This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6h24
From Proteopedia
(Difference between revisions)
m (Protected "6h24" [edit=sysop:move=sysop]) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==X-Ray Crystal Structure of the MSBI1.176 WH1 Domain, a Replication Protein Isolated from a Multiple Sclerosis Patient== | |
| + | <StructureSection load='6h24' size='340' side='right'caption='[[6h24]], [[Resolution|resolution]] 1.53Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6h24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sphinx1.76-related_dna Sphinx1.76-related dna]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H24 FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rep ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1515702 Sphinx1.76-related DNA])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h24 OCA], [http://pdbe.org/6h24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h24 RCSB], [http://www.ebi.ac.uk/pdbsum/6h24 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h24 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Bovine meat and milk factors (BMMFs) are circular, single-stranded episomal DNAs that have been detected in bovine meat and milk products. BMMFs are thought to have roles in human malignant and degenerative diseases. BMMFs encode a replication initiator protein (Rep) that is actively transcribed and translated in human cells. In this study, a Rep WH1 domain encoded on a BMMF (MSBI1.176) isolated from a multiple sclerosis human brain sample was determined to 1.53 A resolution using X-ray crystallography. The overall structure of the MSBI1.176 WH1 domain was remarkably similar to other Rep structures, despite having a low (28%) amino-acid sequence identity. The MSBI1.176 WH1 domain contained elements common to other Reps, including five alpha-helices, five beta-strands and a hydrophobic pocket. These new findings suggest that the MSBI1.176 Rep might have comparable roles and functions to other known Reps of different origins. | ||
| - | + | Structural analysis of a replication protein encoded by a plasmid isolated from a multiple sclerosis patient.,Kilic T, Popov AN, Burk-Korner A, Koromyslova A, Zur Hausen H, Bund T, Hansman GS Acta Crystallogr D Struct Biol. 2019 May 1;75(Pt 5):498-504. doi:, 10.1107/S2059798319003991. Epub 2019 Apr 29. PMID:31063152<ref>PMID:31063152</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6h24" style="background-color:#fffaf0;"></div> |
| - | [[Category: Hansman, G | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Sphinx1 76-related dna]] | ||
| + | [[Category: Hansman, G S]] | ||
[[Category: Kilic, T]] | [[Category: Kilic, T]] | ||
| + | [[Category: Popov, A N]] | ||
| + | [[Category: Msbi1 176]] | ||
| + | [[Category: Repa]] | ||
| + | [[Category: Replication]] | ||
| + | [[Category: Sclerosis]] | ||
| + | [[Category: Wh1]] | ||
Current revision
X-Ray Crystal Structure of the MSBI1.176 WH1 Domain, a Replication Protein Isolated from a Multiple Sclerosis Patient
| |||||||||||
Categories: Large Structures | Sphinx1 76-related dna | Hansman, G S | Kilic, T | Popov, A N | Msbi1 176 | Repa | Replication | Sclerosis | Wh1
