This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6d49
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Cell Surface Receptor in Complex with Ligand at 1.80-A Resolution== | |
| - | + | <StructureSection load='6d49' size='340' side='right'caption='[[6d49]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6d49]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D49 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D49 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FVP:2-aminoethyl+5-{[(4-cyclohexyl-1H-1,2,3-triazol-1-yl)acetyl]amino}-3,5,9-trideoxy-9-[(4-hydroxy-3,5-dimethylbenzene-1-carbonyl)amino]-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2- 6)-beta-D-galactopyranosyl-(1- 4)-beta-D-glucopyranoside'>FVP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6d48|6d48]], [[6d4a|6d4a]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d49 OCA], [http://pdbe.org/6d49 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d49 RCSB], [http://www.ebi.ac.uk/pdbsum/6d49 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d49 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CD33_HUMAN CD33_HUMAN]] Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).<ref>PMID:10556798</ref> <ref>PMID:11320212</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hermans, S J]] | ||
| + | [[Category: Miles, L A]] | ||
| + | [[Category: Parker, M W]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Receptor]] | ||
| + | [[Category: Sialic acid binding]] | ||
| + | [[Category: Siglec]] | ||
| + | [[Category: Transmembrane]] | ||
Revision as of 05:53, 17 April 2019
Cell Surface Receptor in Complex with Ligand at 1.80-A Resolution
| |||||||||||
