Choline kinase

(Difference between revisions)

Current revision

Structure of human choline kinase α2 complex with phosphocholine (PDB code 2ckq).

Drag the structure with the mouse to rotate

↑ Malito E, Sekulic N, Too WC, Konrad M, Lavie A. Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine. J Mol Biol. 2006 Nov 24;364(2):136-51. Epub 2006 Sep 3. PMID:17007874 doi:10.1016/j.jmb.2006.08.084

@@ Line 1: / Line 1: @@
-<StructureSection load='2ckp' size='340' side='right' caption='Structure of human choline kinase α2 complex with phosphocholine (PDB code [[2ckp]]). ' scene=''>
+<StructureSection load='2ckq' size='340' side='right' caption='Structure of human choline kinase α2 complex with phosphocholine (PDB code [[2ckq]]). ' scene='59/593958/Cv/1'>
 == Function ==
@@ Line 12: / Line 12: @@
 == Structural highlights ==
-</StructureSection>
+The choline binds to CK in a <scene name='59/593958/Cv/5'>deep hydrophobic groove</scene> (PDB code [[2ckq]]; {{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar}}) and the <scene name='59/593958/Cv/6'>ADP binds in a cleft</scene> (PDB code [[2ckp]]). <ref>PMID:17007874</ref>
 ==3D structures of choline kinase==
+[[Choline kinase 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Choline kinase
-**[[2i7q]] – hCK α – human<br />
-**[[2cko]] – hCK α2 <br />
-*Choline kinase complexes
-**[[2ckp]] – hCK α2 + ADP<br />
-**[[2ckq]] – hCK α2 + phosphocholine<br />
-**[[3zm9]], [[4da5]], [[4br3]] – hCK α + inhibitor<br />
-**[[3f2r]] – hCK α + hemicholinium-3<br />
-**[[3g15]] – hCK α + hemicholinium-3 + ADP<br />
-**[[4cg8]], [[4cg9]], [[4cga]] – hCK α1 + bispyridinium derivative<br />
-}}
 == References ==