This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5is5
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Discovery and Pharmacological Characterization of Novel Quinazoline-based PI3K delta-selective Inhibitors== | ==Discovery and Pharmacological Characterization of Novel Quinazoline-based PI3K delta-selective Inhibitors== | ||
| - | <StructureSection load='5is5' size='340' side='right' caption='[[5is5]], [[Resolution|resolution]] 2.85Å' scene=''> | + | <StructureSection load='5is5' size='340' side='right'caption='[[5is5]], [[Resolution|resolution]] 2.85Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5is5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IS5 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5is5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IS5 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6CY:5-{4-[3-(4-ACETYLPIPERAZINE-1-CARBONYL)PHENYL]QUINAZOLIN-6-YL}-2-METHOXYPYRIDINE-3-CARBONITRILE'>6CY</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6CY:5-{4-[3-(4-ACETYLPIPERAZINE-1-CARBONYL)PHENYL]QUINAZOLIN-6-YL}-2-METHOXYPYRIDINE-3-CARBONITRILE'>6CY</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Pik3cd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol-4,5-bisphosphate_3-kinase Phosphatidylinositol-4,5-bisphosphate 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.153 2.7.1.153] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol-4,5-bisphosphate_3-kinase Phosphatidylinositol-4,5-bisphosphate 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.153 2.7.1.153] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5is5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5is5 OCA], [http://pdbe.org/5is5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5is5 RCSB], [http://www.ebi.ac.uk/pdbsum/5is5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5is5 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5is5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5is5 OCA], [http://pdbe.org/5is5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5is5 RCSB], [http://www.ebi.ac.uk/pdbsum/5is5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5is5 ProSAT]</span></td></tr> | ||
| Line 21: | Line 22: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lk3 transgenic mice]] | ||
[[Category: Phosphatidylinositol-4,5-bisphosphate 3-kinase]] | [[Category: Phosphatidylinositol-4,5-bisphosphate 3-kinase]] | ||
[[Category: Gutmann, S]] | [[Category: Gutmann, S]] | ||
Revision as of 07:36, 24 April 2019
Discovery and Pharmacological Characterization of Novel Quinazoline-based PI3K delta-selective Inhibitors
| |||||||||||
