CD3
From Proteopedia
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| - | <StructureSection load='1sy6' size=' | + | <StructureSection load='1sy6' size='350' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'> |
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== Function == | == Function == | ||
| - | '''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single Immunorecetor Tyrosine-based Activation Motif (ITAM). <ref>PMID:24488493</ref> | + | '''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single Immunorecetor Tyrosine-based Activation Motif (ITAM). <ref>PMID:24488493</ref><ref>PMID:15136729</ref> |
*<scene name='55/551236/Cv/2'>Human CD3 extracellular domain with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]). | *<scene name='55/551236/Cv/2'>Human CD3 extracellular domain with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]). | ||
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Drugs which bind to CD3 are tested as immunorepressants. | Drugs which bind to CD3 are tested as immunorepressants. | ||
| - | <ref>PMID:15136729</ref> | ||
| - | </StructureSection> | ||
==3D structures of CD3== | ==3D structures of CD3== | ||
| + | [[CD3 3D structures]] | ||
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| + | </StructureSection> | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *CD3 ε chain | ||
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| - | **[[1a81]] – hCD3 ITAM + Syk kinase – human <BR /> | ||
| - | **[[2jxb]] – hCD3 domain SH3-1<br /> | ||
| - | **[[2k4f]] – mCD3 ITAM – mouse - NMR <BR /> | ||
| - | **[[3r08]] – mCD3 extracellular domain + antibody<BR /> | ||
| - | **[[2mim]] – CD3 – chicken<br /> | ||
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| - | *CD3 εγ dimer | ||
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| - | **[[1jbj]] – hCD3 extracellular domain - NMR<BR /> | ||
| - | **[[1sy6]] – hCD3 extracellular domain + antibody<BR /> | ||
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| - | *CD3 εδ dimer | ||
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| - | **[[1xiw]] – hCD3 extracellular domain + antibody<BR /> | ||
| - | **[[1xmw]] – mCD3 extracellular domain ε/sCD3 extracellular domain δ – sheep<BR /> | ||
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| - | *CD3 ζ chain | ||
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| - | **[[1ygr]], [[2oq1]] – hCD3 ITAM + CD45 protein tyrosine phosphatase <BR /> | ||
| - | **[[3ik5]], [[3ioz]] – hCD3 ITAM + NEF<BR /> | ||
| - | **[[2hac]] – hCD3 transmembrane domain - NMR<BR /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Current revision
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References
- ↑ Berry R, Headey SJ, Call MJ, McCluskey J, Tregaskes CA, Kaufman J, Koh R, Scanlon MJ, Call ME, Rossjohn J. Structure of the chicken CD3epsilondelta/gamma heterodimer and its assembly with the alphabetaT cell receptor. J Biol Chem. 2014 Mar 21;289(12):8240-51. doi: 10.1074/jbc.M113.544965. Epub 2014, Jan 31. PMID:24488493 doi:http://dx.doi.org/10.1074/jbc.M113.544965
- ↑ Kjer-Nielsen L, Dunstone MA, Kostenko L, Ely LK, Beddoe T, Mifsud NA, Purcell AW, Brooks AG, McCluskey J, Rossjohn J. Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7675-80. Epub 2004 May 10. PMID:15136729 doi:10.1073/pnas.0402295101
