Baculoviral IAP repeat-containing protein

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:17, 1 April 2019) (edit) (undo)
 
(18 intermediate revisions not shown.)
Line 1: Line 1:
-
<StructureSection load='3d9t' size='340' side='right' caption='Human Baculoviral IAP repeat-containing protein 2 BIR3 domain (grey and green) complex with caspase-9 peptide (pink and yellow) and Zn+2 ions (PDB code [[3d9t]]) ' scene=''>
+
<StructureSection load='' size='350' side='right' caption='Human Baculoviral IAP repeat-containing protein 2 BIR3 domain (magenta) complex with caspase-9 peptide (green) and Zn+2 ion (PDB code [[3d9t]]) ' scene='59/591978/Cv/1'>
== Function ==
== Function ==
 +
 +
'''IAP'''s were discovered in baculoviruses and were shown to be involved in suppressing the host cell response to viral infection. <ref>PMID:9990849</ref><br />
*'''Baculoviral IAP repeat-containing protein 1''' (BIRC1 or NAIP) inhibits the activities of caspase-3,7,9. BIRC1 acts as mediator of neuronal survival in pathological conditions and prevents motor-neuron apoptosis.<br />
*'''Baculoviral IAP repeat-containing protein 1''' (BIRC1 or NAIP) inhibits the activities of caspase-3,7,9. BIRC1 acts as mediator of neuronal survival in pathological conditions and prevents motor-neuron apoptosis.<br />
-
*'''Baculoviral IAP repeat-containing protein 2''' (cIAP1) and Baculoviral IAP repeat-containing protein 3 (cIAP2) inhibit apoptosis by interfering with the activation of caspase and by binding to TNFR-associated factors TRAF1 and TRAF2. cIAP1 is a multi-functional protein which acts as an E3 ubiquitin-protein ligase and plays a role in the modulation of the cell cycle. cIAP1 is involved in controlling b-cell survival under ER stress caused by lipotoxicity. Both cIAP1 and cIAP2 regulate NF-kB activation. cIAP2 inhibits apoptosis caused by serum deprivation but not by inducers of free radicals. cIAPs domains include 3 BIR (zinc-finger found in apoptosis inhibitors) domains, a UBA (Ubiquitin-Associated), CARD (Caspase Recruitment) and RING finger (zinc finger which contains Cys3-His-Cys4 motif) domain.<br />
+
*'''Baculoviral IAP repeat-containing protein 2''' (cIAP1) and '''Baculoviral IAP repeat-containing protein 3''' (cIAP2) inhibit apoptosis by interfering with the activation of caspase and by binding to TNFR-associated factors TRAF1 and TRAF2. cIAP1 is a multi-functional protein which acts as an E3 ubiquitin-protein ligase and plays a role in the modulation of the cell cycle. cIAP1 is involved in controlling b-cell survival under ER stress caused by lipotoxicity. Both cIAP1 and cIAP2 regulate NF-kB activation. cIAP2 inhibits apoptosis caused by serum deprivation but not by inducers of free radicals. <br />
*For '''Baculoviral IAP repeat-containing protein 4''' see XIAP in [[Ubiquitin protein ligase]].<br />
*For '''Baculoviral IAP repeat-containing protein 4''' see XIAP in [[Ubiquitin protein ligase]].<br />
 +
*For '''Baculoviral IAP repeat-containing protein 5''' see [[Survivin]].<br />
*'''Baculoviral IAP repeat-containing protein 6''' (BIRC6) inhibits caspase-3,7,9. Has a role in the final stages of cytokinesis, vescilcle targeting to the site of abscission and ubiquitin conjugation.<br />
*'''Baculoviral IAP repeat-containing protein 6''' (BIRC6) inhibits caspase-3,7,9. Has a role in the final stages of cytokinesis, vescilcle targeting to the site of abscission and ubiquitin conjugation.<br />
*'''Baculoviral IAP repeat-containing protein 7''' or melanoma inhibitor of apoptosis (ML-IAP) contains one BIR and one RING domain. ML-IAP has 2 isoforms. Isoform-a protects cells from staurosporine-induced apoptosis and isoform-b protects cells from etoposide-induced apoptpsis.<br />
*'''Baculoviral IAP repeat-containing protein 7''' or melanoma inhibitor of apoptosis (ML-IAP) contains one BIR and one RING domain. ML-IAP has 2 isoforms. Isoform-a protects cells from staurosporine-induced apoptosis and isoform-b protects cells from etoposide-induced apoptpsis.<br />
Line 12: Line 15:
cIAP1 is a target for intervention against type 2 diabetes. Mutated or deleted BIRC1 were found in individuals with severe muscular atrophy.
cIAP1 is a target for intervention against type 2 diabetes. Mutated or deleted BIRC1 were found in individuals with severe muscular atrophy.
-
</StructureSection>
+
== Relevance ==
-
+
-
== 3D Structures of Baculoviral IAP repeat-containing protein ==
+
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
IAP proteins suppress cell death by inhibiting the activity of caspases. As they are involved in apoptosis regulation, IAPs are of interest in cancer and autoimmune diseases therapy.
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
-
*Baculoviral IAP repeat-containing protein 1 (BIRC1)
+
== Structural highlights ==
-
**[[2vm5]] – hBIRC1 BIR2 domain – human<br />
+
cIAPs domains include 3 BIR (zinc-finger found in apoptosis inhibitors) domains in the N-terminal, a UBA (Ubiquitin-Associated), CARD (Caspase Recruitment) and RING finger (zinc finger which contains Cys3-His-Cys4 motif) domain in the C-terminal.
-
*Baculoviral IAP repeat-containing protein 2 (cIAP1)
+
<scene name='59/591978/Cv/3'>Zinc coordination site</scene> in human Baculoviral IAP repeat-containing protein 2 BIR3 domain (PDB code [[3d9t]])<ref>PMID:15657060</ref>
-
**[[3m1d]] – hcIAP1 BIR1 domain <br />
+
== 3D Structures of Baculoviral IAP repeat-containing protein ==
-
**[[1qbh]] – hcIAP1 BIR3 domain – NMR<br />
+
[[Baculoviral IAP repeat-containing protein 3D structures]]
-
**[[2l9m]] – hcIAP1 CARD domain – NMR<br />
+
-
**[[3t6p]] – hcIAP1 BIR3-RING domain (mutant)<br />
+
-
*cIAP1 complex
+
</StructureSection>
-
 
+
-
**[[3d9t]] – hcIAP1 BIR3 domain + caspase-9 peptide<br />
+
== References ==
-
**[[3d9u]] – hcIAP1 BIR3 domain + SMAC/DIABLO peptide<br />
+
<references/>
-
**[[3mup]], [[3oz1]], [[4eb9]] – hcIAP1 BIR3 domain + SMAC-mimetic<br />
+
[[Category:Topic Page]]
-
**[[3uw4]] – hcIAP1 BIR3 domain (mutant) + anti-cancer peptide<br />
+
-
**[[4hy4]], [[4hy5]], [[4lge]], [[4lgu]], [[4mti]], [[4mu7]], [[4kmn]] – hcIAP1 BIR3 domain + inhibitor<br />
+
-
 
+
-
*Baculoviral IAP repeat-containing protein 3 (cIAP2)
+
-
 
+
-
**[[3eb5]] – hcIAP2 RING domain<br />
+
-
**[[2uvl]] – hcIAP2 BIR3 domain <br />
+
-
 
+
-
*cIAP2 complex
+
-
 
+
-
**[[3eb6]] – hcIAP2 RING domain + ubiquitin-conjugating enzyme E2<br />
+
-
**[[3m0d]] – hcIAP2 BIR1 domain + TNF-associated factor 1 + TNF-associated factor 2 <br />
+
-
**[[3m0a]] – hcIAP2 BIR1 domain + TNF-associated factor 2 <br />
+
-
 
+
-
*Baculoviral IAP repeat-containing protein 6 (BIRC6)
+
-
 
+
-
**[[3ceg]] – hBIRC6 UBA domain <br />
+
-
 
+
-
*Baculoviral IAP repeat-containing protein 7 (ML-IAP)
+
-
 
+
-
**[[1oxn]], [[1oy7]] – hML-IAP BIR domain + peptide inhibitor<br />
+
-
**[[1oxq]] – hML-IAP BIR domain + SMAC peptide inhibitor<br />
+
-
**[[1tw6]], [[2i3h]] – hML-IAP/XIAP BIR domain (mutant) + SMAC peptide inhibitor<br />
+
-
**[[2i3i]], [[3f7g]], [[3f7h]], [[3f7i]], [[3gt9]], [[3gta]] – hML-IAP/XIAP BIR domain (mutant) + peptidomimetic<br />
+
-
**[[3uw5]] – hML-IAP/XIAP BIR domain (mutant) + anti-cancer peptidomimetic<br />
+
-
**[[4auq]] – hML-IAP residues 239-298 + ubiquitin-conjugating enzyme E2 + ubiquitin<br />
+
-
 
+
-
*Baculoviral IAP repeat-containing protein 8 (BIRC8)
+
-
 
+
-
**[[1xb0]], [[1xb1]] – hBIRC8 BIR domain + DIABLO
+
-
}}
+

Current revision

Human Baculoviral IAP repeat-containing protein 2 BIR3 domain (magenta) complex with caspase-9 peptide (green) and Zn+2 ion (PDB code 3d9t)

Drag the structure with the mouse to rotate

References

  1. ↑ Deveraux QL, Reed JC. IAP family proteins--suppressors of apoptosis. Genes Dev. 1999 Feb 1;13(3):239-52. PMID:9990849
  2. ↑ Raina D, Pandey P, Ahmad R, Bharti A, Ren J, Kharbanda S, Weichselbaum R, Kufe D. c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. J Biol Chem. 2005 Mar 25;280(12):11147-51. Epub 2005 Jan 18. PMID:15657060 doi:10.1074/jbc.M413787200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Baculoviral_IAP_repeat-containing_protein"
Personal tools