This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6oe7
From Proteopedia
(Difference between revisions)
m (Protected "6oe7" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of HMCES cross-linked to DNA abasic site== | |
| - | + | <StructureSection load='6oe7' size='340' side='right'caption='[[6oe7]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6oe7]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OE7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OE7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DRZ:3,4-DIHYDROXY-PENTANAL-5-PHOSPHATE'>DRZ</scene></td></tr> |
| - | [[Category: Arrowsmith, C | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oe7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oe7 OCA], [http://pdbe.org/6oe7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oe7 RCSB], [http://www.ebi.ac.uk/pdbsum/6oe7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oe7 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HMCES_HUMAN HMCES_HUMAN]] Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (PubMed:23945014).<ref>PMID:23945014</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Halabelian, L]] | ||
[[Category: Li, Y]] | [[Category: Li, Y]] | ||
| - | [[Category: | + | [[Category: Structural genomic]] |
[[Category: Zeng, H]] | [[Category: Zeng, H]] | ||
| - | [[Category: | + | [[Category: 3' overhang]] |
| - | [[Category: | + | [[Category: Dna binding protein-dna complex]] |
| - | [[Category: | + | [[Category: Dna damage protein]] |
| + | [[Category: Dna-binding]] | ||
| + | [[Category: Hmce]] | ||
| + | [[Category: Protein-dna complex]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Srap domain]] | ||
Revision as of 07:05, 24 April 2019
Crystal structure of HMCES cross-linked to DNA abasic site
| |||||||||||
