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4x60
From Proteopedia
(Difference between revisions)
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==Crystal structure of PRMT5:MEP50 with EPZ015666 and sinefungin== | ==Crystal structure of PRMT5:MEP50 with EPZ015666 and sinefungin== | ||
| - | <StructureSection load='4x60' size='340' side='right' caption='[[4x60]], [[Resolution|resolution]] 2.35Å' scene=''> | + | <StructureSection load='4x60' size='340' side='right'caption='[[4x60]], [[Resolution|resolution]] 2.35Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4x60]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X60 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4x60]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X60 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3XV:N-[(2S)-3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YL)-2-HYDROXYPROPYL]-6-(OXETAN-3-YLAMINO)PYRIMIDINE-4-CARBOXAMIDE'>3XV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3XV:N-[(2S)-3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YL)-2-HYDROXYPROPYL]-6-(OXETAN-3-YLAMINO)PYRIMIDINE-4-CARBOXAMIDE'>3XV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x61|4x61]], [[4x63|4x63]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x61|4x61]], [[4x63|4x63]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRMT5, HRMT1L5, IBP72, JBP1, SKB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), WDR77, MEP50, WD45, HKMT1069, Nbla10071 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x60 OCA], [http://pdbe.org/4x60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x60 RCSB], [http://www.ebi.ac.uk/pdbsum/4x60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x60 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x60 OCA], [http://pdbe.org/4x60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x60 RCSB], [http://www.ebi.ac.uk/pdbsum/4x60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x60 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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</div> | </div> | ||
<div class="pdbe-citations 4x60" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4x60" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Histone methyltransferase|Histone methyltransferase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Boriack-Sjodin, P A]] | [[Category: Boriack-Sjodin, P A]] | ||
[[Category: Protein arginine methyltransferase]] | [[Category: Protein arginine methyltransferase]] | ||
[[Category: Protein-inhibitor complex]] | [[Category: Protein-inhibitor complex]] | ||
[[Category: Transferase-transferase inhibitor complex]] | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 07:19, 29 May 2019
Crystal structure of PRMT5:MEP50 with EPZ015666 and sinefungin
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