Cyclohydrolase
From Proteopedia
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</StructureSection> | </StructureSection> | ||
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| - | ==3D structures of cyclohydrolase== | ||
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| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *GTP cyclohydrolase I | ||
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| - | **[[1gtp]] – EcGCH I – ''Escherichia coli''<br /> | ||
| - | **[[5k9g]] – NgGCH IB + Zn – ''Neisseria gonorrhoeae''<br /> | ||
| - | **[[3d2o]] – NgGCH IB + Mn<br /> | ||
| - | **[[1fb1]] – hGCH I + Zn – human<br /> | ||
| - | **[[1wm9]] – TtGCH I + Zn – ''Thermus thermophilus''<br /> | ||
| - | **[[4uqf]] – GCH I – ''Listeria monocytogenes'' <br /> | ||
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| - | *''GTP cyclohydrolase I complexes'' | ||
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| - | **[[1a8r]], [[1a9c]], [[1n3r]], [[1n3t]], [[1n3s]] – EcGCH I (mutant) + GTP <br /> | ||
| - | **[[4du6]] – GCH I + GTP – ''Yersinia pseudotuberculosis''<br /> | ||
| - | **[[1fbx]] – EcGCH I + Zn <br /> | ||
| - | **[[1wuq]], [[1wur]] – TtGCH I + Zn + 8-oxo-GTP <br /> | ||
| - | **[[5k95]] – NgGCH 1B + Zn + 8-oxo-GTP <br /> | ||
| - | **[[1is7]] – rGCH I + GCH feedback regulatory protein - rat<br /> | ||
| - | **[[1is8]] – rGCH I + GCH feedback regulatory protein + Zn<br /> | ||
| - | **[[1wpl]] – rGCH I + GCH feedback regulatory protein + Zn + dihydrobiopterin<br /> | ||
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| - | *GTP cyclohydrolase II | ||
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| - | **[[2bz1]] – EcGCH II + Zn <br /> | ||
| - | **[[2bz0]] – EcGCH II + Zn + phosphomethylphosphonic acid guanylate<br /> | ||
| - | **[[4rl4]] – GCH II – ''Helicobacter pylori'' <br /> | ||
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| - | *GTP cyclohydrolase III | ||
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| - | **[[2qv6]] – GCH III + GTP + Ca – ''Methanocaldococcus jannaschii'' <br /> | ||
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| - | *IMP cyclohydrolase | ||
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| - | **[[2ntm]] – MtICH – ''Methanothermobacter thermoautotrophicus''<br /> | ||
| - | **[[2ntk]] – MtICH + IMP <br /> | ||
| - | **[[2ntl]] – MtICH + AICAR<br /> | ||
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| - | *Methenyltetrahydromethanopterin cyclohydrolase | ||
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| - | **[[1qlm]] – MCH – ''Methanopyrus kandleri''<br /> | ||
| - | **[[4fio]] – MCH – ''Methanobrevibacter ruminatium''<br /> | ||
| - | **[[4gvr]] – AfMCH – ''Archaeoglobus fulgidus''<br /> | ||
| - | **[[4gvq]] – AfMCH + tetrahydromethanopterin <br /> | ||
| - | **[[4gvs]] – AfMCH + N5-formyl-tetrahydromethanopterin <br /> | ||
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| - | * Methylenetetrahydrofolate dehydrogenase/cyclohydrolase | ||
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| - | **[[2c2x]], [[2c2y]] – MCH – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[1a4i]], [[6ecr]] – hMCH + NADP <br /> | ||
| - | **[[1dig]], [[1dia]], [[1dib]],[[6ecp]], [[6ecq]], [[5tc4]] – hMCH + NADP + inhibitor<br /> | ||
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| - | *Phosphoribosyl-ATP cyclohydrolase | ||
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| - | **[[1zps]] – MtPCH + Cd <br /> | ||
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== References == | == References == | ||
Revision as of 09:04, 22 May 2019
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References
- ↑ Nar H, Huber R, Meining W, Schmid C, Weinkauf S, Bacher A. Atomic structure of GTP cyclohydrolase I. Structure. 1995 May 15;3(5):459-66. PMID:7663943
- ↑ Ren J, Kotaka M, Lockyer M, Lamb HK, Hawkins AR, Stammers DK. GTP cyclohydrolase II structure and mechanism. J Biol Chem. 2005 Nov 4;280(44):36912-9. Epub 2005 Aug 22. PMID:16115872 doi:10.1074/jbc.M507725200
- ↑ Kang YN, Tran A, White RH, Ealick SE. A novel function for the N-terminal nucleophile hydrolase fold demonstrated by the structure of an archaeal inosine monophosphate cyclohydrolase. Biochemistry. 2007 May 1;46(17):5050-62. Epub 2007 Apr 4. PMID:17407260 doi:http://dx.doi.org/10.1021/bi061637j
- ↑ Upadhyay V, Demmer U, Warkentin E, Moll J, Shima S, Ermler U. Structure and catalytic mechanism of N(5),N(10)-methenyl-tetrahydromethanopterin cyclohydrolase. Biochemistry. 2012 Oct 23;51(42):8435-43. doi: 10.1021/bi300777k. Epub 2012 Oct, 8. PMID:23013430 doi:http://dx.doi.org/10.1021/bi300777k
- ↑ Schmidt A, Wu H, MacKenzie RE, Chen VJ, Bewly JR, Ray JE, Toth JE, Cygler M. Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. Biochemistry. 2000 May 30;39(21):6325-35. PMID:10828945
- ↑ Rebelo J, Auerbach G, Bader G, Bracher A, Nar H, Hosl C, Schramek N, Kaiser J, Bacher A, Huber R, Fischer M. Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I. J Mol Biol. 2003 Feb 14;326(2):503-16. PMID:12559918
