Death-associated protein kinase
From Proteopedia
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DAPK1 structure contains a small β sheet N-terminal lobe and a larger helix-rich C-terminal lobe. <scene name='51/517372/Cv/3'>The ATP substrate is bound in a cleft between the two lobes</scene>. <ref>PMID:11573098</ref> | DAPK1 structure contains a small β sheet N-terminal lobe and a larger helix-rich C-terminal lobe. <scene name='51/517372/Cv/3'>The ATP substrate is bound in a cleft between the two lobes</scene>. <ref>PMID:11573098</ref> | ||
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| + | ==3D structures of death-associated protein kinase== | ||
| + | [[Death-associated protein kinase 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
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**[[4pf4]] - hDAPK catalytic domain + Mg<br /> | **[[4pf4]] - hDAPK catalytic domain + Mg<br /> | ||
**[[1wmk]], [[2a27]], [[3dgk]], [[4uv0]] - hDAPK catalytic domain (mutant) <br /> | **[[1wmk]], [[2a27]], [[3dgk]], [[4uv0]] - hDAPK catalytic domain (mutant) <br /> | ||
| - | **[[2xuu]], [[4b4l]], [[4tl0]] - hDAPK catalytic and autoregulatory domains (mutant) <br /> | + | **[[2xuu]], [[4b4l]], [[4tl0]], [[6fha]], [[6fhb]] - hDAPK catalytic and autoregulatory domains (mutant) <br /> |
**[[1p4f]], [[1wvw]], [[1wvx]], [[1wvy]], [[2yak]], [[4txc]] – hDAPK catalytic domain + inhibitor<br /> | **[[1p4f]], [[1wvw]], [[1wvx]], [[1wvy]], [[2yak]], [[4txc]] – hDAPK catalytic domain + inhibitor<br /> | ||
**[[4yo4]] – hDAPK catalytic domain + phthalazine<br /> | **[[4yo4]] – hDAPK catalytic domain + phthalazine<br /> | ||
**[[4ypd]] – hDAPK catalytic domain + pyridazine<br /> | **[[4ypd]] – hDAPK catalytic domain + pyridazine<br /> | ||
| + | **[[5vja]] – hDAPK catalytic domain + pyridine derivative<br /> | ||
**[[5aut]], [[5auu]], [[5auv]], [[5auw]], [[5aux]], [[5auy]], [[5auz]], [[5av0]], [[5av1]], [[5av2]], [[5av3]], [[5av4]] – hDAPK catalytic domain + flavonoid<br /> | **[[5aut]], [[5auu]], [[5auv]], [[5auw]], [[5aux]], [[5auy]], [[5auz]], [[5av0]], [[5av1]], [[5av2]], [[5av3]], [[5av4]] – hDAPK catalytic domain + flavonoid<br /> | ||
**[[2x0g]] - hDAPK catalytic domain + calmodulin | **[[2x0g]] - hDAPK catalytic domain + calmodulin | ||
Revision as of 09:34, 4 June 2019
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3D structures of death-associated protein kinase
Updated on 04-June-2019
References
- ↑ Bialik S, Kimchi A. The death-associated protein kinases: structure, function, and beyond. Annu Rev Biochem. 2006;75:189-210. PMID:16756490 doi:http://dx.doi.org/10.1146/annurev.biochem.75.103004.142615
- ↑ Tereshko V, Teplova M, Brunzelle J, Watterson DM, Egli M. Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression. Nat Struct Biol. 2001 Oct;8(10):899-907. PMID:11573098 doi:10.1038/nsb1001-899
