Azurin

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<StructureSection load='1joi' size='340' side='right' caption='Structure of azurin containing Cu+2 ion (PDB code [[1joi]]).' scene=''>
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<StructureSection load='1joi' size='350' side='right' caption='Structure of azurin containing Cu+2 ion (PDB code [[1joi]]).' scene='59/593967/Cv/1'>
== Function ==
== Function ==
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'''Azurin''' (AZ) is a blue copper protein. AZ mediates electron transfer and contains type I copper center.
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'''Azurin''' (AZ) is a blue copper protein. AZ mediates electron transfer and contains type I copper center.<br />
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For details see [[Intramolecular Electron Transfer in Azurin]].
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== Disease ==
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== Relevance ==
== Relevance ==
AZ was found to be a novel anticancer agent. Following the entry of the ''P. aeruginosa'' bacteria into human melanoma and breast cancer cells, the AZ complexes with the tumor suppressor p53. The complex stabilizes p53 and activates the apoptosis of the cancer cells.
AZ was found to be a novel anticancer agent. Following the entry of the ''P. aeruginosa'' bacteria into human melanoma and breast cancer cells, the AZ complexes with the tumor suppressor p53. The complex stabilizes p53 and activates the apoptosis of the cancer cells.
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</StructureSection>
 
== Structural highlights ==
== Structural highlights ==
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AZ active Cu binding site is shown here.
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<scene name='59/593967/Cv/3'>AZ active Cu binding site is shown here</scene>. <ref>PMID:8109977</ref>
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==3D structures of cAMP-dependent protein kinase==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Azurin
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**[[1e65]] – PaAZ – ''Pseudomonas aeruginosa''<br />
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*Cu+2 containing azurin
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**[[1azu]], [[1azr]], [[4azu]], [[5azu]], [[1azn]], [[1cc3]], [[1e5y]], [[1e5z]], [[1jze]], [[2ft6]], [[2ft7]], [[2ft8]], [[2fta]], [[3fs9]], [[3fsa]], [[3fsv]], [[3fsw]], [[3fsz]], [[3ft0]] – PaAZ <br />
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**[[3fq2]], [[4hip]], [[4qkt]] – PaAZ (mutant)<br />
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**[[1cuo]], [[1uat]] – AZ – ''Methylomonas''<br />
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**[[1joi]] – PfAZ – ''Pseudomonas fluorrescens''<br />
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**[[1nwo]] – PpAZ – ''Pseudomonas putida''<br />
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**[[1nwp]] – PpAZ + Zn+2<br />
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**[[2aza]], [[1azb]], [[1azc]], [[1rkr]] – AxAZ – ''Achromobacter xylosoxidans''<br />
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**[[1dyz]], [[1dz0]], [[2ccw]] – AZ II – ''Alcaligenes xylosoxidans''<br />
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**[[2azu]], [[3azu]], [[1ils]], [[1ilu]], [[2tsa]], [[2tsb]], [[1etj]], [[1ag0]], [[1ezl]], [[1jvo]], [[1gr7]], [[1xb3]], [[1xb6]], [[1xb8]], [[2ghz]], [[2hx7]], [[2oj1]], [[3in0]], [[3fpy]], [[3fq1]], [3fq2]], [[3fqy]], [[3in2]], [[3jt2]], [[3jtb]], [[3np3]], [[3np4]], [[3oqr]], [[3n2j]], [[3u25]], [[4hhw]], [[4mfh]], [[4ko5]], [[4ko6]], [[4ko7]], [[4ko9]], [[4kob]], [[4koc]], [[4bww]] – PaAZ (mutant) <br />
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**[[1jvl]], [[2idf]] – PaAZ (mutant) + Ni+2<br />
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**[[1uri]], [[1a4a]], [[1a4b]], [[1a4c]] – AdAZ (mutant) <br />
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**[[2h3x]], [[2h47]], [[2iaa]] – AZ + aromatic amine dehydrogenase – ''Alcaligenes faecalis''<br />
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*Cu+2 containing lanthanide-modified azurin
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**[[1bex]], [[1jzi]], [[1jze]], [[1jzf]], [[1jzj]], [[1jzh]] – PaAZ <br />
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**[[2i7s]], [[2fnw]], [[2i7o]], [[3ibo]], [[4hhg]], [[4k9j]] – PaAZ (mutant) <br />
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*Cu+1 containing azurin
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**[[1jzg]] – PaAZ <br />
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**[[1r1c]], [[2gi0]], [[1i53]], [[2hx8]], [[2hx9]], [[2hxa]], [[2xv0]], [[2xv2]], [[2xv3]] – PaAZ (mutant) <br />
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*Other metals-containing azurin
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**[[1aiz]] – AdAZ + Cd+2 – ''Achromobacter denitrificans'' <br />
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**[[1nzr]] – PaAZ (mutant) + Ni+2 <br />
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**[[1vlx]] – PaAZ + Co+2 <br />
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**[[1e67]] – PaAZ + Zn+2<br />
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**[[2iwe]] – PaAZ (mutant) + Zn+2<br />
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**[[3ay2]] – AZ (mutant) + Zn+2 – ''Neisseria Gonorhoeae''<br />
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**[[3uge]] – PaAZ + Ag+1 <br />
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**[[4hz1]] – PaAZ + Fe+2<br />
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**[[4qlw]] – PaAZ (mutant) + Fe+2<br />
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**[[4jkn]] – PaAZ + Hg+2<br />
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}}
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==3D structures of azurin==
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[[Azurin 3D structures]]
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</StructureSection>

Current revision

Structure of azurin containing Cu+2 ion (PDB code 1joi).

Drag the structure with the mouse to rotate


References

  1. ↑ Zhu DW, Dahms T, Willis K, Szabo AG, Lee X. Crystallization and preliminary crystallographic studies of the crystals of the azurin Pseudomonas fluorescens. Arch Biochem Biophys. 1994 Feb 1;308(2):469-70. PMID:8109977 doi:http://dx.doi.org/10.1006/abbi.1994.1066

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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