Butyrylcholinesterase
From Proteopedia
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of BChE== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | * hBChE - Apo human | ||
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| - | **[[2pm8]], [[1p0i]] - hBChE - human <br /> | ||
| - | **[[2xmb]] – hBChE (mutant)+SO4<br /> | ||
| - | **[[2xmc]] - hBChE (mutant)+F <br /> | ||
| - | **[[4aqd]] - hBChE (fully glycosylated) | ||
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| - | * BChE+OP irreversible inhibitors, including nerve agents and insecticides | ||
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| - | **[[3djy]], [[3dkk]] - hBChE+tabun <br /> | ||
| - | **[[2wid]], [[2wif]] - hBChE+Tabun analogue TA1 <br /> | ||
| - | **[[2wsl]], [[2wig]] – hBChE+Tabun analogue TA4 <br /> | ||
| - | **[[2wil]], [[2wij]] - hBChE+Tabun analogue TA5 <br /> | ||
| - | **[[2wik]] - hBChE+Tabun analogue TA6 <br /> | ||
| - | **[[1xlw]] - hBChE+echothiophate <br /> | ||
| - | **[[1xmd]], [[2xmd]] – hBChE (mutant)+echothiophate<br /> | ||
| - | **[[1p0q]] - hBChE+soman <br /> | ||
| - | **[[1xlu]] - hBChE+Di-Isopropyl-Phosphoro-Fluoridate (DFP)<br /> | ||
| - | **[[2xmg]] - hBChE (mutant)+VX<br /> | ||
| - | **[[1xlv]] – hBChE+ethyl dihydrogen phosphate<br /> | ||
| - | **[[2y1k]], [[4bbz]] - hBChE (mutant) + CBDP <br /> | ||
| - | **[[4b0p]], [[4b0o]] - hBChE (Aged) + pyridinium derivative<br /> | ||
| - | **[[4axb]] – hBChE (aged) + 2-PAM | ||
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| - | * BChE+inhibitor binding at surface of the protein (far from the active site) | ||
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| - | **[[2j4c]] – hBChE+ HgCl2 <br /> | ||
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| - | * BChE + substrate analogues mimicking the binding of the substrate butyrylcholine | ||
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| - | **[[1p0m]] - hBChE+choline <br /> | ||
| - | **[[1p0p]] - hBChE+butyrylthiocholine<br /> | ||
| - | **[[3o9m]] - hBChE + benzoic acid<br /> | ||
| - | **[[1eho]], [[1ehq]], [[1kcj]] – hBChE + cocaine - model<br /> | ||
| - | **[[4bds]], [[6i0b]] – hBChE + tacrine derivative<br /> | ||
| - | }} | ||
==Additional Resources== | ==Additional Resources== | ||
For additional information, see: [[Alzheimer's Disease]] | For additional information, see: [[Alzheimer's Disease]] | ||
Current revision
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Additional Resources
For additional information, see: Alzheimer's Disease
References
- ↑ Darvesh S, Hopkins DA, Geula C. Neurobiology of butyrylcholinesterase. Nat Rev Neurosci. 2003 Feb;4(2):131-8. PMID:12563284 doi:http://dx.doi.org/10.1038/nrn1035
- ↑ Nicolet Y, Lockridge O, Masson P, Fontecilla-Camps JC, Nachon F. Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products. J Biol Chem. 2003 Oct 17;278(42):41141-7. Epub 2003 Jul 17. PMID:12869558 doi:http://dx.doi.org/10.1074/jbc.M210241200
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