrix orenii
3lki – XfFRK + ATP
3lm9 - BsFRK + ATP + fructose – Bacillus subtilis
3ohr - BsFRK + ADP
2v78, 2var – FRK – Sulfolobus solfataricus
3c8u – FRK – Silicibacter
5ey7 – VcFRK – Vibrio cholerae
5f11 – VcFRK + fructose
5f0z – VcFRK + fructose + ADP
5eyn – VcFRK + fructose + ADP + BeF3

References

  1. ↑ James HM, Williams SG, Bais R, Rofe AM, Edwards JB, Conyers RA. The metabolic production of oxalate from xylitol: activities of transketolase, transaldolase, fructokinase and aldolase in liver, kidney, brain, heart and muscle in the rat, mouse, guinea pig, rabbit and human. Int J Vitam Nutr Res Suppl. 1985;28:29-46. PMID:3009653
  2. ↑ Johnson RJ, Rivard C, Lanaspa MA, Otabachian-Smith S, Ishimoto T, Cicerchi C, Cheeke PR, Macintosh B, Hess T. Fructokinase, Fructans, Intestinal Permeability, and Metabolic Syndrome: An Equine Connection? J Equine Vet Sci. 2013 Feb;33(2):120-126. PMID:23439477 doi:http://dx.doi.org/10.1016/j.jevs.2012.05.004
  3. ↑ Phillips MI, Davies DR. The mechanism of guanosine triphosphate depletion in the liver after a fructose load. The role of fructokinase. Biochem J. 1985 Jun 15;228(3):667-71. PMID:2992452

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