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4xco

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Revision as of 07:14, 29 May 2019

Signal-sequence induced conformational changes in the signal recognition particle

Structural highlights

4xco is a 6 chain structure with sequence from [1] and Atcc 43067. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	3ndb
Gene:	srp19, MJ1034 (ATCC 43067), mj0101, srp54 (ATCC 43067)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SRP54_METJA] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.[HAMAP-Rule:MF_00306] [SRP19_METJA] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP (By similarity).

Publication Abstract from PubMed

Co-translational protein targeting is an essential, evolutionarily conserved pathway for delivering nascent proteins to the proper cellular membrane. In this pathway, the signal recognition particle (SRP) first recognizes the N-terminal signal sequence of nascent proteins and subsequently interacts with the SRP receptor. For this, signal sequence binding in the SRP54 M domain must be effectively communicated to the SRP54 NG domain that interacts with the receptor. Here we present the 2.9 A crystal structure of unbound- and signal sequence bound SRP forms, both present in the asymmetric unit. The structures provide evidence for a coupled binding and folding mechanism in which signal sequence binding induces the concerted folding of the GM linker helix, the finger loop, and the C-terminal alpha helix alphaM6. This mechanism allows for a high degree of structural adaptability of the binding site and suggests how signal sequence binding in the M domain is coupled to repositioning of the NG domain.

Signal-sequence induced conformational changes in the signal recognition particle.,Hainzl T, Sauer-Eriksson AE Nat Commun. 2015 Jun 8;6:7163. doi: 10.1038/ncomms8163. PMID:26051119^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Hainzl T, Sauer-Eriksson AE. Signal-sequence induced conformational changes in the signal recognition particle. Nat Commun. 2015 Jun 8;6:7163. doi: 10.1038/ncomms8163. PMID:26051119 doi:http://dx.doi.org/10.1038/ncomms8163

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4xco"

@@ Line 1: / Line 1: @@
 ==Signal-sequence induced conformational changes in the signal recognition particle==
-<StructureSection load='4xco' size='340' side='right' caption='[[4xco]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
+<StructureSection load='4xco' size='340' side='right'caption='[[4xco]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4xco]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XCO FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4xco]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Atcc_43067 Atcc 43067]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XCO FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ndb|3ndb]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">srp19, MJ1034 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 ATCC 43067]), mj0101, srp54 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 ATCC 43067])</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xco OCA], [http://pdbe.org/4xco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xco RCSB], [http://www.ebi.ac.uk/pdbsum/4xco PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xco ProSAT]</span></td></tr>
 </table>
@@ Line 26: / Line 27: @@
 __TOC__
 </StructureSection>
+[[Category: Atcc 43067]]
+[[Category: Large Structures]]
 [[Category: Hainzl, T]]
 [[Category: Sauer-Eriksson, A E]]

4xco

From Proteopedia

Revision as of 07:14, 29 May 2019

Signal-sequence induced conformational changes in the signal recognition particle

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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