Beta-lactamase
From Proteopedia
(Difference between revisions)
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The <scene name='45/453531/Cv/3'>active site of class B Blac contains 2 Zn+2 ions</scene>.<ref>PMID:21774017</ref> | The <scene name='45/453531/Cv/3'>active site of class B Blac contains 2 Zn+2 ions</scene>.<ref>PMID:21774017</ref> | ||
| + | |||
| + | == 3D Structures of Beta-lactamase == | ||
| + | [[Beta-lactamase 3D structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of Beta-lactamase == | == 3D Structures of Beta-lactamase == | ||
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*'''β-lactamase class A''' | *'''β-lactamase class A''' | ||
| - | **[[3dtm]], [[1bza]], [[1ck3]], [[1esu]], [[1jwp]], [[1lhy]], [[1li0]], [[1m40]], [[1zg6]], [[2v1z]], [[2v20]], [[3cmz]], [[3jyi]], [[4ibr]], [[4ibx]], [[4mez]], [[4rx2]], [[4rx3]], [[6b2n]], [[5kpu]], [[5iq8]], [[5i63]], [[5i52]], [[5hw5]], [[5hw1]], [[5hvi]] | + | **[[3dtm]], [[1bza]], [[1ck3]], [[1esu]], [[1jwp]], [[1lhy]], [[1li0]], [[1m40]], [[1zg6]], [[2v1z]], [[2v20]], [[3cmz]], [[3jyi]], [[4ibr]], [[4ibx]], [[4mez]], [[4rx2]], [[4rx3]], [[6b2n]], [[5kpu]], [[5iq8]], [[5i63]], [[5i52]], [[5hw5]], [[5hw1]], [[5hvi]], [[6ayk]], [[6apa]] - EcBlac A Tem-1 (mutant) - ''Escherichia coli''<br /> |
| - | **[[1btl]], [[1iys]], [[1xpb]], [[1zg4]], [[4gku]], [[4rva]] - EcBlac A Tem-1<br /> | + | **[[1btl]], [[1iys]], [[1xpb]], [[1zg4]], [[4gku]], [[4rva]], [[5npo]] - EcBlac A Tem-1<br /> |
**[[4r4s]], [[4r4r]], [[4qy6]], [[4qy5]] - EcBlac A Tem-1/PSE-4<br /> | **[[4r4s]], [[4r4r]], [[4qy6]], [[4qy5]] - EcBlac A Tem-1/PSE-4<br /> | ||
**[[1lhy]] - EcBlac A Tem-30 (mutant) <br /> | **[[1lhy]] - EcBlac A Tem-30 (mutant) <br /> | ||
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**[[1tdl]], [[2a3u]], [[3oph]], [[3opl]], [[3v50]], [[3v5m]], [[4fd8]] - KpBlac A Shv-1 (mutant) <br /> | **[[1tdl]], [[2a3u]], [[3oph]], [[3opl]], [[3v50]], [[3v5m]], [[4fd8]] - KpBlac A Shv-1 (mutant) <br /> | ||
**[[1n9b]] – KpBlac A Shv-2<br /> | **[[1n9b]] – KpBlac A Shv-2<br /> | ||
| + | **[[6nfd]] - KpBlac A Shv-11 (mutant) <br /> | ||
**[[5haq]], [[5hap]] - KpBlac A (mutant) <br /> | **[[5haq]], [[5hap]] - KpBlac A (mutant) <br /> | ||
**[[2qpn]] – KpBlac A Ges-1<br /> | **[[2qpn]] – KpBlac A Ges-1<br /> | ||
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**[[1kge]], [[1kgf]], [[1kgg]], [[1ome]] – SaBlac A (mutant) - S''taphylococcus aureus''<br /> | **[[1kge]], [[1kgf]], [[1kgg]], [[1ome]] – SaBlac A (mutant) - S''taphylococcus aureus''<br /> | ||
**[[3blm]] – SaBlac A<br /> | **[[3blm]] – SaBlac A<br /> | ||
| - | **[[1mbl]], [[3ly3]], [[3soi]], [[4n92]], [[5ghx]] – BlBlac A (mutant) – ''Bacillus licheniformis''<br /> | + | **[[1mbl]], [[3ly3]], [[3soi]], [[4n92]], [[5ghx]], [[5zfl]] – BlBlac A (mutant) – ''Bacillus licheniformis''<br /> |
**[[2blm]], [[3sh7]], [[4blm]] – BlBlac A<br /> | **[[2blm]], [[3sh7]], [[4blm]] – BlBlac A<br /> | ||
**[[2cc1]] – Blac A – ''Mycobacterium fortuitum''<br /> | **[[2cc1]] – Blac A – ''Mycobacterium fortuitum''<br /> | ||
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**[[5glc]], [[5gla]], [[5gl9]] - BtBlac A - ''Burkholderia thailandensis''<br /> | **[[5glc]], [[5gla]], [[5gl9]] - BtBlac A - ''Burkholderia thailandensis''<br /> | ||
**[[4yfm]] – Blac – ''Mycobacterium abscessus''<br /> | **[[4yfm]] – Blac – ''Mycobacterium abscessus''<br /> | ||
| + | **[[6ni1]] – BsBlac A – ''Bacillus subtilis''<br /> | ||
| + | **[[6niq]] – Blac A – ''Rhodopseudomonas palustris''<br /> | ||
| + | **[[6nj1]] – Blac A – ''Clostridium kluyveri''<br /> | ||
| + | **[[6b6a]], [[6b6b]], [[6b69]], [[6b68]], [[6b5x]] – MtBlac – ''Mycobacterium tuberculosis''<br /> | ||
*β-lactamase class A binary complex | *β-lactamase class A binary complex | ||
**[[1axb]], [[5ksc]] - EcBlac A (mutant) + transition state analog<br /> | **[[1axb]], [[5ksc]] - EcBlac A (mutant) + transition state analog<br /> | ||
| - | **[[1tem]], [[1bt5]], [[1fqg]], [[1iyo]], [[1iyp]], [[1iyq]], [[1jvj]], [[3q07]], [[3q1f]] - EcBlac A (mutant) + antibiotic<br /> | ||
**[[5ujo]] - EcBlac A (mutant) + organometallics<br /> | **[[5ujo]] - EcBlac A (mutant) + organometallics<br /> | ||
| - | **[[5kmw]] - EcBlac A (mutant) + penicillin derivative<br /> | ||
**[[5fa7]] - EcBlac A + inhibitor<br /> | **[[5fa7]] - EcBlac A + inhibitor<br /> | ||
| - | **[[5chm]], [[5chj]], [[5za2]] – EcBlac FOX-4 + antibiotic<br /> | ||
| - | **[[5cgx]] – EcBlac FOX-4 (mutant) + antibiotic<br /> | ||
| - | **[[4zj3]] – EcBlac Tem (mutant) + antibiotic<br /> | ||
**[[1nxy]], [[1ny0]], [[1nym]], [[1nyy]] - EcBlac A (mutant) + boronic acid inhibitor<br /> | **[[1nxy]], [[1ny0]], [[1nym]], [[1nyy]] - EcBlac A (mutant) + boronic acid inhibitor<br /> | ||
**[[1pzo]], [[1pzp]] - EcBlac A Tem-1 (mutant) + inhibitor<br /> | **[[1pzo]], [[1pzp]] - EcBlac A Tem-1 (mutant) + inhibitor<br /> | ||
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**[[1ong]], [[1q2p]], [[1vm1]], [[2h5s]], [[2zd8]], [[3d4f]], [[3mke]], [[3mkf]], [[3mxr]], [[3mxs]], [[4fh2]], [[4gd6]], [[4gd8]], [[4gdb]], [[4mbf]], [[4r3b]], [[5ee8]], [[4zam]] - KpBlac A Shv-1 + inhibitor<br /> | **[[1ong]], [[1q2p]], [[1vm1]], [[2h5s]], [[2zd8]], [[3d4f]], [[3mke]], [[3mkf]], [[3mxr]], [[3mxs]], [[4fh2]], [[4gd6]], [[4gd8]], [[4gdb]], [[4mbf]], [[4r3b]], [[5ee8]], [[4zam]] - KpBlac A Shv-1 + inhibitor<br /> | ||
**[[1rcj]], [[1tdg]], [[2a49]], [[2h0t]], [[2h0y]], [[2h10]], [[4mbh]], [[4mbk]] - KpBlac A Shv-1 (mutant) + inhibitor<br /> | **[[1rcj]], [[1tdg]], [[2a49]], [[2h0t]], [[2h0y]], [[2h10]], [[4mbh]], [[4mbk]] - KpBlac A Shv-1 (mutant) + inhibitor<br /> | ||
| - | **[[3opp]], [[3opr]]- KpBlac A Shv-1 (mutant) + antibiotic<br /> | ||
**[[5t66]] - KpBlac A + boronic acid inhibitor<br /> | **[[5t66]] - KpBlac A + boronic acid inhibitor<br /> | ||
**[[1w7f]], [[3b3x]], [[2y91]], [[4a5r]] - BlBlac A + inhibitor<br /> | **[[1w7f]], [[3b3x]], [[2y91]], [[4a5r]] - BlBlac A + inhibitor<br /> | ||
**[[3m2j]], [[4n9k]], [[4n9l]] - BlBlac A (mutant) + inhibitor<br /> | **[[3m2j]], [[4n9k]], [[4n9l]] - BlBlac A (mutant) + inhibitor<br /> | ||
| - | **[[2wk0]], [[2x71]]– BlBlac A + antibiotic<br /> | ||
| - | **[[3ly4]], [[3m2k]], [[3sh8]], [[3sh9]], [[5ghz]], [[5ghy]] - BlBlac A (mutant) + antibiotic<br /> | ||
**[[4m3k]], [[4n1h]], [[5lwf]] - BlBlac A + antibody<br /> | **[[4m3k]], [[4n1h]], [[5lwf]] - BlBlac A + antibody<br /> | ||
**[[2q9m]], [[2q9n]] - EncBlac A + inhibitor <br /> | **[[2q9m]], [[2q9n]] - EncBlac A + inhibitor <br /> | ||
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**[[3p98]] – Blac Tem-72 + citrate – ''Morganella morganii''<br /> | **[[3p98]] – Blac Tem-72 + citrate – ''Morganella morganii''<br /> | ||
**[[5tg7]], [[5tg6]], [[5tg5]], [[5tg4]] - AbBlac A + boronic acid inhibitor<br /> | **[[5tg7]], [[5tg6]], [[5tg5]], [[5tg4]] - AbBlac A + boronic acid inhibitor<br /> | ||
| - | **[[5l2f]] - AbBlac A + antibiotic<br /> | ||
**[[5gld]], [[5glb]] - BtBlac A + boronic acid inhibitor <br /> | **[[5gld]], [[5glb]] - BtBlac A + boronic acid inhibitor <br /> | ||
**[[5ne1]] - StmBlac A + boronic acid inhibitor <br /> | **[[5ne1]] - StmBlac A + boronic acid inhibitor <br /> | ||
| + | |||
| + | *β-lactamase class A binary complex with antibiotics | ||
| + | |||
| + | **[[1tem]], [[1bt5]], [[1fqg]], [[1iyo]], [[1iyp]], [[1iyq]], [[1jvj]], [[3q07]], [[3q1f]] - EcBlac A (mutant) + antibiotic<br /> | ||
| + | **[[5kmw]] - EcBlac A (mutant) + penicillin derivative<br /> | ||
| + | **[[5chm]], [[5chj]], [[5za2]] – EcBlac FOX-4 + antibiotic<br /> | ||
| + | **[[5cgx]] – EcBlac FOX-4 (mutant) + antibiotic<br /> | ||
| + | **[[4zj3]] – EcBlac Tem (mutant) + antibiotic<br /> | ||
| + | **[[3opp]], [[3opr]]- KpBlac A Shv-1 (mutant) + antibiotic<br /> | ||
| + | **[[2wk0]], [[2x71]]– BlBlac A + antibiotic<br /> | ||
| + | **[[3ly4]], [[3m2k]], [[3sh8]], [[3sh9]], [[5ghz]], [[5ghy]], [[5zg6]], [[5zft]] – BlBlac A (mutant) + antibiotic<br /> | ||
| + | **[[5l2f]] - AbBlac A + antibiotic<br /> | ||
**[[5ne3]] - StmBlac A + antibiotic <br /> | **[[5ne3]] - StmBlac A + antibiotic <br /> | ||
| + | **[[6dmh]] - SfBlac A (mutant) + antibiotic - ''Serratia fonticola''<br /> | ||
| + | **[[6b6f]], [[6b6e]], [[6b6d]], [[6b6c]], [[6b5y]] – MtBlac + antibiotic<br /> | ||
*Extended-spectrum β-lactamase class A | *Extended-spectrum β-lactamase class A | ||
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**[[3hre]], [[5kmt]], [[5kmu]], [[5kkf]] - EcESBL Ctx-M-9 (mutant)<br /> | **[[3hre]], [[5kmt]], [[5kmu]], [[5kkf]] - EcESBL Ctx-M-9 (mutant)<br /> | ||
**[[4ua6]] – EcESBL Ctx-M-14 <br /> | **[[4ua6]] – EcESBL Ctx-M-14 <br /> | ||
| - | **[[1ylt]], [[5vth]], [[5twd]] - EcBlac A Ctx-M-14 (mutant)<br /> | + | **[[1ylt]], [[5vth]], [[5twd]], [[6cyn]], [[6cyk]] - EcBlac A Ctx-M-14 (mutant)<br /> |
**[[4hbt]] – EcESBL Ctx-M-15<br /> | **[[4hbt]] – EcESBL Ctx-M-15<br /> | ||
**[[1ylw]] - EcESBL Ctx-M-16<br /> | **[[1ylw]] - EcESBL Ctx-M-16<br /> | ||
**[[1ylp]] - EcESBL Ctx-M-27 (mutant)<br /> | **[[1ylp]] - EcESBL Ctx-M-27 (mutant)<br /> | ||
| + | **[[5zb7]] – EcESBL Ctx-M-64<br /> | ||
**[[4c3q]], [[5a93]], [[5a92]], [[5a90]] - EcESBL Ctx-M-97 (mutant)<br /> | **[[4c3q]], [[5a93]], [[5a92]], [[5a90]] - EcESBL Ctx-M-97 (mutant)<br /> | ||
**[[6c78]], [[6c79]], [[6c7a]] - EcESBLToho-1 <br /> | **[[6c78]], [[6c79]], [[6c7a]] - EcESBLToho-1 <br /> | ||
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**[[2qpn]] – KpESBL A GES-1<br /> | **[[2qpn]] – KpESBL A GES-1<br /> | ||
**[[5gs8]] – SmESBL TLA-3 <br /> | **[[5gs8]] – SmESBL TLA-3 <br /> | ||
| + | **[[6bn3]] – SeESBL Ctx-M-151 – ''Salmonela enterica''<br /> | ||
*Extended-spectrum β-lactamase class A binary complex | *Extended-spectrum β-lactamase class A binary complex | ||
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**[[4gog]] - PaESBL A GES-1 + acyl intermediate<br /> | **[[4gog]] - PaESBL A GES-1 + acyl intermediate<br /> | ||
**[[3nia]] - PaESBL A GES-2 + inhibitor<br /> | **[[3nia]] - PaESBL A GES-2 + inhibitor<br /> | ||
| - | **[[4qu3]] - PaESBL A GES-2 + antibiotic<br /> | ||
| - | **[[5eph]], [[5eua]] – PaESBL Bel-1 + antibiotic<br /> | ||
**[[3g2y]], [[3g2z]], [[3g30]], [[3g31]], [[3g32]], [[3g34]], [[3g35]], [[4dds]], [[4ddy]], [[4de0]], [[4de1]], [[4de2]], [[4de3]], [[1yly]], [[1ym1]], [[1yms]] - EcBlac A Ctx-M-9 + inhibitor<br /> | **[[3g2y]], [[3g2z]], [[3g30]], [[3g31]], [[3g32]], [[3g34]], [[3g35]], [[4dds]], [[4ddy]], [[4de0]], [[4de1]], [[4de2]], [[4de3]], [[1yly]], [[1ym1]], [[1yms]] - EcBlac A Ctx-M-9 + inhibitor<br /> | ||
**[[4len]] - EcESBL Ctx-M-9 (mutant) + inhibitor<br /> | **[[4len]] - EcESBL Ctx-M-9 (mutant) + inhibitor<br /> | ||
| - | **[[1ymx]] - EcESBL Ctx-M-9 + antibiotic<br /> | ||
| - | **[[3hlw]], [[3huo]], [[3hvf]] - EcESBL Ctx-M-9 (mutant) + antibiotic<br /> | ||
**[[4uaa]], [[4ua7]] – EcESBL Ctx-M-14 + inhibitor<br /> | **[[4uaa]], [[4ua7]] – EcESBL Ctx-M-14 + inhibitor<br /> | ||
**[[4ua9]], [[1ylz]] – EcESBL Ctx-M-14 + boronic acid inhibitor<br /> | **[[4ua9]], [[1ylz]] – EcESBL Ctx-M-14 + boronic acid inhibitor<br /> | ||
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**[[4hbu]] – EcESBL Ctx-M-15 + inhibitor<br /> | **[[4hbu]] – EcESBL Ctx-M-15 + inhibitor<br /> | ||
**[[4xuz]] - KpBlac A Ctx-M-15 + boronic acid inhibitor<br /> | **[[4xuz]] - KpBlac A Ctx-M-15 + boronic acid inhibitor<br /> | ||
| + | **[[6bu3]] – EcESBL Ctx-M-27 + inhibitor<br /> | ||
**[[4x69]] – EcESBL Ctx-M-44 + inhibitor<br /> | **[[4x69]] – EcESBL Ctx-M-44 + inhibitor<br /> | ||
**[[5g18]] - EcESBL Ctx-M-97 + substrate<br /> | **[[5g18]] - EcESBL Ctx-M-97 + substrate<br /> | ||
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**[[4oq0]], [[4opz]] - EcESBL Tem-94 (mutant) + boronic acid inhibitor<br /> | **[[4oq0]], [[4opz]] - EcESBL Tem-94 (mutant) + boronic acid inhibitor<br /> | ||
**[[4c3q]], [[4opz]] - EcESBL Toho-1 (mutant) + boronic acid inhibitor - Neutron<br /> | **[[4c3q]], [[4opz]] - EcESBL Toho-1 (mutant) + boronic acid inhibitor - Neutron<br /> | ||
| + | **[[5x5g]] – SmESBL TLA-3 + inhibitor<br /> | ||
| + | **[[6bpf]] – SeESBL Ctx-M-151 + inhibitor <br /> | ||
| + | |||
| + | *Extended-spectrum β-lactamase class A binary complex with antibiotics | ||
| + | |||
| + | **[[4qu3]] - PaESBL A GES-2 + antibiotic<br /> | ||
| + | **[[5eph]], [[5eua]] – PaESBL Bel-1 + antibiotic<br /> | ||
| + | **[[1ymx]] - EcESBL Ctx-M-9 + antibiotic<br /> | ||
| + | **[[3hlw]], [[3huo]], [[3hvf]] - EcESBL Ctx-M-9 (mutant) + antibiotic<br /> | ||
| + | **[[4xxr]], [[5u53]], [[5tw6]], [[5twe]], [[6cyu]], [[6cyq]]. [[6bt6]] - EcESBL Ctx-M-14 (mutant) + antibiotic<br /> | ||
**[[4pm9]] - KpBlac A Ctx-M-14 + antibiotic<br /> | **[[4pm9]] - KpBlac A Ctx-M-14 + antibiotic<br /> | ||
**[[4pm5]], [[4pm7]] - KpBlac A Ctx-M-14 (mutant) + antibiotic<br /> | **[[4pm5]], [[4pm7]] - KpBlac A Ctx-M-14 (mutant) + antibiotic<br /> | ||
**[[4s2i]] - KpBlac A Ctx-M-15 + antibiotic<br /> | **[[4s2i]] - KpBlac A Ctx-M-15 + antibiotic<br /> | ||
| - | **[[5x5g]] – SmESBL TLA-3 + inhibitor<br /> | ||
**[[5gwa]] – SmESBL TLA-3 + antibiotic<br /> | **[[5gwa]] – SmESBL TLA-3 + antibiotic<br /> | ||
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**[[3qhv]], [[3qhy]] - Blac A + Protein Blip – ''Bacillus anthracis'' | **[[3qhv]], [[3qhy]] - Blac A + Protein Blip – ''Bacillus anthracis'' | ||
| - | *'''β-lactamase class B (Zn containing)''' | + | *'''β-lactamase class B (Zn containing) or metallo-β-lactamase''' |
**[[3fcz]], [[3i0v]], [[3i11]], [[3i13]], [[3i14]], [[3i15]], [[1bc2]], [[1bvt]], [[1mqo]], [[2bc2]], [[3bc2]], [[1bmc]], [[4c09]], [[4nq4]], [[5fqa]] – BcBlac B - ''Bacillus cereus''<br /> | **[[3fcz]], [[3i0v]], [[3i11]], [[3i13]], [[3i14]], [[3i15]], [[1bc2]], [[1bvt]], [[1mqo]], [[2bc2]], [[3bc2]], [[1bmc]], [[4c09]], [[4nq4]], [[5fqa]] – BcBlac B - ''Bacillus cereus''<br /> | ||
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**[[1k07]] – FgBlac B - ''Fluoribacter gormanii''<br /> | **[[1k07]] – FgBlac B - ''Fluoribacter gormanii''<br /> | ||
**[[1l9y]] - FgBlac B (mutant) <br /> | **[[1l9y]] - FgBlac B (mutant) <br /> | ||
| - | **[[1ko2]], [[1ko3]], [[4bz3]], [[4nq2]] – PaBlac B Vim-2 - ''Pseudomonas aeruginosa''<br /> | + | **[[5n5g]] - PaBlac B Vim-1 - ''Pseudomonas aeruginosa'' <br /> |
| + | **[[1ko2]], [[1ko3]], [[4bz3]], [[4nq2]], [[5yd7]] – PaBlac B Vim-2 - ''Pseudomonas aeruginosa''<br /> | ||
**[[2whg]], [[2wrs]] - PaBlac B Vim-4<br /> | **[[2whg]], [[2wrs]] - PaBlac B Vim-4<br /> | ||
**[[4d1t]] - PaBlac B Vim-7<br /> | **[[4d1t]] - PaBlac B Vim-7<br /> | ||
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**[[4f6h]], [[4f6z]], [[5ls3]] – PaBlac Imp-1 (mutant)<br /> | **[[4f6h]], [[4f6z]], [[5ls3]] – PaBlac Imp-1 (mutant)<br /> | ||
**[[5b3r]] - PaBlac Imp-18 <br /> | **[[5b3r]] - PaBlac Imp-18 <br /> | ||
| - | **[[5ev6]] - SmBlac Imp-1 – ''Serratia marcescens''<br /> | + | **[[5ev6]], [[5y5b]] - SmBlac Imp-1 – ''Serratia marcescens''<br /> |
**[[1wuo]], [[1wup]] - SmBlac Imp-1 (mutant) <br /> | **[[1wuo]], [[1wup]] - SmBlac Imp-1 (mutant) <br /> | ||
**[[3vpe]] - SmBlac Smb-1<br /> | **[[3vpe]] - SmBlac Smb-1<br /> | ||
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**[[3r2u]] – SaBlac B<br /> | **[[3r2u]] – SaBlac B<br /> | ||
**[[3rkj]], [[3sbl]], [[3sfp]], [[3spu]], [[3zr9]], [[3pg4]] - KpBlac B Ndm-1<br /> | **[[3rkj]], [[3sbl]], [[3sfp]], [[3spu]], [[3zr9]], [[3pg4]] - KpBlac B Ndm-1<br /> | ||
| - | **[[3srx]], [[6ex7]] - KpBlac B Ndm-1 | + | **[[3srx]], [[6ex7]] - KpBlac B Ndm-1 + Cd <br /> |
| - | **[[4h0d]] - KpBlac B Ndm-1 | + | **[[4h0d]] - KpBlac B Ndm-1 + Mn<br /> |
| - | **[[5xp6]], [[5n0i]], [[5k4m]], [[5jqj]] - KpBlac B Ndm-1 | + | **[[5xp6]], [[5n0i]], [[5k4m]], [[5jqj]], [[5zgi]], [[5nbk]] - KpBlac B Ndm-1 + Zn<br /> |
| - | **[[5xp9]] - KpBlac B Ndm-1 | + | **[[5zgf]] - KpBlac B Ndm-1 (mutant) + Zn<br /> |
| + | **[[6cac]] - KpBlac B Ndm-1 + Zn + Co + Cd<br /> | ||
| + | **[[5xp9]] - KpBlac B Ndm-1 + Bi<br /> | ||
| + | **[[6mh0]] - KpBlac B Ndm-3 + Zn<br /> | ||
**[[3rkk]], [[4gyq]], [[4gyu]] - KpBlac B Ndm-1 (mutant) <br /> | **[[3rkk]], [[4gyq]], [[4gyu]] - KpBlac B Ndm-1 (mutant) <br /> | ||
| - | **[[5wig]] - KpBlac B Ndm-4 | + | **[[5wig]], [[6mgz]] - KpBlac B Ndm-4 + Zn<br /> |
| + | **[[6mgy]] - KpBlac B Ndm-5 + Zn<br /> | ||
| + | **[[6mgx]] - KpBlac B Ndm-6 + Zn<br /> | ||
**[[5n5g]] - PaBlac B Vim-1<br /> | **[[5n5g]] - PaBlac B Vim-1<br /> | ||
| - | **[[3s0z]] - EcBlac B Ndm-1<br /> | + | **[[3s0z]], [[6c89]] - EcBlac B Ndm-1<br /> |
**[[4tz9]] - EcBlac B Ndm-3<br /> | **[[4tz9]] - EcBlac B Ndm-3<br /> | ||
**[[4tyf]] - EcBlac B Ndm-4<br /> | **[[4tyf]] - EcBlac B Ndm-4<br /> | ||
**[[4tzf]] - EcBlac B Ndm-8<br /> | **[[4tzf]] - EcBlac B Ndm-8<br /> | ||
**[[5wih]] - EcBlac B Ndm-12<br /> | **[[5wih]] - EcBlac B Ndm-12<br /> | ||
| + | **[[6bm9]] – EcBlac B Vim-2<br /> | ||
**[[2yz3]] – Blac Vim-2 – ''Pseudomonas putida''<br /> | **[[2yz3]] – Blac Vim-2 – ''Pseudomonas putida''<br /> | ||
**[[3sd9]] – SfBlac B - ''Serratia fonticola''<br /> | **[[3sd9]] – SfBlac B - ''Serratia fonticola''<br /> | ||
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**[[5ctn]], [[5ctm]] – Blac – ''Bacillus pumilus''<br /> | **[[5ctn]], [[5ctm]] – Blac – ''Bacillus pumilus''<br /> | ||
**[[4ysb]] – Blac + Fe – ''Myxococcus xanthus''<br /> | **[[4ysb]] – Blac + Fe – ''Myxococcus xanthus''<br /> | ||
| + | **[[6cqs]] – Blac + Zn – Sediminispirochaeta smaragdinae<br /> | ||
| + | |||
| + | *β-lactamase class B binary complex with antibiotic | ||
| + | |||
| + | **[[5n5i]] - PaBlac B Vim-1 + antibiotic<br /> | ||
| + | **[[4s2o]], [[5mox]], [[5moz]] - PaBlac Oxa-10 + antibiotic<br /> | ||
| + | **[[5b1u]], [[5b15]], [[5aya]], [[5axo]] - SmBlac Smb-1 + antibiotic<br /> | ||
| + | **[[4zej]] - PsBlac Dim-1 + antibiotic<br /> | ||
| + | 2aio – StmBlac B + antibiotic | ||
| + | 3q6x, 4ey2, 4eyb, 4eyf, 4efl, 4hl1, 4hl2, [[4eyl]], [[4hky]], [[4ram]], [[4raw]], [[4rbs]], [[4rl0]], [[4rl2]], [[5of2]], [[5o2e]] – KpBlac B Ndm-1+ antibiotic | ||
| + | **[[4rm5]] – KpBlac B Ndm-1 (mutant) + antibiotic<br /> | ||
| + | **[[5ypi]], [[5ypk]], [[5ypl]], [[5ypm]], [[5ypn]] – EcBlac B Ndm-1 + antibiotic<br /> | ||
*β-lactamase class B binary complex | *β-lactamase class B binary complex | ||
| Line 234: | Line 275: | ||
**[[1jje]], [[1jjt]], [[3lce]], [[3wxc]], [[4c1f]], [[4c1g]], [[5ndb]] - PaBlac B Imp-1+ inhibitor<br /> | **[[1jje]], [[1jjt]], [[3lce]], [[3wxc]], [[4c1f]], [[4c1g]], [[5ndb]] - PaBlac B Imp-1+ inhibitor<br /> | ||
**[[5n5h]] - PaBlac B Vim-1 + inhibitor<br /> | **[[5n5h]] - PaBlac B Vim-1 + inhibitor<br /> | ||
| - | + | **[[4c1d]], [[4c1e]], [[4pvo]], [[4pvt]], [[4ua4]], [[5lm6]], [[5le1]], [[5lch]], [[5lcf]], [[5lca]], [[5fqc]], [[5acx]], [[5acw]], [[5acv]], [[5acu]], [[5y6d]], [[5nhz]], [[5ni0]], [[5n4s]], [[5n4t]], [[5mxq]], [[5mxr]], [[5k48]], [[6hf5]], [[6ew3]], [[5y6e]], [[5o7n]] - PaBlac B Vim-2 + inhibitor<br /> | |
| - | **[[4c1d]], [[4c1e]], [[4pvo]], [[4pvt]], [[4ua4]], [[5lm6]], [[5le1]], [[5lch]], [[5lcf]], [[5lca]], [[5fqc]], [[5acx]], [[5acw]], [[5acv]], [[5acu]], [[5y6d]], [[5nhz]], [[5ni0]], [[5n4s]], [[5n4t]], [[5mxq]], [[5mxr]], [[5k48]] - PaBlac B Vim-2 + inhibitor<br /> | + | |
**[[5n55]], [[5n58]] - PaBlac B Vim-5 + inhibitor<br /> | **[[5n55]], [[5n58]] - PaBlac B Vim-5 + inhibitor<br /> | ||
**[[5mm9]] - PaBlac B Vim-17 + inhibitor<br /> | **[[5mm9]] - PaBlac B Vim-17 + inhibitor<br /> | ||
| - | **[[4s2o]], [[5mox]], [[5moz]] - PaBlac Oxa-10 + antibiotic<br /> | ||
**[[5fq9]] - PaBlac Oxa-10 + inhibitor<br /> | **[[5fq9]] - PaBlac Oxa-10 + inhibitor<br /> | ||
**[[1m2x]] – Blac B + captopril – ''Elizabethkingia meningoseptica''<br /> | **[[1m2x]] – Blac B + captopril – ''Elizabethkingia meningoseptica''<br /> | ||
**[[1vgn]], [[3vqz]], [[5hh4]], [[5ewa]], [[5ev8]], [[5axr]] - SmBlac Imp-1+ inhibitor<br /> | **[[1vgn]], [[3vqz]], [[5hh4]], [[5ewa]], [[5ev8]], [[5axr]] - SmBlac Imp-1+ inhibitor<br /> | ||
| - | **[[5b1u]], [[5b15]], [[5aya]], [[5axo]] - SmBlac Smb-1 + antibiotic<br /> | ||
**[[2doo]] - SmBlac Imp-1+ fluorescent agent<br /> | **[[2doo]] - SmBlac Imp-1+ fluorescent agent<br /> | ||
| - | **[[4zej]] - PsBlac Dim-1 + antibiotic<br /> | ||
| - | **[[2aio]] – StmBlac B + antibiotic<br /> | ||
**[[2fu8]], [[2fu9]], [[2gfj]], [[2gfk]], [[2hb9]], [[2qdt]], [[5dpx]] - StmBlac B + inhibitor<br /> | **[[2fu8]], [[2fu9]], [[2gfj]], [[2gfk]], [[2hb9]], [[2qdt]], [[5dpx]] - StmBlac B + inhibitor<br /> | ||
**[[3iof]], [[1x8i]], [[3iog]]– AhBlac B (mutant) + inhibitor<br /> | **[[3iof]], [[1x8i]], [[3iog]]– AhBlac B (mutant) + inhibitor<br /> | ||
**[[1x8g]], [[2gkl]], [[2qds]] – AhBlac B + inhibitor<br /> | **[[1x8g]], [[2gkl]], [[2qds]] – AhBlac B + inhibitor<br /> | ||
**[[5wcm]] – BjBlac B + inhibitor<br /> | **[[5wcm]] – BjBlac B + inhibitor<br /> | ||
| - | **[[2m5d]], [[4c1c]], [[4c1h]], [[4nq5]], [[4nq6]], [[5w8w]], [[4tyt]], [[5jmx]] - BcBlac B + inhibitor<br /> | + | **[[2m5d]], [[4c1c]], [[4c1h]], [[4nq5]], [[4nq6]], [[5w8w]], [[4tyt]], [[5jmx]], [[6f2n]], [[6ewe]], [[6eum]] - BcBlac B + inhibitor<br /> |
**[[5ew0]] - SfBlac B + inhibitor<br /> | **[[5ew0]] - SfBlac B + inhibitor<br /> | ||
**[[3q6v]] – SfBlac B + glycerol <br /> | **[[3q6v]] – SfBlac B + glycerol <br /> | ||
| - | **[[ | + | **[[4exy]], [[4exs]], [[4eyl]], [[4hky]], [[4ram]], [[4raw]], [[4rbs]], [[4rl0]], [[4rl2]], [[4u4l]], [[5a5z]], [[5n0h]], [[5zjc]], [[5zj8]], [[5zj7]], [[5zj2]], [[5zj1]], [[5zio]], [[5zh1]], [[5zgz]], [[5zgy]], [[5zgx]], [[5zgw]], [[5zgv]] [[5zgu]], [[5zgt]], [[5zgr]], [[5zgq]], [[5zgp]] – KpBlac B Ndm-1+ inhibitor<br /> |
| - | + | ||
**[[5nai]] – KpBlac B Vim-5 + inhibitor<br /> | **[[5nai]] – KpBlac B Vim-5 + inhibitor<br /> | ||
| - | **[[5ypi]], [[5ypk]], [[5ypl]], [[5ypm]], [[5ypin] – EcBlac B Ndm-1 + antibiotic<br /> | ||
| - | **[[4rm5]] – KpBlac B Ndm-1 (mutant) + antibiotic<br /> | ||
**[[5hh6]], [[5hh5]] - StmBlac B + inhibitor<br /> | **[[5hh6]], [[5hh5]] - StmBlac B + inhibitor<br /> | ||
**[[5fqb]] - BcBlac B + inhibitor<br /> | **[[5fqb]] - BcBlac B + inhibitor<br /> | ||
| Line 264: | Line 297: | ||
*'''β-lactamase class C''' | *'''β-lactamase class C''' | ||
| - | **[[5f1g]], [[5ggw]] – EcBlac C<br /> | + | **[[5f1g]], [[5ggw]], [[6g9t]] – EcBlac C<br /> |
**[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br /> | **[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br /> | ||
| - | **[[1zkj]], [[5f1f]], [[5k1d]], [[5gsc]] – | + | **[[1zkj]], [[5f1f]], [[5k1d]], [[5gsc]] – EaBlac C – ''Enterobacter aerogenes''<br /> |
**[[2qz6]] – Blac C – ''Pseudomonas fluorescens''<br /> | **[[2qz6]] – Blac C – ''Pseudomonas fluorescens''<br /> | ||
**[[3w8k]] – KpBlac C<br /> | **[[3w8k]] – KpBlac C<br /> | ||
**[[4u0t]] – AbBlac C Adc-7<br /> | **[[4u0t]] – AbBlac C Adc-7<br /> | ||
**[[4qd4]] – AbBlac C Adc-68<br /> | **[[4qd4]] – AbBlac C Adc-68<br /> | ||
| + | **[[6fm6]] - AeBlac C Tru-1 – ''Aeromonas enteropelogenes''<br /> | ||
*β-lactamase class C binary complex | *β-lactamase class C binary complex | ||
| Line 284: | Line 318: | ||
**[[1zc2]], [[2zc7]] – KpBlac C + inhibitor<br /> | **[[1zc2]], [[2zc7]] – KpBlac C + inhibitor<br /> | ||
**[[4wbg]] - KpBlac C + antibiotic<br /> | **[[4wbg]] - KpBlac C + antibiotic<br /> | ||
| - | **[[2wzx]], [[2wzz]] – PaBlac C + inhibitor<br /> | + | **[[2wzx]], [[2wzz]], [[6i30]] – PaBlac C + inhibitor<br /> |
**[[4ooy]] - PaBlac C + antibiotic<br /> | **[[4ooy]] - PaBlac C + antibiotic<br /> | ||
**[[4u0x]], [[5wac]], [[5wad]], [[5wae]], [[5waf]], [[5wag]], [[5w12]], [[5w13]], [[5w14]] - AbBlac C Adc-7 + boronic acid inhibitor <br /> | **[[4u0x]], [[5wac]], [[5wad]], [[5wae]], [[5waf]], [[5wag]], [[5w12]], [[5w13]], [[5w14]] - AbBlac C Adc-7 + boronic acid inhibitor <br /> | ||
| + | **[[6fm7]] - AeBlac C Tru-1 + inhibitor <br /> | ||
| + | **[[5k1f]] - EaBlac C + inhibitor <br /> | ||
*'''β-lactamase class D''' | *'''β-lactamase class D''' | ||
| Line 300: | Line 336: | ||
**[[3hbr]] – KpBlac D Oxa-48<br /> | **[[3hbr]] – KpBlac D Oxa-48<br /> | ||
**[[3if6]], [[4s2p]] - KpBlac D Oxa-46<br /> | **[[3if6]], [[4s2p]] - KpBlac D Oxa-46<br /> | ||
| + | **[[6n6w]], [[6n6t]] - AbBlac D Oxa-23 (mutant)<br /> | ||
**[[4zdx]] - AbBlac D Oxa-51<br /> | **[[4zdx]] - AbBlac D Oxa-51<br /> | ||
**[[4y0o]] - AbBlac D Oxa-58<br /> | **[[4y0o]] - AbBlac D Oxa-58<br /> | ||
**[[4s2l]], [[5odz]] - EncBlac D Oxa-163<br /> | **[[4s2l]], [[5odz]] - EncBlac D Oxa-163<br /> | ||
| - | **[[5e2f]] – | + | **[[5e2f]] – BsBlac D <br /> |
**[[4ied]] – Blac – ''Fusobacterium nucleatum''<br /> | **[[4ied]] – Blac – ''Fusobacterium nucleatum''<br /> | ||
| + | **[[6nlw]] – Blac D – ''Shewanella oneidensis''<br /> | ||
| + | **[[6nhs]] – Blac D – ''Nostoc''<br /> | ||
| + | **[[6nhu]] – Blac D – ''Agrobacterium fabrum''<br /> | ||
| + | **[[6ni0]] – BtBlac D <br /> | ||
| + | **[[6n1n]] – Blac D – ''Sebaldella termitidis''<br /> | ||
*β-lactamase class D binary complex | *β-lactamase class D binary complex | ||
| - | **[[1k6r]], [[1k54]] - PaBlac D + antibiotic<br /> | ||
| - | **[[2wgi]], [[2wkh]] - PaBlac D (mutant) + antibiotic<br /> | ||
**[[1k6s]] - PaBlac D + phenylboronic acid<br /> | **[[1k6s]] - PaBlac D + phenylboronic acid<br /> | ||
**[[1dd6]], [[1h5x]], [[1h8y]], [[2wgv]] - PaBlac D + inhibitor<br /> | **[[1dd6]], [[1h5x]], [[1h8y]], [[2wgv]] - PaBlac D + inhibitor<br /> | ||
| Line 316: | Line 356: | ||
**[[3pae]], [[3pag]], [[4f94]] - AbBlac D (mutant) + inhibitor <br /> | **[[3pae]], [[3pag]], [[4f94]] - AbBlac D (mutant) + inhibitor <br /> | ||
**[[3znt]], [[4y0u]], [[4y0t]] - AbBlac D + inhibitor<br /> | **[[3znt]], [[4y0u]], [[4y0t]] - AbBlac D + inhibitor<br /> | ||
| + | **[[6mpq]], [[6b22]] - AbBlac D Oxa-24 + inhibitor<br /> | ||
**[[5vfd]] - AbBlac D Oxa-24 (mutant) + inhibitor<br /> | **[[5vfd]] - AbBlac D Oxa-24 (mutant) + inhibitor<br /> | ||
| + | **[[5fat]], [[5fas]], [[5faq]], [[5fap]], [[5fao]], [[5dva]], [[5dtt]], [[5dts]], [[5dtk]], [[5qa4]], [[5qa5]], [[5qa6]], [[5qa7]], [[5qa8]], [[5qa9]], [[5qaa]], [[5qab]], [[5qac]], [[5qad]], [[5qae]], [[5qaf]], [[5qag]], [[5qah]], [[5qai]], [[5qaj]], [[5qak]], [[5qal]], [[5qam]], [[5qan]], [[5qao]], [[5qap]], [[5qaq]], [[5qar]] [[5qas]], [[5qat]], [[5qau]], [[5qav]], [[5qaw]], [[5qax]], [[5qay]], [[5qaz]], [[5qb0]], [[5qb1]], [[5qb2]], [[5qb3]], [[5qb4]] - KpBlac D Oxa-48 + inhibitor<br /> | ||
| + | |||
| + | *β-lactamase class D binary complex with antibiotics | ||
| + | |||
| + | **[[1k6r]], [[1k54]] - PaBlac D + antibiotic<br /> | ||
| + | **[[2wgi]], [[2wkh]] - PaBlac D (mutant) + antibiotic<br /> | ||
| + | **[[6n6x]], [[6n6y]], [[6n6v]], [[6n6u]] - AbBlac D Oxa-23 (mutant) + antibiotic<br /> | ||
**[[4x56]] - AbBlac D Oxa-160 + antibiotic<br /> | **[[4x56]] - AbBlac D Oxa-160 + antibiotic<br /> | ||
**[[4x53]] - AbBlac D Oxa-160 (mutant) + antibiotic<br /> | **[[4x53]] - AbBlac D Oxa-160 (mutant) + antibiotic<br /> | ||
| Line 322: | Line 370: | ||
**[[4mll]] - KpBlac D Oxa-1 + antibiotic<br /> | **[[4mll]] - KpBlac D Oxa-1 + antibiotic<br /> | ||
**[[4s2j]], [[4s2k]], [[4s2n]], [[4wmc]] - KpBlac D Oxa-48 + antibiotic<br /> | **[[4s2j]], [[4s2k]], [[4s2n]], [[4wmc]] - KpBlac D Oxa-48 + antibiotic<br /> | ||
| - | **[[5fat]], [[5fas]], [[5faq]], [[5fap]], [[5fao]], [[5dva]], [[5dtt]], [[5dts]], [[5dtk]], [[5qa4]], [[5qa5]], [[5qa6]], [[5qa7]], [[5qa8]], [[5qa9]], [[5qaa]], [[5qab]], [[5qac]], [[5qad]], [[5qae]], [[5qaf]], [[5qag]], [[5qah]], [[5qai]], [[5qaj]], [[5qak]], [[5qal]], [[5qam]], [[5qan]], [[5qao]], [[5qap]], [[5qaq]], [[5qar]] [[5qas]], [[5qat]], [[5qau]], [[5qav]], [[5qaw]], [[5qax]], [[5qay]], [[5qaz]], [[5qb0]], [[5qb1]], [[5qb2]], [[5qb3]], [[5qb4]] - KpBlac D Oxa-48 + inhibitor<br /> | ||
*'''AmpC β-lactamase''' | *'''AmpC β-lactamase''' | ||
| Line 333: | Line 380: | ||
**[[1fsw]], [[1fsy]], [[1kds]], [[1kdw]], [[1ke0]], [[1ke3]], [[1mxo]], [[1my8]], [[4e3i]], [[4e3j]], [[4e3k]], [[4e3l]], [[4e3m]], [[4e3n]], [[4e3o]], [[2i72]], [[4lv0]], [[4lv1]], [[4lv2]], [[4lv3]], [[4oqg]] - EcBlac + boronic acid inhibitor<br /> | **[[1fsw]], [[1fsy]], [[1kds]], [[1kdw]], [[1ke0]], [[1ke3]], [[1mxo]], [[1my8]], [[4e3i]], [[4e3j]], [[4e3k]], [[4e3l]], [[4e3m]], [[4e3n]], [[4e3o]], [[2i72]], [[4lv0]], [[4lv1]], [[4lv2]], [[4lv3]], [[4oqg]] - EcBlac + boronic acid inhibitor<br /> | ||
**[[1pi4]], [[1pi5]], [[2ffy]] - EcBlac (mutant) + boronic acid inhibitor<br /> | **[[1pi4]], [[1pi5]], [[2ffy]] - EcBlac (mutant) + boronic acid inhibitor<br /> | ||
| - | **[[1l2s]], [[1xgi]], [[1xgj]], [[2hdq]], [[2hdr]], [[2hds]], [[2hdu]], [[2p9v]], [[2pu2]], [[2pu4]], [[2r9w]], [[2r9x]], [[2rcx]], [[4jxs]], [[4jxv]], [[4jxw]], [[4old]] - EcBlac + inhibitor<br /> | + | **[[1l2s]], [[1xgi]], [[1xgj]], [[2hdq]], [[2hdr]], [[2hds]], [[2hdu]], [[2p9v]], [[2pu2]], [[2pu4]], [[2r9w]], [[2r9x]], [[2rcx]], [[4jxs]], [[4jxv]], [[4jxw]], [[4old]], [[6dpz]], [[6dpy]], [[6dpx]], [[6dpt]] - EcBlac + inhibitor<br /> |
**[[4jxg]] – EcBlac + oxacillin<br /> | **[[4jxg]] – EcBlac + oxacillin<br /> | ||
**[[1o07]], [[4kz9]] - EcBlac (mutant) + inhibitor<br /> | **[[1o07]], [[4kz9]] - EcBlac (mutant) + inhibitor<br /> | ||
| Line 350: | Line 397: | ||
**[[3rxw]], [[3rxx]], [[2ov5]], [[5ul8]] – KpBlac Kpc<br /> | **[[3rxw]], [[3rxx]], [[2ov5]], [[5ul8]] – KpBlac Kpc<br /> | ||
**[[5eec]] - KpBlac Kpc-2 + boronic acid inhibitor<br /> | **[[5eec]] - KpBlac Kpc-2 + boronic acid inhibitor<br /> | ||
| - | **[[4zbe]] - KpBlac Kpc-2 + inhibitor<br /> | + | **[[4zbe]], [[6b1y]], [[6b1x]], [[6b1w]], [[6b1j]], [[6b1h]], [[6b1f]] - KpBlac Kpc-2 + inhibitor<br /> |
**[[5uj3]], [[5uj4]] - KpBlac Kpc-2 + antibiotic<br /> | **[[5uj3]], [[5uj4]] - KpBlac Kpc-2 + antibiotic<br /> | ||
**[[5mgi]] - KoBlac Kpc-2 + boronic acid inhibitor - ''Klebsiella oxytoca'' <br /> | **[[5mgi]] - KoBlac Kpc-2 + boronic acid inhibitor - ''Klebsiella oxytoca'' <br /> | ||
**[[4eqi]] – SfBlac Sfc-1<br /> | **[[4eqi]] – SfBlac Sfc-1<br /> | ||
**[[4euz]], [[4ev4]] – SfBlac Sfc-1 (mutant) + antibiotic<br /> | **[[4euz]], [[4ev4]] – SfBlac Sfc-1 (mutant) + antibiotic<br /> | ||
| - | **[[4jf5]], [[4jf6]] - AbBlac | + | **[[4jf5]], [[4jf6]] - AbBlac Oxa-23 <br /> |
| - | **[[4jf4]] - AbBlac | + | **[[4jf4]] - AbBlac Oxa-23 + antibiotic<br /> |
| - | **[[4oh0]], [[4z9q]] - AbBlac | + | **[[4oh0]], [[4z9q]] - AbBlac Oxa-58 <br /> |
| - | **[[5boh]] - AbBlac | + | **[[5boh]] - AbBlac Oxa-58 (mutant)<br /> |
| - | **[[5iy2]] - AbBlac | + | **[[5iy2]] - AbBlac Oxa-143 <br /> |
**[[1bue]] – EncBlac<br /> | **[[1bue]] – EncBlac<br /> | ||
**[[4tze]], [[4tzb]] - EcBlac Ndm-5<br /> | **[[4tze]], [[4tzb]] - EcBlac Ndm-5<br /> | ||
**[[3dw0]], [[3c5a]] - EcBlac Kpc-2 <br /> | **[[3dw0]], [[3c5a]] - EcBlac Kpc-2 <br /> | ||
**[[5ll7]] - EcBlac Kpc-2 + boronic acid inhibitor<br /> | **[[5ll7]] - EcBlac Kpc-2 + boronic acid inhibitor<br /> | ||
| + | **[[6mkq]], [[6mk6]] - Blac + inhibitor – ''Vibrio cholerae''<br /> | ||
*'''Other β-lactamase''' | *'''Other β-lactamase''' | ||
| Line 377: | Line 425: | ||
**[[2gdn]], [[3zhh]], [[5oyo]], [[5nj2]] – MtBlac – ''Mycobacterium tuberculosis''<br /> | **[[2gdn]], [[3zhh]], [[5oyo]], [[5nj2]] – MtBlac – ''Mycobacterium tuberculosis''<br /> | ||
**[[4whi]] – MtBlac C terminal<br /> | **[[4whi]] – MtBlac C terminal<br /> | ||
| - | **[[4jlf]] - MtBlac (mutant)<br /> | + | **[[4jlf]], [[6h28]], [[6h27]] - MtBlac (mutant)<br /> |
**[[2jc7]], [[3g4p]] – AbBlac <br /> | **[[2jc7]], [[3g4p]] – AbBlac <br /> | ||
**[[3byd]] – KoBlac <br /> | **[[3byd]] – KoBlac <br /> | ||
| Line 394: | Line 442: | ||
**[[4k0w]] – AbBlac Oxa-23 (mutant)<br /> | **[[4k0w]] – AbBlac Oxa-23 (mutant)<br /> | ||
**[[4k0x]] – AbBlac Oxa-23 <br /> | **[[4k0x]] – AbBlac Oxa-23 <br /> | ||
| + | **[[6goa]] – AbBlac Oxa-48 (mutant)<br /> | ||
| + | **[[5oft]] – KpBlac Oxa-48 (mutant)<br /> | ||
**[[5oe0]] – KpBlac Oxa-181 <br /> | **[[5oe0]] – KpBlac Oxa-181 <br /> | ||
| + | **[[5oe2]] – KpBlac Oxa-245 <br /> | ||
| + | **[[6gth]] – KpBlac <br /> | ||
**[[3wrt]] – ChBlac – ''Chromohalobacter''<br /> | **[[3wrt]] – ChBlac – ''Chromohalobacter''<br /> | ||
**[[3wrz]], [[3ws0]], [[3ws1]], [[3ws2]], [[3ws3]], [[3ws4]], [[3ws5]] – ChBlac (mutant)<br /> | **[[3wrz]], [[3ws0]], [[3ws1]], [[3ws2]], [[3ws3]], [[3ws4]], [[3ws5]] – ChBlac (mutant)<br /> | ||
| + | **[[6njk]] – Blac – ''Sulfitobacter''<br /> | ||
| + | **[[6n9k]] – EcBlac <br /> | ||
| + | **[[6n36]] – Blac – ''Chitinophaga pinensis''<br /> | ||
| + | **[[6mu9]] – Blac – ''Bacillus megaterium''<br /> | ||
| + | **[[6ch0]], [[6cgy]] – AaBlac – ''Alicyclobacillus acidoterrestris''<br /> | ||
| + | |||
*Other β-lactamase binary complex | *Other β-lactamase binary complex | ||
| Line 408: | Line 466: | ||
**[[3cg5]], [[4q8i]], [[4qb8]] – MtBlac + antibiotic<br /> | **[[3cg5]], [[4q8i]], [[4qb8]] – MtBlac + antibiotic<br /> | ||
**[[3n8s]], [[3ny4]], [[3n6i]], [[3n7w]], [[3n8l]], [[3n8r]], [[3nbl]], [[3nc8]], [[3nck]], [[3nde]], [[3ndg]] - MtBlac (mutant) + antibiotic<br /> | **[[3n8s]], [[3ny4]], [[3n6i]], [[3n7w]], [[3n8l]], [[3n8r]], [[3nbl]], [[3nc8]], [[3nck]], [[3nde]], [[3ndg]] - MtBlac (mutant) + antibiotic<br /> | ||
| - | **[[3dwz]], [[3iqa]], [[3m6b]], [[3m6h]], [[4df6]] – MtBlac + inhibitor<br /> | + | **[[3dwz]], [[3iqa]], [[3m6b]], [[3m6h]], [[4df6]], [[6h2k]], [[6h2i]], [[6h2h]], [[6h2g]], [[6h2c]] – MtBlac + inhibitor<br /> |
**[[4x6t]], [[4qhc]] – MtBlac (mutant) + inhibitor<br /> | **[[4x6t]], [[4qhc]] – MtBlac (mutant) + inhibitor<br /> | ||
**[[3vff]], [[3vfh]], [[4ebl]], [[4ebn]], [[4ebp]] – MtBlac (mutant) + intermediate<br /> | **[[3vff]], [[3vfh]], [[4ebl]], [[4ebn]], [[4ebp]] – MtBlac (mutant) + intermediate<br /> | ||
| + | **[[6h2a]] – MtBlac (mutant) + protein<br /> | ||
**[[3fv7]], [[3fyz]], [[3fzc]], [[3mbz]] – AbBlac + inhibitor<br /> | **[[3fv7]], [[3fyz]], [[3fzc]], [[3mbz]] – AbBlac + inhibitor<br /> | ||
**[[4wm9]] – AbBlac Oxa-24 + antibiotic <br /> | **[[4wm9]] – AbBlac Oxa-24 + antibiotic <br /> | ||
| + | **[[6q5b]], [[6q5f]] – KpBlac Oxa-48 (mutant) + avibactam <br /> | ||
| + | **[[6cgz]] – AaBlac + lactone derivative<br /> | ||
}} | }} | ||
Revision as of 09:28, 14 April 2019
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3D Structures of Beta-lactamase
Updated on 14-April-2019
2aio – StmBlac B + antibiotic 3q6x, 4ey2, 4eyb, 4eyf, 4efl, 4hl1, 4hl2, 4eyl, 4hky, 4ram, 4raw, 4rbs, 4rl0, 4rl2, 5of2, 5o2e – KpBlac B Ndm-1+ antibiotic
References
- ↑ King D, Strynadka N. Crystal structure of New Delhi metallo-beta-lactamase reveals molecular basis for antibiotic resistance. Protein Sci. 2011 Sep;20(9):1484-91. doi: 10.1002/pro.697. Epub 2011 Aug, 2. PMID:21774017 doi:10.1002/pro.697
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman
