Blue copper oxidase CueO

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<StructureSection load='4ner' size='340' side='right' caption='Structure of E. coli blue copper oxidase CueO complex with 4 Cu+2 ions (orange) and acetate (PDB code [[4e9s]]).' scene=''>
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<StructureSection load='2fqf' size='350' side='right' caption='Structure of E. coli blue copper oxidase CueO complex with two Cu+2 ions (orange), Cu-O-Cu and citrate (PDB code [[2fqf]]).' scene='59/593960/Cv/1'>
== Function ==
== Function ==
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'''Blue copper oxidase CueO''' (CueO) is an ''E. coli'' enzyme which catalyzes the conversion of Cu+1 to Cu+2 resulting in the detoxification of copper by the prevention of its uptake into the cytoplasm.
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'''Blue copper oxidase CueO''' (CueO) or '''laccase CueO''' is an ''E. coli'' enzyme which catalyzes the conversion of Cu+1 to Cu+2 resulting in the detoxification of copper by the prevention of its uptake into the cytoplasm.<ref>PMID:11527384</ref>
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== Disease ==
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== Relevance ==
== Relevance ==
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CueO is involved in prevention of oxidative damage in the periplasm.
== Structural highlights ==
== Structural highlights ==
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The Cu moieties (Cu-O-Cu and Cu+2) are coordinated by at least 2 histidine residues: <scene name='59/593960/Cv/7'>Cu and Cu-O-Cu</scene> and <scene name='59/593960/Cv/8'>single Cu</scene>.<ref>PMID:17217912</ref>
==3D structures of blue copper oxidase CueO==
==3D structures of blue copper oxidase CueO==
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[[Blue copper oxidase CueO 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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[[3nsf]] – EcCueO – ''Escherichia coli''<br />
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[[3nt0]] – EcCueO (mutant) + Cu+1 <br />
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[[3od3]], [[3pav]], [[4e9q]], [[4e9r]], [[4e9s]], [[4e9t]], [[4ef3]], [[4ner]] – EcCueO + Cu+2 <br />
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[[3nsc]], [[3nsd]], [[3uaa]], [[3uab]], [[3uac]], [[3uad]], [[3uae]], [[4hak]], [[4hal]] – EcCueO (mutant) + Cu+2 <br />
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[[3qqx]] – EcCueO (mutant) + Cu+2 + Cu+1<br />
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[[1n68]] – EcCueO + Cu+2 + Cu-Cl-Cu <br />
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[[1pf3]] – EcCueO (mutant) + Cu+2 + Cu-Cl-Cu <br />
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[[2fqd]], [[2fqe]], [[2fqf]], [[2fqg]], [[3pau]] – EcCueO + Cu+2 + Cu-O-Cu <br />
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[[2yxv]], [[2yxw]], [[3nsy]] – EcCueO (mutant) + Cu+2 + Cu-O-Cu <br />
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Current revision

Structure of E. coli blue copper oxidase CueO complex with two Cu+2 ions (orange), Cu-O-Cu and citrate (PDB code 2fqf).

Drag the structure with the mouse to rotate


References

  1. ↑ Grass G, Rensing C. CueO is a multi-copper oxidase that confers copper tolerance in Escherichia coli. Biochem Biophys Res Commun. 2001 Sep 7;286(5):902-8. PMID:11527384 doi:http://dx.doi.org/10.1006/bbrc.2001.5474
  2. ↑ Li X, Wei Z, Zhang M, Peng X, Yu G, Teng M, Gong W. Crystal structures of E. coli laccase CueO at different copper concentrations. Biochem Biophys Res Commun. 2007 Mar 2;354(1):21-6. Epub 2006 Dec 22. PMID:17217912 doi:10.1016/j.bbrc.2006.12.116

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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