This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Laccase
From Proteopedia
(Difference between revisions)
| Line 2: | Line 2: | ||
== Function == | == Function == | ||
| - | '''CotA laccase''' | + | '''Laccase''' (Lac) is a multi-copper protein which uses molecular oxygen to oxidize various aromatic and non-aromatic compounds by a radical-catalyzed reaction mechanism</ref><ref>PMID:15036303</ref> |
| + | '''CotA laccase''' belongs to the multi-copper oxidase family. | ||
The multi-copper oxidases constitute a family of enzymes whose | The multi-copper oxidases constitute a family of enzymes whose | ||
principal members are laccase (benzenediol oxygen oxidoreductase, | principal members are laccase (benzenediol oxygen oxidoreductase, | ||
| Line 14: | Line 15: | ||
== Structural highlights == | == Structural highlights == | ||
| - | The trinuclear center has two type 3 copper ions, that can be anti-ferromagnetically | + | The trinuclear center of CotA laccase has two type 3 copper ions, that can be anti-ferromagnetically |
coupled through an hydroxyl moiety in between them, and one | coupled through an hydroxyl moiety in between them, and one | ||
type 2 copper ion.‡ The mononuclear copper is able to accept an | type 2 copper ion.‡ The mononuclear copper is able to accept an | ||
Revision as of 09:29, 16 May 2019
| |||||||||||
3D structures of CotA laccase
Updated on 16-May-2019
References
- ↑ Claus H. Laccases: structure, reactions, distribution. Micron. 2004;35(1-2):93-6. doi: 10.1016/j.micron.2003.10.029. PMID:15036303 doi:http://dx.doi.org/10.1016/j.micron.2003.10.029
- ↑ Hullo MF, Moszer I, Danchin A, Martin-Verstraete I. CotA of Bacillus subtilis is a copper-dependent laccase. J Bacteriol. 2001 Sep;183(18):5426-30. PMID:11514528
- ↑ Bento I, Martins LO, Gato Lopes G, Armenia Carrondo M, Lindley PF. Dioxygen reduction by multi-copper oxidases; a structural perspective. Dalton Trans. 2005 Nov 7;(21):3507-13. Epub 2005 Sep 27. PMID:16234932 doi:10.1039/b504806k
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Isabel Bento, Alexander Berchansky, David Canner, Jaime Prilusky
