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5ajs

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Revision as of 12:57, 10 May 2019

Crystal structure of a coiled-coil domain from human THAP11

Structural highlights

5ajs is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[THA11_HUMAN] Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).

Publication Abstract from PubMed

Thanatos associated protein 11 (THAP11) is a cell cycle and cell growth regulator differentially expressed in cancer cells. THAP11 belongs to a distinct family of transcription factors recognizing specific DNA sequences via an atypical zinc finger motif and regulating diverse cellular processes. Outside the extensively characterized DNA-binding domain, THAP proteins vary in size and predicted domains, for which structural data are still lacking. We report here the crystal structure of the C-terminal region of human THAP11 protein, providing the first 3D structure of a coiled-coil motif from a THAP family member. We further investigate the stability, dynamics and oligomeric properties of the determined structure combining molecular dynamics simulations and biophysical experiments. Our results show that the C-ter region of THAP11 forms a left-handed parallel homo-dimeric coiled-coil structure possessing several unusual features.

The C-terminal region of the transcriptional regulator THAP11 forms a parallel coiled-coil domain involved in protein dimerization.,Cukier CD, Maveyraud L, Saurel O, Guillet V, Milon A, Gervais V J Struct Biol. 2016 Jun;194(3):337-46. doi: 10.1016/j.jsb.2016.03.010. Epub 2016 , Mar 11. PMID:26975212^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Cukier CD, Maveyraud L, Saurel O, Guillet V, Milon A, Gervais V. The C-terminal region of the transcriptional regulator THAP11 forms a parallel coiled-coil domain involved in protein dimerization. J Struct Biol. 2016 Jun;194(3):337-46. doi: 10.1016/j.jsb.2016.03.010. Epub 2016 , Mar 11. PMID:26975212 doi:http://dx.doi.org/10.1016/j.jsb.2016.03.010

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5ajs"

@@ Line 1: / Line 1: @@
 ==Crystal structure of a coiled-coil domain from human THAP11==
-<StructureSection load='5ajs' size='340' side='right' caption='[[5ajs]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+<StructureSection load='5ajs' size='340' side='right'caption='[[5ajs]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5ajs]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AJS FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5ajs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AJS FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ajs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ajs OCA], [http://pdbe.org/5ajs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ajs RCSB], [http://www.ebi.ac.uk/pdbsum/5ajs PDBsum]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ajs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ajs OCA], [http://pdbe.org/5ajs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ajs RCSB], [http://www.ebi.ac.uk/pdbsum/5ajs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ajs ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 21: / Line 21: @@
 __TOC__
 </StructureSection>
+[[Category: Human]]
+[[Category: Large Structures]]
 [[Category: Cukier, C D]]
 [[Category: Gervais, V]]

5ajs

From Proteopedia

Revision as of 12:57, 10 May 2019

Crystal structure of a coiled-coil domain from human THAP11

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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