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Hepatocyte growth factor activator
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' caption='Human hepatocyte growth factor activator (magenta) complex with HGFA inhibitor type 1 (green) and phosphate (PDB code [[1yc0]])' scene='70/706236/Cv/1'> |
== Function == | == Function == | ||
'''Hepatocyte growth factor activator''' (HGFA) is a serine protease which links tissue injury to activation of hepatocyte growth factor (HGF). HGFA converts HGF from its latent single-chain form to a heterodimeric active form. HGFA is synthesized as an inactive precursor which is converted to a heterodimer via proteolysis as a result of tissue injury<ref>PMID:20402766</ref>. | '''Hepatocyte growth factor activator''' (HGFA) is a serine protease which links tissue injury to activation of hepatocyte growth factor (HGF). HGFA converts HGF from its latent single-chain form to a heterodimeric active form. HGFA is synthesized as an inactive precursor which is converted to a heterodimer via proteolysis as a result of tissue injury<ref>PMID:20402766</ref>. | ||
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| - | == Disease == | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | + | HGFA substrate binding cleft resembles other trypsin-like serine proteases with <scene name='70/706236/Cv/4'>inhibitors of the Kunitz type (α/β folds rich in Cys-Cys bonds)</scene> <ref>PMID:157134585</ref>. | |
</StructureSection> | </StructureSection> | ||
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== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
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3D Structures of hepatocyte growth factor activator
Updated on 15-May-2019
1ybw – hHGFA protease domain – human
1yc0 – hHGFA protease domain + Kunitz-type protease inhibitor
2r0l, 2r0k, 2wub, 2wuc, 3k2u – hHGFA protease domain + antibody
References
- ↑ Miyazawa K. Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor. FEBS J. 2010 May;277(10):2208-14. doi: 10.1111/j.1742-4658.2010.07637.x. Epub, 2010 Apr 2. PMID:20402766 doi:http://dx.doi.org/10.1111/j.1742-4658.2010.07637.x
- ↑ Wu KL, Li YQ, Tabassum A, Lu WY, Aubert I, Wong CS. Loss of neuronal protein expression in mouse hippocampus after irradiation. J Neuropathol Exp Neurol. 2010 Mar;69(3):272-80. doi:, 10.1097/NEN.0b013e3181d1afe4. PMID:20142763 doi:http://dx.doi.org/10.1097/NEN.0b013e3181d1afe4
- ↑ . PMID:157134585
