1fd0

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[[Image:1fd0.gif|left|200px]]
[[Image:1fd0.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1fd0 |SIZE=350|CAPTION= <scene name='initialview01'>1fd0</scene>, resolution 1.38&Aring;
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The line below this paragraph, containing "STRUCTURE_1fd0", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=254:6-[HYDROXYIMINO-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALEN-2-YL)-METHYL]-NAPHTALENE-2-CARBOXYLIC+ACID'>254</scene>, <scene name='pdbligand=LMU:DODECYL-ALPHA-D-MALTOSIDE'>LMU</scene>
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{{STRUCTURE_1fd0| PDB=1fd0 | SCENE= }}
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|RELATEDENTRY=[[2lbd|2LBD]], [[3lbd|3LBD]], [[1exa|1EXA]], [[1exx|1EXX]], [[1fcz|1fcz]], [[1fcy|1fcy]], [[1fcx|1fcx]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fd0 OCA], [http://www.ebi.ac.uk/pdbsum/1fd0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fd0 RCSB]</span>
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}}
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'''ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE RARGAMMA-SELECTIVE RETINOID SR11254'''
'''ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE RARGAMMA-SELECTIVE RETINOID SR11254'''
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[[Category: Moras, D.]]
[[Category: Moras, D.]]
[[Category: SPINE, Structural Proteomics in Europe.]]
[[Category: SPINE, Structural Proteomics in Europe.]]
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[[Category: antiparallel alpha-helical sandwich fold]]
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[[Category: Antiparallel alpha-helical sandwich fold]]
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[[Category: ch...o hydrogen bond]]
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[[Category: Ch...o hydrogen bond]]
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[[Category: drug design]]
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[[Category: Drug design]]
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[[Category: isotype selectivity]]
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[[Category: Isotype selectivity]]
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[[Category: retinoid ligand complex]]
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[[Category: Retinoid ligand complex]]
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[[Category: spine]]
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[[Category: Spine]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural proteomics in europe]]
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[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:06:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:20:29 2008''
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Revision as of 05:06, 13 April 2008

Image:1fd0.gif

Template:STRUCTURE 1fd0

ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE RARGAMMA-SELECTIVE RETINOID SR11254


Overview

Hydrogen bonds between polarized atoms play a crucial role in protein interactions and are often used in drug design, which usually neglects the potential of C-H...O hydrogen bonds. The 1.4 A resolution crystal structure of the ligand binding domain of the retinoic acid receptor RARgamma complexed with the retinoid SR11254 reveals several types of C-H...O hydrogen bonds. A striking example is the hydroxyl group of the ligand that acts as an H bond donor and acceptor, leading to a synergy between classical and C-H...O hydrogen bonds. This interaction introduces both specificity and affinity within the hydrophobic ligand pocket. The similarity of intraprotein and protein-ligand C-H...O interactions suggests that such bonds should be considered in rational drug design approaches.

About this Structure

1FD0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

C-H...O hydrogen bonds in the nuclear receptor RARgamma--a potential tool for drug selectivity., Klaholz B, Moras D, Structure. 2002 Sep;10(9):1197-204. PMID:12220491 Page seeded by OCA on Sun Apr 13 08:06:32 2008

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OCA

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