Catenin

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<StructureSection load='2z6g' size='350' side='right' scene='41/417478/Cv/3' caption='Zebrafish β-catenin (PDB code [[2z6g]])'>
<StructureSection load='2z6g' size='350' side='right' scene='41/417478/Cv/3' caption='Zebrafish β-catenin (PDB code [[2z6g]])'>
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__TOC__
 
== Function ==
== Function ==
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[[Catenin|Catenins]] (CTN) are proteins which make complexes with [[cadherin]].<br />
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[[Catenin|Catenins]] (CTN) are proteins which make complexes with [[cadherin]].<ref>PMID:17005550</ref><br />
* '''α-CTN''' links cadherin (CDH) and α-actinin, it is encoded by 3 genes: '''α-E-CTN''' (epithelial), '''α-T-CTN''' (membrane bound), and '''α-N-CTN''' (neuronal).<br />
* '''α-CTN''' links cadherin (CDH) and α-actinin, it is encoded by 3 genes: '''α-E-CTN''' (epithelial), '''α-T-CTN''' (membrane bound), and '''α-N-CTN''' (neuronal).<br />
* '''β-CTN''' is a subunit of the cadherin complex. It contains [[Armadillo repeats]] which are a pair of helices forming hairpin structure.<br />
* '''β-CTN''' is a subunit of the cadherin complex. It contains [[Armadillo repeats]] which are a pair of helices forming hairpin structure.<br />
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* '''δ-CTN''' is expressed in the brain and contains 10 armadillo repeats.<br />
* '''δ-CTN''' is expressed in the brain and contains 10 armadillo repeats.<br />
* '''p120 CTN''' is another member of the CTN family.<br />
* '''p120 CTN''' is another member of the CTN family.<br />
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<ref>PMID:17005550</ref>
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</StructureSection>
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== 3D Structures of Catenin ==
== 3D Structures of Catenin ==
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[[Catenin 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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* P120 CTN
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**[[3l6x]], [[3l6y]] – p120 CTN (mutant) +E-CDH – human<br />
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* α-CTN
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**[[4k1n]] - mα-CTN - mouse<br />
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**[[1l7c]], [[4k1o]] – mα-CTN C-terminal <br />
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**[[4igg]] - hα-CTN<br />
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**[[1h6g]] - hα-CTN M domain<br />
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**[[1dov]] - mα-CTN dimerization domain<br />
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**[[1dow]] - mα-CTN dimerization domain+ mβ-CTN chimera<br />
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**[[4ehp]] - hα-CTN residues 277-382 + vinculin head domain<br />
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* β-CTN
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**[[3diw]] – mβ-CTN C-terminal+Tax interaction protein 1 <br />
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**[[2z6g]] - β-CTN – zebrafish<br />
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**[[4ev8]], [[4ev9]], [[4eva]], [[4evp]], [[4evt]] - mβ-CTN<br />
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**[[2z6h]] - hβ-CTN C-terminal<br />
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**[[2gl7]] - hβ-CTN (mutant)+TCF-4+B-cell lymphoma protein<br />
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**[[3sl9]] - hβ-CTN +B-cell lymphoma protein 9<br />
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**[[3sla]] - hβ-CTN repeats 1-4<br />
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**[[3tx7]] - hβ-CTN + nuclear receptor LRH-1<br />
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**[[2g57]] - β-CTN fragment – NMR<br />
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**[[3bct]], [[2bct]] - mβ-CTN armadillo repeats<br />
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**[[1v18]] - mβ-CTN armadillo repeats+apc protein<br />
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**[[1t08]] - hβ-CTN armadillo repeats+apc protein+ hβ-CTN interacting protein<br />
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**[[1th1]] - hβ-CTN armadillo repeats+apc protein<br />
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**[[1qz7]] - hβ-CTN armadillo repeats+axis inhibition protein <br />
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**[[1g3j]] - hβ-CTN armadillo repeats+TCF3-CBD<br />
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**[[1p22]] - hβ-CTN +skp1+trcp1<br />
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**[[1luj]] - hβ-CTN C-terminal+ hβ-CTN interacting protein<br />
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**[[1jdh]], [[1jpw]] - hβ-CTN C-terminal+HTCF-4<br />
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**[[4djs]] - hβ-CTN armadillo repeats + peptide inhibitor<br />
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**[[1m1e]] - mβ-CTN armadillo repeats + mβ-CTN interacting protein<br />
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**[[1jpp]] - mβ-CTN armadillo repeats+apc protein<br />
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**[[1i7x]], [[1i7w]] - mβ-CTN armadillo repeats+E-CDH<br />
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**[[3ouw]], [[3oux]] - mβ-CTN+lymphoid enhancer-binding factor 1
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* α+β-CTN
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**[[4ons]] - mCTN <br />
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* γ-CTN
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**[[3ifq]] – hγ-CTN+E-CDH EC1+EC2+EC3<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Zebrafish β-catenin (PDB code 2z6g)

Drag the structure with the mouse to rotate

References

  1. ↑ Weis WI, Nelson WJ. Re-solving the cadherin-catenin-actin conundrum. J Biol Chem. 2006 Nov 24;281(47):35593-7. Epub 2006 Sep 27. PMID:17005550 doi:http://dx.doi.org/10.1074/jbc.R600027200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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