C-di-GMP specific phosphodiesterases
From Proteopedia
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<StructureSection load='2w27' size='350' side='right' scene='' caption='C-di-GMP specific phosphodiesterase complex with guanosine-5-monophosphate (stick model) and Ca+2 ions (green) (PDB code [[2w27]])'> | <StructureSection load='2w27' size='350' side='right' scene='' caption='C-di-GMP specific phosphodiesterase complex with guanosine-5-monophosphate (stick model) and Ca+2 ions (green) (PDB code [[2w27]])'> | ||
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== YkuI == | == YkuI == | ||
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<scene name='User:Tilman_Schirmer/Sandbox_202/Blrp1_active_site_ligand_hoh/2'>Active site + ligand + Mn + HOH</scene> | <scene name='User:Tilman_Schirmer/Sandbox_202/Blrp1_active_site_ligand_hoh/2'>Active site + ligand + Mn + HOH</scene> | ||
| - | [[C-di-GMP signaling|See also | + | == Additional Resources == |
| + | [[C-di-GMP signaling|See also C-di-GMP signaling]] | ||
</StructureSection> | </StructureSection> | ||
==3D structure of C-di-GMP phosphodiesterase== | ==3D structure of C-di-GMP phosphodiesterase== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *YkuI | ||
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| - | **[[2bas]] – BsYkuI – ''Bacillus subtilis''<br /> | ||
| - | **[[2w27]] – BsYkuI + C-di-GMP | ||
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| - | *BlrP1 | ||
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| - | **[[3gfx]], [[3gfy]], [[3gfz]], [[3gg0]], [[3gg1]] – KpBlrP1 + C-di-GMP - ''Klebsiella pneumoniae''<br /> | ||
| - | **[[2kb2]] - KpBlrP1 BLUF domain - NMR | ||
| - | }} | ||
| - | ==3D structures of phosphodiesterase== | ||
[[Phosphodiesterase]] | [[Phosphodiesterase]] | ||
Current revision
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3D structure of C-di-GMP phosphodiesterase
References
YkuI structure 2w27:
- Minasov G, Padavattan S, Shuvalova L, Brunzelle JS, Miller DJ, Basle A, Massa C, Collart FR, Schirmer T, Anderson WF. Crystal structures of YkuI and its complex with second messenger cyclic Di-GMP suggest catalytic mechanism of phosphodiester bond cleavage by EAL domains. J Biol Chem. 2009 May 8;284(19):13174-84. Epub 2009 Feb 24. PMID:19244251 doi:10.1074/jbc.M808221200
BlrP1 structure 3gg0:
- Barends TR, Hartmann E, Griese JJ, Beitlich T, Kirienko NV, Ryjenkov DA, Reinstein J, Shoeman RL, Gomelsky M, Schlichting I. Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase. Nature. 2009 Jun 18;459(7249):1015-8. PMID:19536266 doi:10.1038/nature07966
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Joel L. Sussman, Alexander Berchansky, Tilman Schirmer
