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BRCA

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== Structural highlights ==
== Structural highlights ==
The <scene name='75/750267/Cv/5'>phosphopeptide binds at the interface between the BRCT1 and BRCT2 domains</scene>. These domains contain most of the mutations seen in BRCA1<ref>PMID:18452305</ref>. <scene name='75/750267/Cv/6'>Phosphoserine binding</scene>.
The <scene name='75/750267/Cv/5'>phosphopeptide binds at the interface between the BRCT1 and BRCT2 domains</scene>. These domains contain most of the mutations seen in BRCA1<ref>PMID:18452305</ref>. <scene name='75/750267/Cv/6'>Phosphoserine binding</scene>.
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==3D structures of BRCA==
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[[BRCA 3D structures]]
</StructureSection>
</StructureSection>

Revision as of 09:56, 16 April 2019

Human BRCA1 BRCT1 and BRCT2 domains complex with phosphopeptide (PDB code 3coj)

Drag the structure with the mouse to rotate

3D structures of BRCA

Updated on 16-April-2019

References

  1. ↑ Petrucelli N, Daly MB, Pal T. BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer PMID:20301425
  2. ↑ Shen Y, Tong L. Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1. Biochemistry. 2008 May 27;47(21):5767-73. Epub 2008 May 2. PMID:18452305 doi:10.1021/bi800314m

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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