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Complement C5
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='3pvm' size='340' side='right' caption='Human complement C5 complex with cobra venom factor (PDB code 3pvm)' scene=''> '''Complement C5''' (CC5) is the fifth co...) |
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| + | <StructureSection load='' size='350' side='right' caption='Human complement C5 complex (green) with cobra venom factor (magenta) (PDB code [[3pvm]])' scene='70/705685/Cv/6'> | ||
| + | __TOC__ | ||
| + | == Function == | ||
| - | + | '''Complement C5''' (CC5) is the fifth component of the complement system. The complement system is part of the innate immune system. CC5 is composed of α chain (C5a) and β chain (C5b). Proteoplytic degradation of CC5 produces <scene name='70/705685/Cv/4'>anaphylatoxin</scene> which is a mediator of local inflammatory process. The C terminal domain of CC5 (residues 1530-1676) is homologous to a domain in netrins and is named <scene name='70/705685/Cv/5'>C345C</scene>. Activation of CC5 by C5 convertase initiates the assembly of the C5 to C9 components into the membrane attack complex. <ref>PMID:18536718</ref> | |
| - | '''Complement C5''' (CC5) is the fifth component of the complement system. The complement system is part of the innate immune system. CC5 is composed of α chain (C5a) and β chain (C5b). Proteoplytic degradation of CC5 produces '' | + | |
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== Disease == | == Disease == | ||
| - | Mutations in CC5 cause a deficiency leading to severe recurrent infections and are linked to liver fibrosis and rheumatoid arthritis. | + | Mutations in CC5 cause a deficiency leading to severe recurrent infections and are linked to liver fibrosis, Leiner's disease and rheumatoid arthritis. |
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| + | == 3D Structures of complement C5 == | ||
| + | [[Complement C5 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of complement C5 == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *CC5 | ||
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| - | **[[3cu7]] – hCC5 – human <BR /> | ||
| - | **[[3kls]], [[3km9]] – hCC5 + exotoxin 1 <BR /> | ||
| - | **[[3pvm]] – hCC5 + cobra venom factor <BR /> | ||
| - | **[[3prx]] – hCC5 + cobra venom factor + SSL7<BR /> | ||
| - | **[[4a5w]], [[4e0s]] – hCC5 + CC6<BR /> | ||
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| - | *C345C | ||
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| - | **[[1xwe]] – hCC5 (mutant) - NMR <BR /> | ||
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| - | *C5a anaphylatoxin | ||
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| - | **[[1kjs]], [[3hqa]], [[3hqb]] – hCC5 <BR /> | ||
| - | **[[4p3a]], [[4p3b]] – mCC5 - mouse <BR /> | ||
| - | **[[4wb3]], [[4wb2]] – mCC5 + DNA/RNA <BR /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
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References
- ↑ Fredslund F, Laursen NS, Roversi P, Jenner L, Oliveira CL, Pedersen JS, Nunn MA, Lea SM, Discipio R, Sottrup-Jensen L, Andersen GR. Structure of and influence of a tick complement inhibitor on human complement component 5. Nat Immunol. 2008 Jul;9(7):753-60. Epub 2008 Jun 8. PMID:18536718 doi:10.1038/ni.1625
