Butyrylcholinesterase

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Like in the AChE structure, BChE active site is located at the bottom of a ca. 20A deep gorge. The <scene name='39/399020/Cv/6'>active site of BChE</scene> is similar to that of AChE. <ref>PMID:12869558</ref> Water molecule is shown as red sphere. The differences are noticed in the lining of the gorge were some of the aromatic residues in AChE are substituted by hydrophobic ones and in the active site acyl-binding pocket where 2 Phe residues are replaced by Leu and Val in BChE.
Like in the AChE structure, BChE active site is located at the bottom of a ca. 20A deep gorge. The <scene name='39/399020/Cv/6'>active site of BChE</scene> is similar to that of AChE. <ref>PMID:12869558</ref> Water molecule is shown as red sphere. The differences are noticed in the lining of the gorge were some of the aromatic residues in AChE are substituted by hydrophobic ones and in the active site acyl-binding pocket where 2 Phe residues are replaced by Leu and Val in BChE.
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</StructureSection>
 
==3D structures of BChE==
==3D structures of BChE==
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[[Butyrylcholinesterase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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* hBChE - Apo human
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**[[2pm8]], [[1p0i]] - hBChE - human <br />
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**[[2xmb]] – hBChE (mutant)+SO4<br />
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**[[2xmc]] - hBChE (mutant)+F <br />
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**[[4aqd]] - hBChE (fully glycosylated)
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* BChE+OP irreversible inhibitors, including nerve agents and insecticides
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**[[3djy]], [[3dkk]] - hBChE+tabun <br />
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**[[2wid]], [[2wif]] - hBChE+Tabun analogue TA1 <br />
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**[[2wsl]], [[2wig]] – hBChE+Tabun analogue TA4 <br />
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**[[2wil]], [[2wij]] - hBChE+Tabun analogue TA5 <br />
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**[[2wik]] - hBChE+Tabun analogue TA6 <br />
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**[[1xlw]] - hBChE+echothiophate <br />
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**[[1xmd]], [[2xmd]] – hBChE (mutant)+echothiophate<br />
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**[[1p0q]] - hBChE+soman <br />
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**[[1xlu]] - hBChE+Di-Isopropyl-Phosphoro-Fluoridate (DFP)<br />
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**[[2xmg]] - hBChE (mutant)+VX<br />
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**[[1xlv]] – hBChE+ethyl dihydrogen phosphate<br />
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**[[2y1k]], [[4bbz]] - hBChE (mutant) + CBDP <br />
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**[[4b0p]], [[4b0o]] - hBChE (Aged) + pyridinium derivative<br />
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**[[4axb]] – hBChE (aged) + 2-PAM
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* BChE+inhibitor binding at surface of the protein (far from the active site)
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**[[2j4c]] – hBChE+ HgCl2 <br />
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* BChE + substrate analogues mimicking the binding of the substrate butyrylcholine
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**[[1p0m]] - hBChE+choline <br />
 
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**[[1p0p]] - hBChE+butyrylthiocholine<br />
 
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**[[3o9m]] - hBChE + benzoic acid<br />
 
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**[[1eho]], [[1ehq]], [[1kcj]] – hBChE + cocaine - model<br />
 
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**[[4bds]] – hBChE + tacrine<br />
 
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}}
 
==Additional Resources==
==Additional Resources==
For additional information, see: [[Alzheimer's Disease]]
For additional information, see: [[Alzheimer's Disease]]

Current revision

Glycosylated human butyrylcholinesterase complex with choline, glycerol, sulfate and Cl- ions (PDB code 1p0m)

Drag the structure with the mouse to rotate

Additional Resources

For additional information, see: Alzheimer's Disease

References

  1. ↑ Darvesh S, Hopkins DA, Geula C. Neurobiology of butyrylcholinesterase. Nat Rev Neurosci. 2003 Feb;4(2):131-8. PMID:12563284 doi:http://dx.doi.org/10.1038/nrn1035
  2. ↑ Nicolet Y, Lockridge O, Masson P, Fontecilla-Camps JC, Nachon F. Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products. J Biol Chem. 2003 Oct 17;278(42):41141-7. Epub 2003 Jul 17. PMID:12869558 doi:http://dx.doi.org/10.1074/jbc.M210241200
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