This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


6gr8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "6gr8" [edit=sysop:move=sysop])
Current revision (07:25, 21 May 2019) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6gr8 is ON HOLD
+
==Human AURKC INCENP complex bound to BRD-7880==
-
 
+
<StructureSection load='6gr8' size='340' side='right'caption='[[6gr8]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
-
Authors: Abdul Azeez, K.R., Sorrell, F.J., von Delft, F., Bountra, C., Knapp, S., Edwards, A.M., Arrowsmith, C., Elkins, J.M.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6gr8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GR8 FirstGlance]. <br>
-
Description: Human AURKC INCENP complex bound to BRD-7880
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F8Z:1-[(2~{R},3~{S})-2-[[1,3-benzodioxol-5-ylmethyl(methyl)amino]methyl]-3-methyl-6-oxidanylidene-5-[(2~{S})-1-oxidanylpropan-2-yl]-3,4-dihydro-2~{H}-1,5-benzoxazocin-8-yl]-3-(4-methoxyphenyl)urea'>F8Z</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-
[[Category: Elkins, J.M]]
+
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AURKC, AIE2, AIK3, AIRK3, ARK3, STK13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), INCENP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
 +
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gr8 OCA], [http://pdbe.org/6gr8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gr8 RCSB], [http://www.ebi.ac.uk/pdbsum/6gr8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gr8 ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[[http://www.uniprot.org/uniprot/AURKC_HUMAN AURKC_HUMAN]] Male infertility due to large-headed multiflagellar polyploid spermatozoa. The disease is caused by mutations affecting the gene represented in this entry.
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/AURKC_HUMAN AURKC_HUMAN]] Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.<ref>PMID:15316025</ref> <ref>PMID:15499654</ref> <ref>PMID:15670791</ref> <ref>PMID:15938719</ref> <ref>PMID:21493633</ref> <ref>PMID:21531210</ref> <ref>PMID:27332895</ref> [[http://www.uniprot.org/uniprot/INCE_HUMAN INCE_HUMAN]] Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1.<ref>PMID:15316025</ref> <ref>PMID:12925766</ref> <ref>PMID:16760428</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Human]]
 +
[[Category: Large Structures]]
 +
[[Category: Non-specific serine/threonine protein kinase]]
 +
[[Category: Arrowsmith, C]]
 +
[[Category: Azeez, K R.Abdul]]
 +
[[Category: Bountra, C]]
 +
[[Category: Delft, F von]]
 +
[[Category: Edwards, A M]]
 +
[[Category: Elkins, J M]]
[[Category: Knapp, S]]
[[Category: Knapp, S]]
-
[[Category: Edwards, A.M]]
+
[[Category: Sorrell, F J]]
-
[[Category: Abdul Azeez, K.R]]
+
[[Category: Kinase]]
-
[[Category: Von Delft, F]]
+
[[Category: Sgc]]
-
[[Category: Bountra, C]]
+
[[Category: Structural genomic]]
-
[[Category: Arrowsmith, C]]
+
[[Category: Transferase]]
-
[[Category: Sorrell, F.J]]
+

Current revision

Human AURKC INCENP complex bound to BRD-7880

PDB ID 6gr8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6gr8"
Personal tools