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Insulin receptor

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== Structural highlights ==
== Structural highlights ==
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<scene name='51/516456/Cv/2'>Human insulin receptor tyrosine kinase catalytic domain complex with insulin receptor substrate 2 peptide, Mg+2 ion and ATP</scene> (PDB entry [[3bu5]]).
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<scene name='51/516456/Cv/8'>Human insulin receptor tyrosine kinase catalytic domain complex with insulin receptor substrate 2 peptide, Mg+2 ion and ATP</scene> (PDB entry [[3bu5]]).
TK domain of IR contains an activation loop and a catalytic loop and <scene name='51/516456/Cv/7'>3 phosphorylated tyrosine residues</scene>. The bound IR substrate 2 peptide tyrosine is the phosphorylated residue<ref>PMID:18278056</ref>.
TK domain of IR contains an activation loop and a catalytic loop and <scene name='51/516456/Cv/7'>3 phosphorylated tyrosine residues</scene>. The bound IR substrate 2 peptide tyrosine is the phosphorylated residue<ref>PMID:18278056</ref>.
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<scene name='51/516456/Cv/6'>ATP/Mg binding site</scene>. Water molecules shown as red spheres.
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<scene name='51/516456/Cv/9'>ATP/Mg binding site</scene>. Water molecules shown as red spheres.
See also [[Insulin Receptor - kinase domain (hebrew)]] and [[Insulin receptor (Hebrew)]].
See also [[Insulin Receptor - kinase domain (hebrew)]] and [[Insulin receptor (Hebrew)]].

Revision as of 13:01, 29 May 2019

Structure of human insulin receptor tyrosine kinase catalytic domain complex with insulin receptor substrate 2 peptide (cyan), Mg+2 ion (green) and ATP (PDB entry 3bu5)

Drag the structure with the mouse to rotate

3D structures of insulin receptor

1irk – hIR TK domain – human
1i44, 1p14 – hIR TK domain (mutant)
2hr7 – hIR domains 1-3
4xst – hIR  L1-CR domains
2mfr – hIR transmembrane domain - NMR
5j3h – hIR  L1-CR domains + antibody + peptide
4xss – hIR  L1-CR domains + insulin-like growth factor 1
4xlv - hIR TK domain (mutant) + ATP derivative
1ir3 - hIR TK domain (mutant) + ATP analog + peptide
3bu5, 3bu6 - hIR TK domain + ATP + peptide
3bu3 - hIR TK domain + peptide
1gag, 2z8c - hIR TK domain (mutant) + peptide
3ekk, 3ekn, 4ibm, 5hhw - hIR TK domain (mutant) + inhibitor
3eta, 5e1s - hIR TK domain + inhibitor
4zxb - hIR ectodomain (mutant) + antibody
2auh – hIR TK domain + growth factor receptor-bound protein 14
2b4s - hIR TK domain + tyrosine-protein phosphatase
1rqq – hIR TK domain (mutant) + adaptor protein PS
6ce7, 6ce9, 6ceb – hIR + insulin
5kqv – hIR + insulin + antibody

References

  1. ↑ Lee J, Pilch PF. The insulin receptor: structure, function, and signaling. Am J Physiol. 1994 Feb;266(2 Pt 1):C319-34. PMID:8141246
  2. ↑ Frasca F, Pandini G, Sciacca L, Pezzino V, Squatrito S, Belfiore A, Vigneri R. The role of insulin receptors and IGF-I receptors in cancer and other diseases. Arch Physiol Biochem. 2008 Feb;114(1):23-37. doi: 10.1080/13813450801969715 . PMID:18465356 doi:http://dx.doi.org/10.1080/13813450801969715
  3. ↑ Wu J, Tseng YD, Xu CF, Neubert TA, White MF, Hubbard SR. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nat Struct Mol Biol. 2008 Mar;15(3):251-8. Epub 2008 Feb 17. PMID:18278056 doi:10.1038/nsmb.1388
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