CD3

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<StructureSection load='1sy6' size='450' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'>
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<StructureSection load='1sy6' size='350' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'>
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'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM). Drugs which bind to CD3 are tested as immunorepressants.<ref>PMID:24488493</ref>
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*<scene name='55/551236/Cv/2'>Human CD3 extracellular domain with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]).<ref>PMID:15136729</ref>
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</StructureSection>
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==3D structures of CD3==
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== Function ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single Immunorecetor Tyrosine-based Activation Motif (ITAM). <ref>PMID:24488493</ref><ref>PMID:15136729</ref>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*<scene name='55/551236/Cv/2'>Human CD3 extracellular domain with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]).
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*CD3 ε chain
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== Relevance ==
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**[[1a81]] – hCD3 ITAM + Syk kinase – human <BR />
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Drugs which bind to CD3 are tested as immunorepressants.
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**[[2jxb]] – hCD3 domain SH3-1<br />
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**[[2k4f]] – mCD3 ITAM – mouse - NMR <BR />
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**[[3r08]] – mCD3 extracellular domain + antibody<BR />
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**[[2mim]] – CD3 – chicken<br />
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*CD3 εγ dimer
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==3D structures of CD3==
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[[CD3 3D structures]]
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**[[1jbj]] – hCD3 extracellular domain - NMR<BR />
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**[[1sy6]] – hCD3 extracellular domain + antibody<BR />
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</StructureSection>
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*CD3 εδ dimer
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**[[1xiw]] – hCD3 extracellular domain + antibody<BR />
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**[[1xmw]] – mCD3 extracellular domain ε/sCD3 extracellular domain δ – sheep<BR />
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*CD3 ζ chain
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**[[1ygr]], [[2oq1]] – hCD3 ITAM + CD45 protein tyrosine phosphatase <BR />
 
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**[[3ik5]], [[3ioz]] – hCD3 ITAM + NEF<BR />
 
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**[[2hac]] – hCD3 transmembrane domain - NMR<BR />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category: Topic Page]]
[[Category: Topic Page]]

Current revision

Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry 1sy6)

Drag the structure with the mouse to rotate

References

  1. ↑ Berry R, Headey SJ, Call MJ, McCluskey J, Tregaskes CA, Kaufman J, Koh R, Scanlon MJ, Call ME, Rossjohn J. Structure of the chicken CD3epsilondelta/gamma heterodimer and its assembly with the alphabetaT cell receptor. J Biol Chem. 2014 Mar 21;289(12):8240-51. doi: 10.1074/jbc.M113.544965. Epub 2014, Jan 31. PMID:24488493 doi:http://dx.doi.org/10.1074/jbc.M113.544965
  2. ↑ Kjer-Nielsen L, Dunstone MA, Kostenko L, Ely LK, Beddoe T, Mifsud NA, Purcell AW, Brooks AG, McCluskey J, Rossjohn J. Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7675-80. Epub 2004 May 10. PMID:15136729 doi:10.1073/pnas.0402295101

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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